The atorvastatin metabolite pattern in muscle tissue and blood plasma is associated with statin muscle side effects in patients with coronary heart disease; An exploratory case-control study

Autor: Trine Lauritzen, John Munkhaugen, Stein Bergan, Kari Peersen, Anja Camilla Svarstad, Anders M. Andersen, Jens Pahnke, Einar Husebye, Nils Tore Vethe

Publikováno v: Atherosclerosis Plus, Vol 55, Iss , Pp 31-38 (2024)

Background and aims: Statin-associated muscle symptoms (SAMS) is a prevalent cause of statin discontinuation. It is challenging and time-consuming for clinicians to assess whether symptoms are caused by the statin or not, and diagnostic biomarkers ar

Externí odkaz: https://doaj.org/article/f98394738ee04db2a3ec9c22ef5ac108

A practical algorithm for the management of patients with statin-associated muscle symptoms

Autor: Loukianos S. Rallidis

Publikováno v: Hellenic Journal of Cardiology, Vol 61, Iss 2, Pp 137-140 (2020)

Summary: Statin-associated muscle symptoms (SAMS) are the most frequent clinically relevant adverse effects of statins causing discontinuation of statin treatment, and subsequent increase in cardiovascular events. The incidence of SAMS in clinical pr

Externí odkaz: https://doaj.org/article/78e27cf3c7264ea295c357f073a560fe

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Prolonged Moderate-Intensity Exercise Does Not Increase Muscle Injury Markers in Symptomatic or Asymptomatic Statin Users

Autor: Neeltje A.E. Allard, Lando Janssen, Bart Lagerwaard, Malou A.H. Nuijten, Coen C.W.G. Bongers, Richard J. Rodenburg, Paul D. Thompson, Thijs M.H. Eijsvogels, Willem J.J. Assendelft, Tom J.J. Schirris, Silvie Timmers, Maria T.E. Hopman

Publikováno v: Journal of the American College of Cardiology, 81, 14, pp. 1353-1364
Journal of the American College of Cardiology, 81(14), 1353-1364
Journal of the American College of Cardiology, 81, 1353-1364
Journal of the American College of Cardiology 81 (2023) 14

Item does not contain fulltext BACKGROUND: Statin use may exacerbate exercise-induced skeletal muscle injury caused by reduced coenzyme Q10 (CoQ10) levels, which are postulated to produce mitochondrial dysfunction. OBJECTIVES: We determined the effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da3fa3d17920457575b7f7050b5de821
https://repository.ubn.ru.nl/handle/2066/291737