In Silico, in Vitro, and in Vivo Evaluation of Precipitation Inhibitors in Supersaturated Lipid-Based Formulations of Venetoclax

Autor: Martin Kuentz, Niklas J. Koehl, Daniel J. Price, René Holm, Laura J. Henze, Harriet Bennett-Lenane, Waleed Faisal, Brendan T. Griffin

Publikováno v: Koehl, N J, Henze, L J, Bennett-Lenane, H, Faisal, W, Price, D J, Holm, R, Kuentz, M & Griffin, B T 2021, ' In Silico, in Vitro, and in Vivo Evaluation of Precipitation Inhibitors in Supersaturated Lipid-Based Formulations of Venetoclax ', Molecular Pharmaceutics, vol. 18, no. 6, pp. 2174-2188 . https://doi.org/10.1021/acs.molpharmaceut.0c00645
Molecular Pharmaceutics

The concept of using precipitation inhibitors (PIs) to sustain supersaturation is well established for amorphous formulations but less in the case of lipid-based formulations (LBF). This study applied a systematic in silico-in vitro-in vivo approach

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2776c425b60b01e7e53c4192e741d5b
https://findresearcher.sdu.dk:8443/ws/files/183357915/acs.molpharmaceut.0c00645.pdf

Lipid-based systems with precipitation inhibitors as formulation approach to improve the drug bioavailability and/or lower its dose: a review.

Autor: Kovačević, Mila, Gašperlin, Mirjana, Pobirk, Alenka Zvonar

Publikováno v: Acta Pharmaceutica; Jun2024, Vol. 74 Issue 2, p201-227, 27p