Zobrazeno 1 - 10
of 3 023
pro vyhledávání: '"succinylation"'
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Hepatocellular carcinoma (HCC) remains one of the most prevalent malignant tumors globally, characterized by high incidence and mortality rates. Despite ongoing research, the underlying molecular mechanisms of HCC development are not yet ful
Externí odkaz:
https://doaj.org/article/8362886fee074c74b7aab22c4be506f2
Autor:
Xinnan Zhao, Xiaohan Yang, Cong Du, Huimin Hao, Shuang Liu, Gang Liu, Guangyin Zhang, Kai Fan, Jianmei Ma
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-21 (2024)
Abstract The aging of the central nervous system(CNS) is a primary contributor to neurodegenerative diseases in older individuals and significantly impacts their quality of life. Neuroinflammation, characterized by activation of microglia(MG) and rel
Externí odkaz:
https://doaj.org/article/dbae291de7374000832ddaf6484f46f4
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Lung cancer is a malignant tumor originating from the bronchial mucosa or gland of the lung. Recently, lidocaine, a widely used amide local anesthetic, was demonstrated to inhibit many cancer progression. This research was performed to explo
Externí odkaz:
https://doaj.org/article/05285d96efd64b5aa97cf2b40b701f3c
Autor:
Hussam Alsharif
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 38, Iss 1 (2024)
Lysine succinylation is a post-translational modification that occurs when a succinyl group bonds with a lysine residue and changes the polarity of lysine from positive to negative, causing significant changes in the structure and functioning of prot
Externí odkaz:
https://doaj.org/article/17a2fd4a78b843f58c8afdaa6785df53
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Long noncoding RNAs (lncRNAs) play vital regulatory functions in non-small cell lung cancer (NSCLC). Cisplatin (DDP) resistance has significantly decreased the effectiveness of DDP-based chemotherapy in NSCLC patients. This study
Externí odkaz:
https://doaj.org/article/543cf20db79a402ca36954aebf128cee
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionProtein acetylation is an extensively investigated post-translational modification (PTM). In addition to lysine acetylation, three new types of lysine acylations characterized by the presence of an acidic carboxylic group have been recent
Externí odkaz:
https://doaj.org/article/9cd9376429074334964eb0d1638690eb
Publikováno v:
Clinical and Experimental Hypertension, Vol 46, Iss 1 (2024)
ABSTRACTPurpose Hypertensive disorder complicating pregnancy (HDCP) is a serious clinical disorder syndrome during pregnancy. This study aims at finding novel targets for HDCP therapy.Methods HDCP-related mRNAs were firstly screened out and subjected
Externí odkaz:
https://doaj.org/article/f64dcb360dee4d5dae71930575250aa6
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
ABSTRACTSuccinylation modification involves in the progression of human cancers. The present study aimed to investigate the role of CPT1A, which is a succinyltransferase in the progression of prostate cancer (PCa). CCK-8 was used to detect the cell v
Externí odkaz:
https://doaj.org/article/cb5ecdfdd8e545689f50e93157a10ffb
Autor:
Qiwen Yu, Jiakai Zhang, Jiye Li, Yaodong Song, Jie Pan, Chaopeng Mei, Mengwei Cui, Qianqian He, Haifeng Wang, Huihui Li, Bo Cheng, Yan Zhang, Wenzhi Guo, Changju Zhu, Sanyang Chen
Publikováno v:
Advanced Science, Vol 11, Iss 39, Pp n/a-n/a (2024)
Abstract Acetaminophen (APAP) overdose is a major cause of drug‐induced liver injury. Sirtuins 5 (SIRT5) has been implicated in the development of various liver diseases. However, its involvement in APAP‐induced acute liver injury (AILI) remains
Externí odkaz:
https://doaj.org/article/c485edc72a664270873eff78763c1661
Publikováno v:
Clinical, Cosmetic and Investigational Dermatology, Vol Volume 17, Pp 1495-1504 (2024)
Yuehong Ma, Hongqin Chang Department of Dermatology, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of ChinaCorrespondence: Hongqin Chang, Department of Dermatology, The Affiliated Ch
Externí odkaz:
https://doaj.org/article/9903f38b57bc472e9bf8f37bb3e6446e