Zobrazeno 1 - 10
of 109
pro vyhledávání: '"syngeneic model"'
Autor:
Marie-Océane Laguillaumie, Sofia Titah, Aurélie Guillemette, Bernadette Neve, Frederic Leprêtre, Pascaline Ségard, Faruk Azam Shaik, Dominique Collard, Jean-Claude Gerbedoen, Léa Fléchon, Lama Hasan Bou Issa, Audrey Vincent, Martin Figeac, Shéhérazade Sebda, Céline Villenet, Jérôme Kluza, William Laine, Isabelle Fournier, Jean-Pascal Gimeno, Maxence Wisztorski, Salomon Manier, Mehmet Cagatay Tarhan, Bruno Quesnel, Thierry Idziorek, Yasmine Touil
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-28 (2024)
Abstract Background Tumour dormancy, a resistance mechanism employed by cancer cells, is a significant challenge in cancer treatment, contributing to minimal residual disease (MRD) and potential relapse. Despite its clinical importance, the mechanism
Externí odkaz:
https://doaj.org/article/a30941614df749d1805f6f87c1b51f5b
Akademický článek
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Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background Immune checkpoint blockade (ICB) therapies have changed the paradigm of cancer therapies. However, anti-tumor response of the ICB is insufficient for many patients and limited to specific tumor types. Despite many preclinical and
Externí odkaz:
https://doaj.org/article/3465f26f991b40ce939b170193878dc3
Autor:
Wenyan Zhong, Jeremy S. Myers, Fang Wang, Kai Wang, Justin Lucas, Edward Rosfjord, Judy Lucas, Andrea T. Hooper, Sharon Yang, Lu Anna Lemon, Magali Guffroy, Chad May, Jadwiga R. Bienkowska, Paul A. Rejto
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-17 (2020)
Abstract Background The clinical success of immune checkpoint inhibitors demonstrates that reactivation of the human immune system delivers durable responses for some patients and represents an exciting approach for cancer treatment. An important cla
Externí odkaz:
https://doaj.org/article/8611614a41274bc88abf31f1a71b7264
Autor:
Avijit Goswami, Barnali Deb, Sandeep Goyal, Abhishek Gosavi, Mukund Mali, Ashwita M. Martis, Princy Khurana, Mukesh Gangar, Digambar Raykar, Ankita Mohanty, Aditya Kulkarni
Publikováno v:
Molecules, Vol 27, Iss 19, p 6721 (2022)
Cyclic GMP-AMP synthase (cGAS) is an endogenous DNA sensor that synthesizes cyclic guanosine monophosphate–adenosine monophosphate (2′3′-cGAMP) from ATP and GTP. 2′3′-cGAMP activates the stimulator of interferon genes (STING) pathway, resul
Externí odkaz:
https://doaj.org/article/f597e29de0c943f99dc61d9a681ec00a
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background Mouse clinical trials (MCTs) are becoming wildly used in pre-clinical oncology drug development, but a statistical framework is yet to be developed. In this study, we establish such as framework and provide general guidelines on t
Externí odkaz:
https://doaj.org/article/af1a7da929654af88e9d356770b2de55
Organotypic tumor slice cultures provide a versatile platform for immuno-oncology and drug discovery
Autor:
Ramya Sivakumar, Marina Chan, Jiye Stella Shin, Nao Nishida-Aoki, Heidi L. Kenerson, Olivier Elemento, Himisha Beltran, Raymond Yeung, Taranjit S. Gujral
Publikováno v:
OncoImmunology, Vol 8, Iss 12 (2019)
Organotypic tumor slices represent a physiologically-relevant culture system for studying the tumor microenvironment. Systematic characterization of the tumor slice culture system will enable its effective application for translational research. Here
Externí odkaz:
https://doaj.org/article/9c72ba7fdcd04e50aee7360dda5c3acf
Autor:
Michael Chamo, Omri Koren, Oron Goldstein, Nir Bujanover, Nurit Keinan, Ye’ela Scharff, Roi Gazit
Publikováno v:
Cancers
Volume 15
Issue 3
Pages: 720
Volume 15
Issue 3
Pages: 720
Acute Myeloid Leukemia (AML) is a severe disease with a very high relapse rate. AML relapse may be attributable to leukemic stem cells (LSC). Notably, the “cancer stem cell” theory, which relates to LSCs, is controversial and criticized due to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb36399e8c35b3d11ecdb495c3c4445
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Dianna Liu, Robert M. Hoffman, Jianfeng Wang, Tian Zhou, Zhiying Zhang, Xiangnan Zhou, Hua Duan, Kaiwen Hu, Haoyue Pang, Ximing Lin, Manqiang Sun
Publikováno v:
In Vivo
In vivo (Athens, Greece), vol 35, iss 4
In vivo (Athens, Greece), vol 35, iss 4
Background/aim Xihuang Wan (XHW), a traditional Chinese medicine (TCM), has been used in China for a variety of cancers including lung cancer. The present study evaluated the efficacy of XHW on a Lewis lung mouse model and explored the potential mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f3b372b1df61d2291522fbbd0147d0
https://doi.org/10.21873/invivo.12469
https://doi.org/10.21873/invivo.12469