Insights into the Substrate Uptake Mechanism of Mycobacterium Tuberculosis Ribose 5-Phosphate Isomerase and Perspectives on Drug Development

Autor: Leonardo Bartkevihi, Ícaro P. Caruso, Bruna Martins, José R. M. Pires, Danielle M. P. Oliveira, Cristiane Dinis Anobom, Fabio C. L. Almeida

Publikováno v: Biophysica, Vol 3, Iss 1, Pp 139-157 (2023)

The active site of the dimeric ribose 5-phosphate isomerase B (RpiB) contains a solvent-exposed barrier formed by residues H12, R113, R137, and R141, which is closed upon the complexation of phosphate. The substrate ribose 5-phosphate (R5P) has to ov

Externí odkaz: https://doaj.org/article/b2d1450f87724db8880684554c44bac8

Hydrophobic Outer Membrane Pores Boost Testosterone Hydroxylation by Cytochrome P450 BM3 Containing Cells

Autor: Carolin Bertelmann, Magdalena Mock, Rainhard Koch, Andreas Schmid, Bruno Bühler

Publikováno v: Frontiers in Catalysis, Vol 2 (2022)

The implementation of biocatalytic steroid hydroxylation processes at an industrial scale still suffers from low conversion rates. In this study, we selected variants of the self-sufficient cytochrome P450 monooxygenase BM3 from Bacillus megaterium (

Externí odkaz: https://doaj.org/article/0f52d368b5134df4982d06d54daab5ab

Composition and Seasonality of Membrane Transporters in Marine Picoplankton

Autor: Åke Hagström, Ulla Li Zweifel, John Sundh, Christofer M. G. Osbeck, Carina Bunse, Johanna Sjöstedt, Bärbel Müller-Karulis, Jarone Pinhassi

Publikováno v: Frontiers in Microbiology, Vol 12 (2021)

In this study, we examined transporter genes in metagenomic and metatranscriptomic data from a time-series survey in the temperate marine environment of the Baltic Sea. We analyzed the abundance and taxonomic distribution of transporters in the 3μm�

Externí odkaz: https://doaj.org/article/70bbdaf4bc2b4d37a6a10c06a9dc2eda

Simultaneous real-time estimation of maximum substrate uptake capacity and yield coefficient in induced microbial cultures

Autor: Don Fabian Müller, Daniel Wibbing, Christoph Herwig, Julian Kager

Publikováno v: Müller, D F, Wibbing, D, Herwig, C & Kager, J 2023, ' Simultaneous real-time estimation of maximum substrate uptake capacity and yield coefficient in induced microbial cultures ', Computers and Chemical Engineering, vol. 173, 108203 . https://doi.org/10.1016/j.compchemeng.2023.108203

In this work we present a soft sensor to accurately estimate the yield coefficient 𝑌𝑋∕𝑆 and the substrate uptake capacity 𝑞𝑆𝑚𝑎𝑥 in a cultivation process using offgas measurements and a nonlinear state observer with an underl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2720076f219b320c7bffe924d11a6a9a
https://orbit.dtu.dk/en/publications/0c248b7d-bf0c-43c4-a5b3-532cb4003c87

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