Zobrazeno 1 - 10
of 34
pro vyhledávání: '"sulphonyl fluoride"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Sulphur fluoride exchange (SuFEx) is a category of click chemistry that enables covalent linking of modular units through sulphur connective hubs. Here, we reported an efficient synthesis and in situ screening method for building a library of sulphon
Externí odkaz:
https://doaj.org/article/bb4c5948d926499ca421b0401a8f881a
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2099-2111 (2022)
Novel scaffolds are expected to treat Alzheimer’s disease, pyrazole-5-fluorosulfates were found as selective BuChE inhibitors. Compounds K1–K26 were assayed for ChE inhibitory activity, amongst them, compound K3 showed potent BuChE and hBuChE inh
Externí odkaz:
https://doaj.org/article/609e92067768441e9a26d2302814caec
Autor:
Chengyao Wu, Guijuan Zhang, Zai-Wei Zhang, Xia Jiang, Ziwen Zhang, Huanhuan Li, Hua-Li Qin, Wenjian Tang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1860-1873 (2021)
To discover novel scaffolds as leads against dementia, a series of δ-aryl-1,3-dienesulfonyl fluorides with α-halo, α-aryl and α-alkynyl were assayed for ChE inhibitory activity, in which compound A10 was identified as a selective BuChE inhibitor
Externí odkaz:
https://doaj.org/article/d7f8355becd94532881e4dcf903bb612
Akademický článek
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Autor:
Xia Jiang, Chengyao Wu, Zai-Wei Zhang, Huanhuan Li, Guijuan Zhang, Wen-Jian Tang, Hua-Li Qin, Ziwen Zhang
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1860-1873 (2021)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
To discover novel scaffolds as leads against dementia, a series of δ-aryl-1,3-dienesulfonyl fluorides with α-halo, α-aryl and α-alkynyl were assayed for ChE inhibitory activity, in which compound A10 was identified as a selective BuChE inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56eae79f43e87e1d235e08414443c4a
Akademický článek
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Autor:
Diego Sbardella, Alessandra di Masi, Giovanna De Simone, Magda Gioia, Giovanni Francesco Fasciglione, Massimo Coletta, Alessio Bocedi, Grazia R. Tundo, Donato Di Pierro, Paolo Ascenzi, Paolo Calligari, Chiara Ciaccio
Publikováno v:
Biochemical Pharmacology
Graphical abstract
In the Fall of 2019 a sudden and dramatic outbreak of a pulmonary disease (Coronavirus Disease COVID-19), due to a new Coronavirus strain (i.e., SARS-CoV-2), emerged in the continental Chinese area of Wuhan and quickly diffuse
In the Fall of 2019 a sudden and dramatic outbreak of a pulmonary disease (Coronavirus Disease COVID-19), due to a new Coronavirus strain (i.e., SARS-CoV-2), emerged in the continental Chinese area of Wuhan and quickly diffuse
Akademický článek
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Publikováno v:
Vaccine
Rabies is progressive fatal encephalitis. WHO estimates 55,000 rabies deaths and more than 10 million PEP every year world-wide. A variety of cell-culture derived vaccines are available for prophylaxis against rabies. However, their high cost restric
Akademický článek
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