Zobrazeno 1 - 10
of 11 507
pro vyhledávání: '"surrogate endpoint"'
Publikováno v:
World Journal of Surgical Oncology, Vol 22, Iss 1, Pp 1-9 (2024)
Abstract Purpose To address this evidence gap and validate short-term OS at less than 5 years as a reliable surrogate endpoint for 5-year OS. Methods We analyzed data from the Surveillance, Epidemiology, and End Results (SEER) database, focusing on n
Externí odkaz:
https://doaj.org/article/753424c8270c4c51a564db371170a8f5
Autor:
Meletios Dimopoulos, Pieter Sonneveld, Salomon Manier, Annette Lam, Tito Roccia, Jordan M. Schecter, Patricia Cost, Lida Pacaud, Abbey Poirier, Gabriel Tremblay, Tommy Lan, Satish Valluri, Shaji Kumar
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-7 (2024)
Abstract Objectives The goal of the research was to assess the quantitative relationship between median progression-free survival (PFS) and median overall survival (OS) specifically among patients with relapsed/refractory multiple myeloma (RRMM) base
Externí odkaz:
https://doaj.org/article/0585a86fa1414c2e9c7c39d6be67cf00
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background The increasing number of sequential treatments complicates the evaluation of overall survival (OS) in clinical trials for hepatocellular carcinoma (HCC), therefore, reliable surrogate endpoints (SEs) are required. This study aimed
Externí odkaz:
https://doaj.org/article/e1d0eed4f42e4c6e931e926eaeca2ec9
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-17 (2024)
Abstract Background Surrogate endpoints, such as those of interest in chronic kidney disease (CKD), are often evaluated using Bayesian meta-regression. Trials used for the analysis can evaluate a variety of interventions for different sub-classificat
Externí odkaz:
https://doaj.org/article/2415e4fba1da44b68fc33af09146b0c3
Publikováno v:
Frontiers in Transplantation, Vol 3 (2024)
Significant progress has been made in kidney transplantation, with 1-year graft survival nearing 95%. However, long-term allograft survival remains suboptimal, with a 10-year overall graft survival rate of only 53.6% for deceased donor transplant rec
Externí odkaz:
https://doaj.org/article/690f9a90c6d44ab1be8d55e38a5672ae
Autor:
Mei Li, Jun Liao, Li Wang, Tianye Lv, Qianfu Sun, Yan Xu, Zhi Guo, Manman Quan, Hao Qin, Haoyang Yu, Kai Zhang, Wenge Xing, Haipeng Yu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectivesThis study aimed to examine the effectiveness of the best response rate (BRR) as a surrogate for overall survival (OS), using the modified Response Evaluation Criteria in Solid Tumors (mRECIST), in patients with unresectable hepatocellular
Externí odkaz:
https://doaj.org/article/0d9ff47e67a24fb38535d0441e2b1558
Autor:
Hiroyuki Arai, Madoka Takeuchi, Wataru Ichikawa, Kohei Shitara, Yu Sunakawa, Koji Oba, Wasaburo Koizumi, Yuh Sakata, Hiroshi Furukawa, Yasuhide Yamada, Masahiro Takeuchi, Masashi Fujii
Publikováno v:
Cancer Medicine, Vol 13, Iss 1, Pp n/a-n/a (2024)
Abstract Background Individual‐level surrogates are important for management in patients treated for advanced gastric cancer (AGC). This study aimed to comprehensively investigate the correlation of multiple clinical endpoints in the first‐line c
Externí odkaz:
https://doaj.org/article/5d737d0a98a74cc1afd8f1494ebe7875
Autor:
Camilo J. Acosta, Francesco Nordio, David A. Boltz, Whitney R. Baldwin, Greg Hather, Eloi Kpamegan
Publikováno v:
Microorganisms, Vol 12, Iss 6, p 1177 (2024)
A traditional phase 3 clinical efficacy study for a Zika vaccine may be unfeasible because of the current low transmission of Zika virus (ZIKV). An alternative clinical development approach to evaluate Zika vaccine efficacy (VE) is therefore required
Externí odkaz:
https://doaj.org/article/9bdd98c738f1404ab622ff8754bcf668
Publikováno v:
EClinicalMedicine, Vol 63, Iss , Pp 102156- (2023)
Summary: Background: Cancer immunotherapy shows unique efficacy kinetics that differs from conventional treatment. These characteristics may lead to the prolongation of trial duration, hence reliable surrogate endpoints are urgently needed. We aimed
Externí odkaz:
https://doaj.org/article/a076fc76e3124444a59f2645f1b26964
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