Zobrazeno 1 - 10
of 294 293
pro vyhledávání: '"structural Biology"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 892-904 (2024)
Next-generation genome sequencing has revolutionized genetic testing, identifying numerous rare disease-associated gene variants. However, to impute pathogenicity, computational approaches remain inadequate and functional testing of gene variant is r
Externí odkaz:
https://doaj.org/article/d683955f9e6141f5b9b6a1c520c3940f
Autor:
Juliano Morimoto, Zuzanna Pietras
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Amino acids are the building blocks of proteins and enzymes which are essential for life. Understanding amino acid usage offers insights into protein function and molecular mechanisms underlying life histories. However, genome-wide patterns
Externí odkaz:
https://doaj.org/article/93a65f5079a04e0cb1cf95d07ec35531
Autor:
Jinuk Kim, Chulwon Choi
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 10, Pp 11646-11664 (2024)
Neurodegenerative disorders, particularly Alzheimer’s and Parkinson’s diseases, continue to challenge modern medicine despite therapeutic advances. Orphan G-protein-coupled receptors (GPCRs) have emerged as promising targets in the central nervou
Externí odkaz:
https://doaj.org/article/594ecc28e93d4a6b8b45bb753d696dc2
Publikováno v:
Acta Materia Medica, Vol 3, Iss 3, Pp 345-348 (2024)
Recent groundbreaking advances in the structural biology of the glucose transporter 9 (GLUT9) and urate transporter 1 (URAT1) have provided critical insights into the molecular mechanisms underlying urate recognition and transport. Using cryo-electro
Externí odkaz:
https://doaj.org/article/0a508a2ca28a4a77a5daae21b9e39266
Publikováno v:
IUCrJ, Vol 11, Iss 5, Pp 871-877 (2024)
Identifying and characterizing metal-binding sites (MBS) within macromolecular structures is imperative for elucidating their biological functions. CheckMyMetal (CMM) is a web based tool that facilitates the interactive validation of MBS in structure
Externí odkaz:
https://doaj.org/article/9b1faae132454f2b898dab5374e35ffd
Publikováno v:
SynBio, Vol 2, Iss 3, Pp 298-310 (2024)
Thermal green protein Q66E (TGP-E) has previously shown increased thermal stability compared to thermal green protein (TGP), a thermal stable fluorescent protein produced through consensus and surface protein engineering. In this paper, we describe t
Externí odkaz:
https://doaj.org/article/66982479417a4741905e78ad9bed4be9
Autor:
Alexander M. Ille, Christopher Markosian, Stephen K. Burley, Michael B. Mathews, Renata Pasqualini, Wadih Arap
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Natural language-based generative artificial intelligence (AI) has become increasingly prevalent in scientific research. Intriguingly, capabilities of generative pre-trained transformer (GPT) language models beyond the scope of natural langu
Externí odkaz:
https://doaj.org/article/10e11cbd36b74d4f8c9029d6d1ab1092
Autor:
Tomasz Włodarski, Julian O. Streit, Alkistis Mitropoulou, Lisa D. Cabrita, Michele Vendruscolo, John Christodoulou
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Cryogenic electron microscopy (cryo-EM) has emerged as a powerful method for the determination of structures of complex biological molecules. The accurate characterisation of the dynamics of such systems, however, remains a challenge. To add
Externí odkaz:
https://doaj.org/article/34880de7ddfb434da7db67f9fc377c9f