Zobrazeno 1 - 10
of 110
pro vyhledávání: '"stem cell memory"'
Autor:
O’Sullivan, Aine 1, Case, Sarah 1, 3, McCrudden, Aisling 1, 3, Hackett, Emer 1, Gallagher, Louise 1, Martin, Darren 1, Johnson, Gillian P. 1, Mahadik, Kirti 1, Kienzle, Thomas 1, Lim, Jude Kevin 1, Nashat, Aya 1, Srinivasan, Kartik 1, Lowdell, Mark W. 2, O’Flynn, Lisa 1, Frankish, Jamie 1, ∗
Publikováno v:
In Molecular Therapy - Methods & Clinical Development 13 March 2025 33(1)
Autor:
Dan Cappabianca, Dan Pham, Matthew H. Forsberg, Madison Bugel, Anna Tommasi, Anthony Lauer, Jolanta Vidugiriene, Brookelyn Hrdlicka, Alexandria McHale, Quaovi H. Sodji, Melissa C. Skala, Christian M. Capitini, Krishanu Saha
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101249- (2024)
Manufacturing chimeric antigen receptor (CAR) T cell therapies is complex, with limited understanding of how medium composition impacts T cell phenotypes. CRISPR-Cas9 ribonucleoproteins can precisely insert a CAR sequence while disrupting the endogen
Externí odkaz:
https://doaj.org/article/74f39a1628344c7f928bd6f3024b4800
Autor:
Alexander Kirchmair, Niloofar Nemati, Giorgia Lamberti, Marcel Trefny, Anne Krogsdam, Anita Siller, Paul Hörtnagl, Petra Schumacher, Sieghart Sopper, Adolf Sandbichler, Alfred Zippelius, Bart Ghesquière, Zlatko Trajanoski
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionNaïve T cells remain in an actively maintained state of quiescence until activation by antigenic signals, upon which they start to proliferate and generate effector cells to initiate a functional immune response. Metabolic reprogramming
Externí odkaz:
https://doaj.org/article/25c2a6a3518341a0aa6a96e79c0963f8
Akademický článek
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Akademický článek
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Autor:
Kayoko Nakamura, Shigeki Yagyu, Shogo Hirota, Akimasa Tomida, Makoto Kondo, Tomokuni Shigeura, Aiko Hasegawa, Miyuki Tanaka, Yozo Nakazawa
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 315-324 (2021)
The quality of chimeric antigen receptor (CAR)-T cell products, including the expression of memory and exhaustion markers, has been shown to influence their long-term functionality. The manufacturing process of CAR-T cells should be optimized to prev
Externí odkaz:
https://doaj.org/article/5f1ac6aebebe4c0ca7a02e0c5140b8d4
Autor:
Hiroshi Kubo, Shigeki Yagyu, Kayoko Nakamura, Kumiko Yamashima, Akimasa Tomida, Ken Kikuchi, Tomoko Iehara, Yozo Nakazawa, Hajime Hosoi
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 646-658 (2021)
Ephrin type-B receptor 4 (EPHB4), expressed in tumors including rhabdomyosarcoma, is a suitable target for chimeric antigen receptor (CAR)-T cells. Ligand-independent activation of EPHB4 causes cell proliferation and malignant transformation in rhabd
Externí odkaz:
https://doaj.org/article/0c34536b5fab4fecb261fa8e8d6c677b
Publikováno v:
Immunological Medicine, Vol 43, Iss 1, Pp 1-9 (2020)
CD8+T cells are important in protective immunity against intracellular pathogens and tumors. In chronic infections or cancer, CD8+T cells are constantly exposed to antigens and inflammatory signals. Such excessive and constitutive signals lead to the
Externí odkaz:
https://doaj.org/article/76abc1a5fe264fd2b979846138d305d8
Autor:
Masaya Suematsu, Shigeki Yagyu, Nobuyoshi Nagao, Susumu Kubota, Yuto Shimizu, Miyuki Tanaka, Yozo Nakazawa, Toshihiko Imamura
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The quality of chimeric antigen receptor (CAR)-T cell products, namely, memory and exhaustion markers, affects the long-term functionality of CAR-T cells. We previously reported that piggyBac (PB) transposon-mediated CD19 CAR-T cells exhibit a memory
Externí odkaz:
https://doaj.org/article/0d6dd13d416c422a87da5c0abb66c738
Akademický článek
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