Zobrazeno 1 - 10
of 542
pro vyhledávání: '"sqstm1/p62"'
Autor:
Wenyuan Hou, Peng Peng, Fangjun Xiao, Jiaqing Tian, Xianshun He, Shun Lu, Huan Xiao, Mincong He, Qiushi Wei
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Autophagy is closely associated with the onset and progression of steroid-induced osteonecrosis of the femoral head (SIONFH). SQSTM1/p62 is an important indicator of autophagic activity. The aim of this study was to investigate the role of S
Externí odkaz:
https://doaj.org/article/8191cf7165004e77bf45b75994df8aa1
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Macrophages act as the first immune defense line of the host against Mycobacterium tuberculosis (Mtb). A previous study showed that circRNA_SLC8A1 was significantly upregulated in Mtb-infected macrophages, but its regulatory mechanism in ant
Externí odkaz:
https://doaj.org/article/50b09fa089cc4d55a67d6ce330495497
Autor:
Jing Feng, Yan Li, Yu Zhang, Shengnan Sun, Jian Sun, Quanlin Xu, Xingzhao Ji, Yi Liu, Qiang Wan
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background The autophagy adapter SQSTM1/p62 is crucial for maintaining homeostasis in various organs and cells due to its protein–protein interaction domains and involvement in diverse physiological and pathological processes. Vascular end
Externí odkaz:
https://doaj.org/article/f6181a889fb940d58565ec1a52d533a4
Autor:
Nadine Krämer, Uxía Gestal Mato, Steffi Krauter, Nicole Büscher, Ahmad Afifi, Lina Herhaus, Luise Florin, Bodo Plachter, Christine Zimmermann
Publikováno v:
Viruses, Vol 16, Iss 9, p 1440 (2024)
(1) Background: Intrinsic defense mechanisms are pivotal host strategies to restrict viruses already at early stages of their infection. Here, we addressed the question of how the autophagy receptor sequestome 1 (SQSTM1/p62, hereafter referred to as
Externí odkaz:
https://doaj.org/article/6f984e54535f4c32a5d1615bd24fc5c2
Autor:
Yan Xu, Ciba Zhu, Chenglou Zhu, Lingzhi Peng, Dandan Ji, Qiong Wu, Pengwei Bai, Zhaozhao Bai, Mingxu Da
Publikováno v:
Heliyon, Vol 10, Iss 3, Pp e24409- (2024)
Background: SQSTM1/p62 is an autophagy-related receptor protein that participates in regulating tumorigenesis and multiple signaling pathways. Gastric cancer (GC) is a common tumor in the digestive tract and continues to pose a significant threat to
Externí odkaz:
https://doaj.org/article/15da4275df364bffaca5dc9a3bc7f81d
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
Mitochondria are the center for energy production, cell fate determination and synthesis of essential biomolecules in cells. Hence, mitochondrial quality control mechanisms are essential for cellular health. Failure of these control mechanisms may le
Externí odkaz:
https://doaj.org/article/aa05872a62b74ba590d930d9915fe4df
Autor:
Jiafeng Chen, Zheng Gao, Xiaogang Li, Yinghong Shi, Zheng Tang, Weiren Liu, Xin Zhang, Ao Huang, Xuanming Luo, Qiang Gao, Guangyu Ding, Kang Song, Jian Zhou, Jia Fan, Xiutao Fu, Zhenbin Ding
Publikováno v:
Cancer Medicine, Vol 12, Iss 1, Pp 459-471 (2023)
Abstract Background SQSTM1/p62 is a selective autophagy receptor that regulates multiple signaling pathways participating in the initiation and progression of tumors. Metastasis is still the main cause for intrahepatic cholangiocarcinoma (ICC)‐asso
Externí odkaz:
https://doaj.org/article/9cda9be9bb884f46b45ffacfd36620a8
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 70-74 (2022)
Cell survival depends on dynamic interactions among the signaling pathways that control the endoplasmic reticulum (ER) stress response, macroautophagy/autophagy and apoptotic cell death. Our recent study reported an association of cytoplasmic SQSTM1/
Externí odkaz:
https://doaj.org/article/b24781601f794a34b35d35b8c3222a3a
Autor:
Ben B. Wang, Pirjo M. Apaja
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 260-263 (2022)
Protein quality control (PQC) is a conformational surveillance system critical to maintaining native protein composition in the cell. However, PQC mechanisms at the endo-lysosomal pathway especially toward membrane proteins and during cumulative endo
Externí odkaz:
https://doaj.org/article/abb59309d3204875bf19f066c72e1121
Autor:
Yinfeng Xu, Wei Wan
Publikováno v:
Nucleus, Vol 13, Iss 1, Pp 203-207 (2022)
Autophagy has emerged as a key regulator of cell metabolism. Recently, we have demonstrated that autophagy is involved in RNA metabolism by regulating ribosomal RNA (rRNA) synthesis. We found that autophagy-deficient cells display much higher 47S pre
Externí odkaz:
https://doaj.org/article/5f6f443ad0c540db9b7d45d3ea6bb289