Sequential Modulations of Tumor Vasculature and Stromal Barriers Augment the Active Targeting Efficacy of Antibody‐Modified Nanophotosensitizer in Desmoplastic Ovarian Carcinoma

Autor: Qiang Zhang, Bo Xu, Zenghui Wang, Yaoqi Wang, Fangjie Wan, Yulin Mo, Qingqing Yin, Yue Yan, Binlong Chen, Yiguang Wang, Siling Wang

Publikováno v: Advanced Science
Advanced Science, Vol 8, Iss 3, Pp n/a-n/a (2021)

Active‐targeted nanoparticles are attractive carriers due to their potentials to facilitate specific delivery of drugs into tumor cells while sparing normal cells. However, the therapeutic outcomes of active‐targeted nanomedicines are hampered by

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http://europepmc.org/articles/PMC7856881

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Sequential Modulations of Tumor Vasculature and Stromal Barriers Augment the Active Targeting Efficacy of Antibody-Modified Nanophotosensitizer in Desmoplastic Ovarian Carcinoma.

Autor: Yan Y; School of Pharmacy Shenyang Pharmaceutical University Shenyang Liaoning 110016 China.; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical Sciences Peking University Beijing 100191 China.; State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China., Chen B; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical Sciences Peking University Beijing 100191 China.; State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China., Wang Z; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical Sciences Peking University Beijing 100191 China.; State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China., Yin Q; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical Sciences Peking University Beijing 100191 China.; State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China., Wang Y; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical Sciences Peking University Beijing 100191 China.; State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China., Wan F; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical Sciences Peking University Beijing 100191 China.; State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China., Mo Y; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical Sciences Peking University Beijing 100191 China.; State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China., Xu B; State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China., Zhang Q; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical Sciences Peking University Beijing 100191 China.; State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China., Wang S; School of Pharmacy Shenyang Pharmaceutical University Shenyang Liaoning 110016 China., Wang Y; Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems School of Pharmaceutical Sciences Peking University Beijing 100191 China.; State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 China.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2020 Dec 23; Vol. 8 (3), pp. 2002253. Date of Electronic Publication: 2020 Dec 23 (Print Publication: 2021).