Zobrazeno 1 - 10
of 123
pro vyhledávání: '"summary data-based mendelian randomization"'
Publikováno v:
Nutrition & Metabolism, Vol 21, Iss 1, Pp 1-9 (2024)
Abstract Background Despite the exploration of the connections between serum low-density lipoprotein cholesterol (LDL-C) levels and aneurisms in epidemiological studies, causality remains unclear. Therefore, this study aimed to assess the causal impa
Externí odkaz:
https://doaj.org/article/ab4cb828ba434f419d1e4624f2eaef6d
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-12 (2024)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a respiratory disorder of obscure etiology and limited treatment options, possibly linked to dysregulation in lipid metabolism. While several observational studies suggest that lipid-lowering
Externí odkaz:
https://doaj.org/article/c43af1f9153c4d3c9e3a77fabb06097f
Autor:
Yubiao Yang, Ping Hu, Qinnan Zhang, Boyuan Ma, Jinyu Chen, Bitao Wang, Jun Ma, Derong Liu, Jian Hao, Xianhu Zhou
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-13 (2024)
Abstract Background Gout is a prevalent manifestation of metabolic osteoarthritis induced by elevated blood uric acid levels. The purpose of this study was to investigate the mechanisms of gene expression regulation in gout disease and elucidate its
Externí odkaz:
https://doaj.org/article/03d4bc95c5af42a1b61164c7fb6bf3a2
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
Background and objectivesObservational studies have established a connection between body mass index (BMI) and an increased risk of cognitive decline. However, a comprehensive investigation into the causal relationships between BMI and cognitive func
Externí odkaz:
https://doaj.org/article/e947dc1374e2464e99dd2306646c9997
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease characterized by unexplained irreversible pulmonary fibrosis. Although the etiology of IPF is unclear, studies have shown that it is related to telomere
Externí odkaz:
https://doaj.org/article/4f42dc7acacc4066ab54c5a3ff62c397
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Background: Lung squamous cell carcinoma (LSCC) is a major subtype of lung cancer with poor prognosis and low survival rate. Compared with lung adenocarcinoma, yet no FDA-approved targeted-therapy has been found for lung squamous cell carcinoma.Metho
Externí odkaz:
https://doaj.org/article/a015e8f968e04e2593706eff262fcd23
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
BackgroundThis study aims to prioritize genes potentially involved in multifactorial or causal relationships with gout.MethodsUsing the Summary Data-based Mendelian Randomization (SMR) approach, this research analyzed expression quantitative trait lo
Externí odkaz:
https://doaj.org/article/c1d5c131468f4580b9decde2108f9a8a
Autor:
Sainan Zhang, Ping Wang, Lei Shi, Chao Wang, Zijun Zhu, Changlu Qi, Yubin Xie, Shuofeng Yuan, Liang Cheng, Xin Yin, Xue Zhang
Publikováno v:
Virus Research, Vol 342, Iss , Pp 199341- (2024)
Genome-wide association study (GWAS) analysis has exposed that genetic factors play important roles in COVID-19. Whereas a deeper understanding of the underlying mechanism of COVID-19 was hindered by the lack of expression of quantitative trait loci
Externí odkaz:
https://doaj.org/article/2adeba3346da4c3b9a4c2a8567c81e48
Autor:
Gerard Badia-Bringué, Maria Canive, Nora Fernandez-Jimenez, José Luis Lavín, Rosa Casais, Cristina Blanco-Vázquez, Patricia Vázquez, Almudena Fernández, Jose Ramón Bilbao, Joseba M. Garrido, Ramón A. Juste, Oscar González-Recio, Marta Alonso-Hearn
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract Genome-wide association studies (GWAS) have identified host genetic variants associated with paratuberculosis (PTB) susceptibility. Most of the GWAS-identified SNPs are in non-coding regions. Connecting these non-coding variants and downstre
Externí odkaz:
https://doaj.org/article/af6b21caaa5a42d5b19d550d12a0217b
Publikováno v:
Antioxidants, Vol 13, Iss 8, p 903 (2024)
Background: Oxidative stress (OS) is involved in the development of diabetes, but the genetic mechanisms are not completely understood. We integrated multi-omics data in order to explore the genetic relations between OS-related genes, diabetes mellit
Externí odkaz:
https://doaj.org/article/d2460e3cf04b4f8d8f05d21426d394ef