Zobrazeno 1 - 10
of 1 186
pro vyhledávání: '"supercomplexes"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Several human diseases, including cancer and neurodegeneration, are associated with excessive mitochondrial fragmentation. In this context, mitochondrial division inhibitor (Mdivi-1) has been tested as a therapeutic to block the fission-rela
Externí odkaz:
https://doaj.org/article/13b8eb4c4627437394a757350780e95c
Autor:
Rosalba Senese, Giuseppe Petito, Elena Silvestri, Maria Ventriglia, Nicola Mosca, Nicoletta Potenza, Aniello Russo, Sara Falvo, Francesco Manfrevola, Gilda Cobellis, Teresa Chioccarelli, Veronica Porreca, Vincenza Grazia Mele, Rosanna Chianese, Pieter de Lange, Giulia Ricci, Federica Cioffi, Antonia Lanni
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
IntroductionThe contribution of Cannabinoid type 1 receptor (CB1) in mitochondrial energy transduction mechanisms and mitochondrial activities awaits deeper investigations. Our study aims to assess the impact of CB1 absence on the mitochondrial compa
Externí odkaz:
https://doaj.org/article/6dbd6e5a7fe34a61938b8419aae3a7ab
Autor:
Michele Brischigliaro, Alfredo Cabrera-Orefice, Susanne Arnold, Carlo Viscomi, Massimo Zeviani, Erika Fernández-Vizarra
Publikováno v:
eLife, Vol 12 (2023)
Mammalian mitochondrial respiratory chain (MRC) complexes are able to associate into quaternary structures named supercomplexes (SCs), which normally coexist with non-bound individual complexes. The functional significance of SCs has not been fully c
Externí odkaz:
https://doaj.org/article/5426fccc54ee4aefa85cec6a073532b0
Autor:
Nath Sunil
Publikováno v:
Biomolecular Concepts, Vol 13, Iss 1, Pp 272-288 (2022)
Following structural determination by recent advances in electron cryomicroscopy, it is now well established that the respiratory Complexes I–IV in oxidative phosphorylation (OXPHOS) are organized into supercomplexes in the respirasome. Nonetheless
Externí odkaz:
https://doaj.org/article/e09c9650e24447a2a79640ece3186f70
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106199- (2023)
Mitochondrial reactive oxygen species (mROS) have been generally considered harmful byproducts wanted to clear when elevated to avoid brain damage. However, the abundance of mROS in astrocytes is very high -about one order of magnitude above that in
Externí odkaz:
https://doaj.org/article/7979a4cd33634a7493036d1f1d216732
Akademický článek
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Autor:
Tereza Rákosníková, Silvie Kelifová, Hana Štufková, Kateřina Lokvencová, Petra Lišková, Bohdan Kousal, Tomáš Honzík, Hana Hansíková, Václav Martínek, Markéta Tesařová
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Leber hereditary optic neuropathy is a primary mitochondrial disease characterized by acute visual loss due to the degeneration of retinal ganglion cells. In this study, we describe a patient carrying a rare missense heteroplasmic variant in MT-ND1,
Externí odkaz:
https://doaj.org/article/12ee8ca3d0004c67b8c245a36ed355c8
Publikováno v:
Cell Stress, Vol 6, Iss 4, Pp 45-60 (2022)
Glioblastoma (GBM) is a fatal disease with recurrences often associated with radioresistance. Although often effective at treating newly diagnosed GBM, increasing evidence suggests that radiotherapy-induced alterations in tumor metabolism promote GBM
Externí odkaz:
https://doaj.org/article/8c00afdcd8c1420bbb9f2be14bd325be
Autor:
Rosella Scrima, Olga Cela, Michela Rosiello, Ari Qadir Nabi, Claudia Piccoli, Giuseppe Capitanio, Francesco Antonio Tucci, Aldo Leone, Giovanni Quarato, Nazzareno Capitanio
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15144 (2023)
The current view of the mitochondrial respiratory chain complexes I, III and IV foresees the occurrence of their assembly in supercomplexes, providing additional functional properties when compared with randomly colliding isolated complexes. Accordin
Externí odkaz:
https://doaj.org/article/310e2fe04f574e188286bb9eea944799
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15229 (2023)
The study of the supramolecular organization of the mitochondrial oxidative phosphorylation system (OXPHOS) in various eukaryotes has led to the accumulation of a considerable amount of data on the composition, stoichiometry, and architecture of its
Externí odkaz:
https://doaj.org/article/54b2be1a33194c5f81839640db021b72