Výsledky vyhledávání - "synaptic vesicle protein 2"

Akademický článek

Efficacy and safety of adjunctive padsevonil in adults with drug‐resistant focal epilepsy: Results from two double‐blind, randomized, placebo‐controlled trials

Autor: Michael Rademacher, Manuel Toledo, Wim Van Paesschen, Kore K. Liow, Ivan G. Milanov, Maria‐Luise Esch, Nan Wang, Merran MacPherson, William J. Byrnes, Timothy D. C. Minh, Elizabeth Webster, Konrad J. Werhahn

Publikováno v: Epilepsia Open, Vol 7, Iss 4, Pp 758-770 (2022)

Abstract Objective To characterize efficacy, safety/tolerability, and pharmacokinetics of padsevonil (PSL) administered concomitantly with ≤3 antiseizure medications (ASMs) for observable focal seizures in adults with drug‐resistant epilepsy in t

Externí odkaz: https://doaj.org/article/f7b64484d7ee4361b1b24f205981fd0f

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Efficacy and safety of adjunctive padsevonil in adults with drug-resistant focal epilepsy: Results from two double-blind, randomized, placebo-controlled trials

Autor: Michael, Rademacher, Manuel, Toledo, Wim, Van Paesschen, Kore K, Liow, Ivan G, Milanov, Maria-Luise, Esch, Nan, Wang, Merran, MacPherson, William J, Byrnes, Timothy D C, Minh, Elizabeth, Webster, Konrad J, Werhahn

Publikováno v: Scientia

Antiepileptic drug; Antiseizure medication; Tolerability Fármaco antiepiléptico; Medicamento anticonvulsivo; Tolerabilidad Medicament antiepilèptic; Medicament anticonvulsiu; Tolerabilitat Objective To characterize efficacy, safety/tolerability, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb9dc6cb4102652b5522c8f70f0a494
https://hdl.handle.net/11351/8798

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Characterization of a highly neutralizing single monoclonal antibody to botulinum neurotoxin type A

Autor: Christine Rasetti-Escargueil, Anne Wijkhuisen, Emmanuel Lemichez, Stéphanie Simon, Michel R. Popoff, Sébastien Brier, Maud Marechal

Publikováno v: FASEB Journal
FASEB Journal, 2021, 35 (5), ⟨10.1096/fj.202002492R⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2021, 35 (5), ⟨10.1096/fj.202002492R⟩

International audience; Compared to conventional antisera strategies, monoclonal antibodies (mAbs) represent an alternative and safer way to treat botulism, a fatal flaccid paralysis due to botulinum neurotoxins (BoNTs). In addition, mAbs offer the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa47619ad51c6b2afa7f5b8e8b27e30
https://pubmed.ncbi.nlm.nih.gov/33817838

Zobrazit plný text záznamu

Determining Ligand- and Lipid- Interactions of SLC Transporters

Autor: Chatzikyriakidou, Yurie

Solute carrier transporters (SLCs) mediate the inter- and intra- cellular trafficking of a plethora of substrates and are essential to cell homeostasis. Despite their importance to human physiology and their potential as therapeutic targets, many SLC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bd30b3c8866c73068d222f5b2275f046
http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-197472

Zobrazit plný text záznamu

Distribution and morphology of sensory and autonomic fibres in the subendocardial plexus of the rat heart

Autor: James F. X. Jones, Susan Pyner, Fiona C. Shenton, Thomas Campbell

Publikováno v: Journal of Anatomy
Journal of anatomy, 2020, Vol.238(1), pp.36-52 [Peer Reviewed Journal]

Cardiac reflexes originating from sensory receptors in the heart ensure blood supply to vital tissues and organs in the face of constantly changing demands. Atrial volume receptors are mechanically sensitive vagal afferents which relay to the medulla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df040c1be861846a5d380ee83571190
https://pubmed.ncbi.nlm.nih.gov/32783212

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice

Autor: Kosala N. Dissanayake, Nicolas W. Martinez, Felipe A. Court, Douglas J. Lamont, Alannah J. Mole, Richard R. Ribchester, Lyndsay M. Murray, Rachel A. Kline, Thomas M. Wishart, Maria del carmen Llavero hurtado, Alexander Ahl

Publikováno v: Kline, R, Dissanayake, K, Llavero hurtado, M D C, Martínez, N W, Ahl, A, Mole, A J, Lamont, D J, Court, F A, Ribchester, R, Wishart, T & Murray, L 2019, ' Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice. ', Neurobiology of disease, vol. 130, 104496 . https://doi.org/10.1016/j.nbd.2019.104496
Neurobiology of Disease
Neurobiology of Disease, Vol 130, Iss, Pp 104496-(2019)

Neurodegenerative and neuromuscular disorders can manifest throughout the lifespan of an individual, from infant to elderly individuals. Axonal and synaptic degeneration are early and critical elements of nearly all human neurodegenerative diseases a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6698d39a711f14f5626dba5e52213e5a
https://www.pure.ed.ac.uk/ws/files/102228857/1_s2.0_S0969996119301512_main.pdf

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání