Zobrazeno 1 - 10
of 2 010
pro vyhledávání: '"substrate stiffness"'
Autor:
Manijeh Khanmohammadi, Habiba Danish, Nadia Chandra Sekar, Sergio Aguilera Suarez, Chanly Chheang, Karlheinz Peter, Khashayar Khoshmanesh, Sara Baratchi
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Neutrophils, the most abundant leukocytes circulating in blood, contribute to host defense and play a significant role in chronic inflammatory disorders. They can release their DNA in the form of extracellular traps (NETs), which
Externí odkaz:
https://doaj.org/article/3af4aa213671408c92e0267afd734f77
Publikováno v:
Taiyuan Ligong Daxue xuebao, Vol 55, Iss 2, Pp 384-389 (2024)
Purposes Osteoarthritis (OA) is a degenerative joint disease that commonly occurs in middle-aged and elderly people. Mechanical microenvironment is one of the most significant factors in the development of OA. However, when the mechanical microenviro
Externí odkaz:
https://doaj.org/article/9ee2493e0f724f2197fe8aa01df558b6
Autor:
Lasse Wolfram, Clara Gimpel, Melanie Schwämmle, Simon J. Clark, Daniel Böhringer, Günther Schlunck
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Alterations in the structure and composition of Bruch’s membrane (BrM) and loss of retinal pigment epithelial (RPE) cells are associated with various ocular diseases, notably age-related macular degeneration (AMD) as well as several inheri
Externí odkaz:
https://doaj.org/article/423932a85ad744eea94258f544c5be04
Autor:
Ana Monserrat Vela-Alcántara, Juan Santiago-García, Madeleine Barragán-Palacios, Aylin León-Chacón, Marilú Domínguez-Pantoja, Irene Barceinas-Dávila, Enrique Juárez-Aguilar, Elisa Tamariz
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Physical changes in the tumor microenvironment, such as increased stiffness, regulate cancer hallmarks and play an essential role in gene expression, cell morphology, migration, and malignancy. However, the response of cancer cells to stiffness is no
Externí odkaz:
https://doaj.org/article/5861452d373247fd85df1f687d89705b
Autor:
Zhang Yang, Tawiah Godfred K, Zhang Yanjun, Wang Xiaohu, Wei Xiaochun, Chen Weiyi, Qiao Xiaohong, Zhang Quanyou
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 55, Pp 1987-1998 (2023)
Osteoarthritis (OA) is a chronic disease and is difficult to cure. Chondrocytes are highly mechanosensitive. Therefore, mechanical therapies have received attention as a therapeutic direction for OA. The stiffness, as a critical cue of the extracellu
Externí odkaz:
https://doaj.org/article/6327a13672f14e2ab8a40d295ab9052b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Plastin-3 (PLS3) is a calcium-sensitive actin-bundling protein that has recently been linked to the development of childhood-onset osteoporosis. Clinical data suggest that PLS3 mutations lead to a defect in osteoblast function, however the underlying
Externí odkaz:
https://doaj.org/article/38f9f057efb6490cba2c215e65599369
Autor:
Mohammad Hamrangsekachaee, Ke Wen, Narges Yazdani, Rebecca K. Willits, Sidi A. Bencherif, Eno E. Ebong
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Glycocalyx (GCX) is a carbohydrate-rich structure that coats the surface of endothelial cells (ECs) and lines the blood vessel lumen. Mechanical perturbations in the vascular environment, such as blood vessel stiffness, can be transduced and sent to
Externí odkaz:
https://doaj.org/article/55dfc8a990464726a1d6332cc057b243
Autor:
Guanjie JIA, Jinlong KONG, Shasha YANG, Yuyuan ZHANG, Huiyuan YANG, Yaoyao DU, Kaiqun WANG, Zhihuan ZHAO, Weiyi CHEN
Publikováno v:
Taiyuan Ligong Daxue xuebao, Vol 54, Iss 1, Pp 178-185 (2023)
Doxorubicin is a broad-spectrum chemotherapy drug commonly used in clinical practice. Improving the delivery efficiency of doxorubicin can help improve the therapeutic effect of tumor and reduce the corresponding side effects. The delivery of doxorub
Externí odkaz:
https://doaj.org/article/e5eacaf47ba4436ebf30b74c1b4bf2de
Autor:
Sofia Ribeiro, Eugenia Pugliese, Stefanie H. Korntner, Emanuel M. Fernandes, Manuela E. Gomes, Rui L. Reis, Alan O'Riordan, Yves Bayon, Dimitrios I. Zeugolis
Publikováno v:
Engineering in Life Sciences, Vol 22, Iss 10, Pp 619-633 (2022)
Abstract The combined effect of surface topography and substrate rigidity in stem cell cultures is still under‐investigated, especially when biodegradable polymers are used. Herein, we assessed human bone marrow stem cell response on aliphatic poly
Externí odkaz:
https://doaj.org/article/feabdfdf044a46209fca24b5451c9ab8
Autor:
Gloriani Sánchez Marrero, Nicolas Villa-Roel, Feifei Li, Christian Park, Dong-Won Kang, Katherine E. Hekman, Hanjoong Jo, Luke P. Brewster
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Peripheral arterial disease (PAD) is an age-related medical condition affecting mostly muscular arteries of the limb. It is the 3rd leading cause of atherosclerotic morbidity. The mechanical environment of endothelial cells (ECs) in PAD is characteri
Externí odkaz:
https://doaj.org/article/61b2ee7740b748fc945a0bebbdf83520