Zobrazeno 1 - 10
of 752
pro vyhledávání: '"structure-guided"'
Autor:
Vijaykumar Karuppiah, Dhaval Sangani, Lorraine Whaley, Robert Pengelly, Pelin Uluocak, Ricardo J. Carreira, Miriam Hock, Pietro Della Cristina, Paulina Bartasun, Paula Dobrinic, Nicola Smith, Keir Barnbrook, Ross A. Robinson, Stephen Harper
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Specificity of a T cell receptor (TCR) is determined by the combination of its interactions to the peptide and human leukocyte antigen (HLA). TCR-based therapeutic molecules have to date targeted a single peptide in the context of a single H
Externí odkaz:
https://doaj.org/article/d5245e5725e8433484357359ff41b76a
Autor:
Emely V. Zeledon, Leigh A. Baxt, Tanweer A. Khan, Mayako Michino, Michael Miller, David J. Huggins, Caroline S. Jiang, Leslie B. Vosshall, Laura B. Duvall
Publikováno v:
Parasites & Vectors, Vol 17, Iss 1, Pp 1-12 (2024)
Abstract Background Female Aedes aegypti mosquitoes can spread disease-causing pathogens when they bite humans to obtain blood nutrients required for egg production. Following a complete blood meal, host-seeking is suppressed until eggs are laid. Neu
Externí odkaz:
https://doaj.org/article/b21dceefdf9643779d97fcff213cb8ff
Autor:
Zhang, Tao 1, 8, Wang, Pengyu 2, 8, Zhou, Hailing 1, 3, 8, Wei, Bingyan 2, 8, Zhao, Yanling 4, Li, Jiahui 1, Zhang, Min 5, Wu, Wenjuan 5, Lan, Lefu 2, 3, Gan, Jianhua 6, Yang, Cai-Guang 1, 2, 3, 4, 7, 9, ∗
Publikováno v:
In Cell Reports Medicine 17 December 2024 5(12)
Autor:
Qin, Mingwei a, b, Ding, Ning a, b, Ma, Pengfei c, Jiang, Hongtao a, b, Li, Yu a, b, Chen, Peifang a, b, Wang, Zhouping a, b, d, e, f, ⁎, Yang, Junsong d, ⁎⁎
Publikováno v:
In Biosensors and Bioelectronics 1 March 2025 271
Autor:
Zhang, Xuan a, 1, Lun, Shichun b, 1, Li, Yu-Xin a, 1, Zhang, Wei a, Zhou, Ruo-Yi a, Liu, Ting a, Yang, Fan a, Tang, Jie c, Bishai, William R. b, ⁎, Yu, Li-Fang a, ⁎⁎
Publikováno v:
In European Journal of Medicinal Chemistry 5 February 2025 283
Autor:
Fenghua Wang, Weijie Zhou, Maohua Yang, Jinlu Niu, Wenjie Huang, Zhaofu Chen, Yuanyuan Chen, Dongdong Wang, Jun Zhang, Shaowen Wu, Shijuan Yan
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Aflatoxins (AFs) are highly carcinogenic metabolites produced by Aspergillus species that can contaminate critical food staples, leading to significant health and economic risks. The cytochrome P450 monooxygenase AflG catalyzes an early step in AF bi
Externí odkaz:
https://doaj.org/article/ec1fd327a4624b1a892ec4fc02fb5a37
Akademický článek
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Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major global health concern associated with millions of fatalities worldwide. Mutant variants of the virus have further exacerbated
Externí odkaz:
https://doaj.org/article/b3520895121849fda27e3c12e22c6687
Autor:
Souraya A. Domiati, Khaled H. Abd El Galil, Mohammed A. S. Abourehab, Tamer M. Ibrahim, Hanan M. Ragab
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2179-2190 (2022)
A structure-guided modelling approach using COX-2 as a template was used to investigate the effect of replacing the chloro atom located at the chlorophenyl ring of amide-linked bipyrazole moieties, aiming at attaining better anti-inflammatory effect
Externí odkaz:
https://doaj.org/article/0059908b01c2425ca1e9b5923f422ca4
Autor:
Frederik Peissert, Mattia Pedotti, Riccardo Corbellari, Luca Simonelli, Raoul De Gasparo, Elia Tamagnini, Louis Plüss, Abdullah Elsayed, Mattia Matasci, Roberto De Luca, Irene Cassaniti, Jose’ Camilla Sammartino, Antonio Piralla, Fausto Baldanti, Dario Neri, Luca Varani
Publikováno v:
Global Challenges, Vol 7, Iss 10, Pp n/a-n/a (2023)
Abstract Neutralizing monoclonal antibodies have achieved great efficacy and safety for the treatment of numerous infectious diseases. However, their neutralization potency is often rapidly lost when the target antigen mutates. Instead of isolating n
Externí odkaz:
https://doaj.org/article/9593fd1955cb41539ee907e8cc2b1f1c