Zobrazeno 1 - 10
of 25
pro vyhledávání: '"syöpäsolut"'
Autor:
Anna S. Kichkailo, Andrey A. Narodov, Maria A. Komarova, Tatiana N. Zamay, Galina S. Zamay, Olga S. Kolovskaya, Evgeniy E. Erakhtin, Yury E. Glazyrin, Dmitry V. Veprintsev, Roman V. Moryachkov, Vladimir V. Zabluda, Irina Shchugoreva, Polina Artyushenko, Vladimir A. Mironov, Dmitry I. Morozov, Vladimir A. Khorzhevskii, Anton V. Gorbushin, Anastasia A. Koshmanova, Elena D. Nikolaeva, Igor P. Grinev, Ivan I. Voronkovskii, Daniil S. Grek, Kirill V. Belugin, Alexander A. Volzhentsev, Oleg N. Badmaev, Natalia A. Luzan, Kirill A. Lukyanenko, Georgy Peters, Ivan N. Lapin, Andrey K. Kirichenko, Petr V. Konarev, Evgeny V. Morozov, Gleb G. Mironov, Ana Gargaun, Darija Muharemagic, Sergey S. Zamay, Elena V. Kochkina, Maya A. Dymova, Tatiana E. Smolyarova, Alexey E. Sokolov, Andrey A. Modestov, Nikolay A. Tokarev, Nikolay V. Shepelevich, Anastasia V. Ozerskaya, Natalia G. Chanchikova, Alexey V. Krat, Ruslan A. Zukov, Varvara I. Bakhtina, Pavel G. Shnyakin, Pavel A. Shesternya, Valery A. Svetlichnyi, Marina M. Petrova, Ivan P. Artyukhov, Felix N. Tomilin, Maxim V. Berezovski
Publikováno v:
Mol Ther Nucleic Acids
Here, we present DNA aptamers capable of specific binding to glial tumor cells in vitro, ex vivo, and in vivo for visualization diagnostics of central nervous system tumors. We selected the aptamers binding specifically to the postoperative human gli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f52de131555245ff4c65f6cb261370b
https://doi.org/10.1016/j.omtn.2023.03.015
https://doi.org/10.1016/j.omtn.2023.03.015
Autor:
Sara Hamis, Panu Somervuo, J. Arvid Ågren, Dagim Shiferaw Tadele, Juha Kesseli, Jacob G. Scott, Matti Nykter, Philip Gerlee, Dmitri Finkelshtein, Otso Ovaskainen
Theoretical and applied cancer studies that use individual-based models (IBMs) have been limited by the lack of a mathematical formulation that enables rigorous analysis of these models. However, spatial cumulant models (SCMs), which have arisen from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c251dc2accf610ff1d9c1a0d1f2f98a
http://hdl.handle.net/10138/357583
http://hdl.handle.net/10138/357583
Autor:
Khouloud Hchicha, Elena Cambiotti, Hmed Ben-Nasr, Daniel Chappard, Matti Haukka, Loredana Latterini, Salem Elkahoui, Arif J. Siddiqui, Mejdi Snoussi, Mohd Adnan, Houcine Naïli, Riadh Badraoui
A sulfate-bridged complex [Cu(µ2-SO4)(Im)4] (1) was prepared and structurally characterized, where Im: imidazole. The X-ray structure analysis reveals that 1 crystallizes in the monoclinic system with space group C2/c. The octahedral coordination ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412367baf25bb825bfe2b02c22734650
http://urn.fi/URN:NBN:fi:jyu-202306073564
http://urn.fi/URN:NBN:fi:jyu-202306073564
Autor:
Jouni Härkönen, Petri Pölönen, Ashik Jawahar Deen, Ilakya Selvarajan, Hanna-Riikka Teppo, Elitsa Y. Dimova, Thomas Kietzmann, Maarit Ahtiainen, Juha P. Väyrynen, Sara A. Väyrynen, Hanna Elomaa, Niko Tynkkynen, Tiia Eklund, Teijo Kuopio, Eva-Maria Talvitie, Pekka Taimen, Markku Kallajoki, Minna U. Kaikkonen, Merja Heinäniemi, Anna-Liisa Levonen
The NRF2 pathway is frequently activated in various cancer types, yet a comprehensive analysis of its effects across different malignancies is currently lacking. We developed a NRF2 activity metric and utilized it to conduct a pan-cancer analysis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9605b6d64564fd65840f4550fc55c79
http://urn.fi/URN:NBN:fi:jyu-202303132132
http://urn.fi/URN:NBN:fi:jyu-202303132132
Autor:
E. D. Sitsanidis, P. M. Kasapidou, J. R. Hiscock, V. Gubala, H. Castel, P. I. A. Popoola, A. J. Hall, A. A. Edwards
Herein, we introduce the first diphenylalanine dipeptide hydrogelator capped with the cinnamoyl functional group (Cin-L-F-L-F). We evaluate the effects of the cinnamoyl moiety on molecular self-assembly events and resultant physical properties of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a7c09e3b432d418a5546d30944621bd
https://kar.kent.ac.uk/96699/19/Sitsanidis_Probing.pdf
https://kar.kent.ac.uk/96699/19/Sitsanidis_Probing.pdf
Publikováno v:
Oncology. 96(3):115-124
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=CSC_________::bfda4ea0016c324d3647e45cb10f6c26
https://doi.org/10.1159/000495615
https://doi.org/10.1159/000495615
Autor:
Ulf-Håkan Stenman, Jouni Jokela, Hannu Koistinen, Kaarina Sivonen, Antti Poso, Matti Wahlsten, Perttu Permi, David P. Fewer, Tomas Strandin, Danillo O. Alvarenga, Matthias Nees, Mikko Metsä-Ketelä, Muhammad N. Ahmed
Publikováno v:
ACS Chemical Biology
Ahmed, M N, Wahlsten, M, Jokela, J, Nees, M, Stenman, U-H, Alvarenga, D O, Strandin, T, Sivonen, K, Poso, A, Permi, P, Metsä-Ketelä, M, Koistinen, H & Fewer, D P 2021, ' Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products ', ACS chemical biology, vol. 16, no. 11, pp. 2537–2546 . https://doi.org/10.1021/acschembio.1c00611
Ahmed, M N, Wahlsten, M, Jokela, J, Nees, M, Stenman, U-H, Alvarenga, D O, Strandin, T, Sivonen, K, Poso, A, Permi, P, Metsä-Ketelä, M, Koistinen, H & Fewer, D P 2021, ' Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products ', ACS chemical biology, vol. 16, no. 11, pp. 2537–2546 . https://doi.org/10.1021/acschembio.1c00611
Funding Information: We would like to thank A. Löfhjelm and L. Saari for excellent technical assistance. This work was supported by a Sigrid Jusélius Foundation grant to H.K. and the Academy of Finland funding (321809) to T.S. We would also like to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dab7b1e75d58c8c8668582248387f2
http://urn.fi/URN:NBN:fi:jyu-202110205299
http://urn.fi/URN:NBN:fi:jyu-202110205299
Autor:
Ilmo Kellokumpu, Kyösti Tahkola, Jan Böhm, Joni Laakkonen, Johanna Laukkarinen, Maarit Ahtiainen, Marko Salmi, Sirpa Jalkanen, Istvan Kenessey, Jukka-Pekka Mecklin
Publikováno v:
Virchows Archiv
Immune suppressing molecule CD73 is overexpressed in various cancers and associated with poor survival. Little is so far known about the predictive value of CD73 in pancreatic ductal adenocarcinoma (PDAC). The purpose of this study was to investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d8ecb737b71b2fe9a4b5a97bf6a91c
http://urn.fi/URN:NBN:fi:jyu-202007215367
http://urn.fi/URN:NBN:fi:jyu-202007215367
Publikováno v:
'Frontiers in Molecular Biosciences ', vol: 8, pages: 650881-1-650881-16 (2021)
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 8 (2021)
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 8 (2021)
Protein phosphatase 2A (PP2A) activity is critical for maintaining normal physiological cellular functions. PP2A is inhibited by endogenous inhibitor proteins in several pathological conditions including cancer. A PP2A inhibitor protein, ARPP-19, has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba8dfb1fddba38b363a21c285015fb8
http://urn.fi/URN:NBN:fi:jyu-202103312249
http://urn.fi/URN:NBN:fi:jyu-202103312249
Autor:
Morozov, Dmitry, Mironov, Vladimir, Moryachkov, Roman V., Shchugoreva, Irina A., Artyushenko, Polina V., Zamay, Galina S., Kolovskaya, Olga S., Zamay, Tatiana N., Krat, Alexey V., Molodenskiy, Dmitry S., Zabluda, Vladimir N., Veprintsev, Dmitry V., Sokolov, Alexey E., Zukov, Ruslan A., Berezovski, Maxim V., Tomilin, Felix N., Fedorov, Dmitri G., Alexeev, Yuri, Kichkailo, Anna S.
Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as synthetic analogs of antibodies and bind to a target molecule with high specificity. Aptamer affinity entirely depends on its tertiary structure and charge dist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1222::24e4a157a845400b3f1fbd68fa786c2f
http://urn.fi/URN:NBN:fi:jyu-202108234622
http://urn.fi/URN:NBN:fi:jyu-202108234622