Prediction of enzymatic pathways by integrative pathway mapping

Autor: Sara Calhoun, Magdalena Korczynska, Daniel J Wichelecki, Brian San Francisco, Suwen Zhao, Dmitry A Rodionov, Matthew W Vetting, Nawar F Al-Obaidi, Henry Lin, Matthew J O'Meara, David A Scott, John H Morris, Daniel Russel, Steven C Almo, Andrei L Osterman, John A Gerlt, Matthew P Jacobson, Brian K Shoichet, Andrej Sali

Publikováno v: eLife, Vol 7 (2018)

The functions of most proteins are yet to be determined. The function of an enzyme is often defined by its interacting partners, including its substrate and product, and its role in larger metabolic networks. Here, we describe a computational method

Externí odkaz: https://doaj.org/article/fd3b096083a24d889b6a4ac902e9dcb6

Prediction of enzymatic pathways by integrative pathway mapping.

Autor: Calhoun S; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States., Korczynska M; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States., Wichelecki DJ; Institute for Genomic Biology, University of Illinois, Urbana, United States.; Department of Biochemistry, University of Illinois, Urbana, United States.; Department of Chemistry, University of Illinois, Urbana, United States., San Francisco B; Institute for Genomic Biology, University of Illinois, Urbana, United States., Zhao S; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States., Rodionov DA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States.; A.A. Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia., Vetting MW; Department of Biochemistry, Albert Einstein College of Medicine, New York, United States., Al-Obaidi NF; Department of Biochemistry, Albert Einstein College of Medicine, New York, United States., Lin H; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States., O'Meara MJ; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States., Scott DA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States., Morris JH; Resource for Biocomputing, Visualization and Informatics, Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States., Russel D; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States., Almo SC; Department of Biochemistry, Albert Einstein College of Medicine, New York, United States., Osterman AL; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, United States., Gerlt JA; Institute for Genomic Biology, University of Illinois, Urbana, United States.; Department of Biochemistry, University of Illinois, Urbana, United States.; Department of Chemistry, University of Illinois, Urbana, United States., Jacobson MP; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States., Shoichet BK; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States., Sali A; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, United States.; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, United States.; California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, United States.

Publikováno v: ELife [Elife] 2018 Jan 29; Vol. 7. Date of Electronic Publication: 2018 Jan 29.