Zobrazeno 1 - 10
of 1 610
pro vyhledávání: '"super‐enhancer"'
Autor:
Dandan Chen, Rongping Yin
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Engrailed 2 (EN2) is a homeodomain-containing protein whose aberrant expression is observed in various cancer types, yet its role in breast cancer remains unclear. This study investigates the roles and mechanisms of EN2 in breast cancer prog
Externí odkaz:
https://doaj.org/article/9e31a1084f7c4d348762a6fcc5e5cf4e
Autor:
Qingling He, Jianyang Hu, Hao Huang, Tan Wu, Wenxiu Li, Saravanan Ramakrishnan, Yilin Pan, Kui Ming Chan, Liang Zhang, Mengsu Yang, Xin Wang, Y. Rebecca Chin
Publikováno v:
Epigenetics & Chromatin, Vol 17, Iss 1, Pp 1-14 (2024)
Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with an unmet clinical need, but its epigenetic regulation remains largely undefined. By performing multiomic profiling, we recently revealed distinct super-enhan
Externí odkaz:
https://doaj.org/article/3bdf41726eb64b13ab397d8213e002d9
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-18 (2024)
Abstract Background Our research endeavored to develop a robust predictive signature grounded in super-enhancer-related genes (SERGs), with the dual objectives of forecasting survival outcomes and evaluating the tumor immune microenvironment (TiME) i
Externí odkaz:
https://doaj.org/article/20e300dcb63a4a4fb93c36b6bbc2a797
Autor:
Hongying Ma, Jian Qu, Zicheng Pang, Jian Luo, Min Yan, Weixin Xu, Haihui Zhuang, Linxin Liu, Qiang Qu
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-23 (2024)
Abstract The hallmarks of stem cells, such as proliferation, self-renewal, development, differentiation, and regeneration, are critical to maintain stem cell identity which is sustained by genetic and epigenetic factors. Super-enhancers (SEs), which
Externí odkaz:
https://doaj.org/article/be266dfa15144a5890db9ff18ca872f9
Autor:
Yi Wang, Shuwen Chen, Min Xue, Jinhu Ma, Xinrui Yi, Xinyu Li, Xuejin Lu, Meizi Zhu, Jin Peng, Yunshu Tang, Yaling Zhu
Publikováno v:
Animal Bioscience, Vol 37, Iss 8, Pp 1317-1332 (2024)
Objective Rare study of the non-coding and regulatory regions of the genome limits our ability to decode the mechanisms of fatty liver hemorrhage syndrome (FLHS) in chickens. Methods Herein, we constructed the high-fat diet-induced FLHS chicken model
Externí odkaz:
https://doaj.org/article/ed39f2ac5f104c6b93c7b5e5225f148b
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-22 (2024)
Abstract Background Presbycusis, also referred to as age-related hearing loss (ARHL), is a condition that results from the cumulative effects of aging on an individual's auditory capabilities. Given the limited understanding of epigenetic mechanisms
Externí odkaz:
https://doaj.org/article/12bf5a9dd83945419c31d50a7b145a58
Autor:
Siyuan Yan, Zhaonan Liu, Teng Wang, Yi Sui, Xiangsong Wu, Jiayi Shen, Peng Pu, Yang Yang, Sizhong Wu, Shimei Qiu, Ziyi Wang, Xiaoqing Jiang, Feiling Feng, Guoqiang Li, FaTao Liu, Chaoxian Zhao, Ke Liu, Jiayi Feng, Maolan Li, Kwan Man, Chaochen Wang, Yujie Tang, Yingbin Liu
Publikováno v:
Advanced Science, Vol 11, Iss 47, Pp n/a-n/a (2024)
Abstract Gallbladder cancer (GBC) is a highly aggressive malignancy lacking clinically available targeted therapeutic agents. Super‐enhancers (SEs) are crucial epigenetic cis‐regulatory elements whose extensive reprogramming drives aberrant trans
Externí odkaz:
https://doaj.org/article/89de29b6adae4900b53e6052f06b9a5f
Autor:
Xiaoying Wang, Xiangrui Zhu, Wei Huang, Zhaosi Wang, Jian Mei, Langlin Ou, Yunwei Chen, Cui Ma, Lixin Zhang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 21 (2024)
Background Unveiling pro‐proliferation genes involved in crosstalk between pulmonary artery endothelial cells and pulmonary artery smooth muscle cells (PASMCs) are important to improving the therapeutic outcome of pulmonary hypertension (PH). Altho
Externí odkaz:
https://doaj.org/article/7bb3b92dd680443fa3180d21e0a915ca
Autor:
Jin Li, Yuhan Wang, Ziyu Wang, Yuxiang Wei, Pengfei Diao, Yaping Wu, Dongmiao Wang, Hongbing Jiang, Yanling Wang, Jie Cheng
Publikováno v:
Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)
Abstract Super‐enhancers (SEs) have been recognized as key epigenetic regulators underlying cancer stemness and malignant traits by aberrant transcriptional control and promising therapeutic targets against human cancers. However, the SE landscape
Externí odkaz:
https://doaj.org/article/ea5358db53694c92a7f1a3e485c8e055
Autor:
Xujin Wei, Jie Liu, Jia Cheng, Wangyu Cai, Wen Xie, Kang Wang, Lingyun Lin, Jingjing Hou, Jianchun Cai, Huiqin Zhuo
Publikováno v:
eLife, Vol 13 (2024)
Gastric cancer (GC) is a major cause of cancer-related mortality worldwide. Despite the widespread recognition of tumor immunotherapy in treating unresectable GC, challenges, including ineffective immunotherapy and drug resistance, persist. Therefore
Externí odkaz:
https://doaj.org/article/d6670c410b30435aa705cc4810b95748