Zobrazeno 1 - 10
of 193
pro vyhledávání: '"structure-based drug design (sbdd)"'
Autor:
Cihan Demir, Erman Salih Istifli
Publikováno v:
International Journal of Plant Based Pharmaceuticals, Vol 2, Iss 2, Pp 271-283 (2022)
Diabetes mellitus (DM) characterized by high blood sugar concentration is a major global public health problem and untreated DM results in blindness, kidney failure, heart attack, stroke, and lower extremity amputation. In this structure-based drug d
Externí odkaz:
https://doaj.org/article/17b9e9badf8444a689e4bcdafd5d9170
Akademický článek
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Autor:
Moroncini, Matteo Mozzicafreddo, Devis Benfaremo, Chiara Paolini, Silvia Agarbati, Silvia Svegliati Baroni, Gianluca
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9623
The platelet-derived growth factor receptor (PDGFR) is a membrane tyrosine kinase receptor involved in several metabolic pathways, not only physiological but also pathological, as in tumor progression, immune-mediated diseases, and viral diseases. Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::f723636bcd2ec46c65d78c711af76c31
Publikováno v:
Biomolecules, Vol 10, Iss 4, p 631 (2020)
G protein-coupled receptors (GPCRs) are major drug targets due to their ability to facilitate signal transduction across cell membranes, a process that is vital for many physiological functions to occur. The development of computational technology pr
Externí odkaz:
https://doaj.org/article/16ccf90bfb1141abab417acc94d912e1
Autor:
DEMİR, Cihan, İSTİFLİ, Erman Salih
Publikováno v:
Volume: 2, Issue: 2 271-283
International Journal of Plant Based Pharmaceuticals
International Journal of Plant Based Pharmaceuticals
Diabetes mellitus (DM) characterized by high blood sugar concentration is a major global public health problem and untreated DM results in blindness, kidney failure, heart attack, stroke, and lower extremity amputation. In this structure-based drug d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bf1aec1dceac37ab8cc969653eb33f
https://doi.org/10.29228/ijpbp.9
https://doi.org/10.29228/ijpbp.9
Autor:
So Yeon Kim, Eun Gyeong Yang
Publikováno v:
Molecules, Vol 20, Iss 11, Pp 20551-20568 (2015)
Hypoxia-inducible factor (HIF) prolyl hydroxylases (PHDs) are members of the 2-oxoglutarate dependent non-heme iron dioxygenases. Due to their physiological roles in regulation of HIF-1α stability, many efforts have been focused on searching for sel
Externí odkaz:
https://doaj.org/article/03fbc0f831fb4a519e0ad81b8c8ad62f
Autor:
Martins, João Paulo Machado
A esquistossomose é uma das principais causas de morbidade em países Tropicais e Subtropicais, gerando graves consequências socioeconômicas. Atualmente, os fármacos disponíveis para o tratamento da desta doença são praziquantel e oxamniquina,
Akademický článek
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Akademický článek
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Autor:
Paul Nimmer, Erwin R. Boghaert, Robin R. Frey, Phuong N Le, Andrew J. Souers, Peter Kovar, Wenqing Gao, Deepak Sampath, Dolores Diaz, Haichao Zhang, T. Matthew Hansen, Michael J. Mitten, Stephen K. Tahir, Russell A. Judge, Edna F. Choo, Yu Xiao, Shashank Shekhar, Xiaohong Song, George Doherty, Zhi-Fu Tao, Andrew S. Judd, Wayne J. Fairbrother, Michael D. Wendt, Steven W. Elmore, Kunzer Aaron R, Le Wang, Xilu Wang, Darren C. Phillips, Morey L. Smith, John A. Flygare, John Xue, Joel D. Leverson, Milan Bruncko, Chang H. Park, Nathaniel D. Catron
Publikováno v:
ACS Medicinal Chemistry Letters
Herein we describe the discovery of A-1331852, a first-in-class orally active BCL-XL inhibitor that selectively and potently induces apoptosis in BCL-XL-dependent tumor cells. This molecule was generated by re-engineering our previously reported BCL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85af09593f6d81ea66757099b5fec23d
http://europepmc.org/articles/PMC7549103
http://europepmc.org/articles/PMC7549103