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SARS-CoV-2 infection activates the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in the lung: a review

Autor: Gislei F. Aragão, Sthefane G. Feitosa, Herlice Do Nascimento Veras, Cícero Gilmário A. P. de Lima Filho, Karinne da S. Assunção, Luana M. Arrais, Sara Lívia M. Teixeira

Publikováno v: Exploration of Immunology, Vol 3, Iss 1, Pp 56-69 (2023)

The infection of COVID-19 is directly linked to the destruction of lung epithelial cells, and the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS-STING) system has been implicated in the pathology

Externí odkaz: https://doaj.org/article/284ef1cc4ca0460e9eb368adf125b397

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Stimulator of Interferon Genes Pathway Activation through the Controlled Release of STINGel Mediates Analgesia and Anti-Cancer Effects in Oral Squamous Cell Carcinoma

Autor: Minh Phuong Dong, Neeraja Dharmaraj, Estela Kaminagakura, Jianfei Xue, David G. Leach, Jeffrey D. Hartgerink, Michael Zhang, Hana-Joy Hanks, Yi Ye, Bradley E. Aouizerat, Kyle Vining, Carissa M. Thomas, Sinisa Dovat, Simon Young, Chi T. Viet

Publikováno v: Biomedicines, Vol 12, Iss 4, p 920 (2024)

Oral squamous cell carcinoma (OSCC) presents significant treatment challenges due to its poor survival and intense pain at the primary cancer site. Cancer pain is debilitating, contributes to diminished quality of life, and causes opioid tolerance. T

Externí odkaz: https://doaj.org/article/6e08a52ce46a4c4ebfc4aafaca817580

[Research progress on the cyclic GMP-AMP synthase stimulator of interferon genes pathway in respiratory diseases].

Autor: Qian JH; Department of Respiratory and Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China., Ye L; Department of Respiratory and Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China., Tan Y; Department of Respiratory and Critical Care Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.

Publikováno v: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases [Zhonghua Jie He He Hu Xi Za Zhi] 2024 Mar 12; Vol. 47 (3), pp. 252-258.