Zobrazeno 1 - 10
of 1 199
pro vyhledávání: '"spreading depolarization"'
Autor:
Tsubasa Takizawa, Keiko Ihara, Miyuki Unekawa, Chisato Iba, Shizuko Kagawa, Narumi Watanabe, Shingo Nakayama, Kaori Sakurai, Naoki Miyazaki, Noriyuki Ishida, Ryo Takemura, Mamoru Shibata, Yoshikane Izawa, Shotaro Chubachi, Koichi Fukunaga, Jin Nakahara
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-7 (2024)
Abstract Background Patients with migraine are typically advised to avoid passive smoking because it may aggravate headaches and other health conditions. However, there is insufficient high-quality evidence on the association between passive smoking
Externí odkaz:
https://doaj.org/article/95ca109f005b473c8f7c6e45453e7aa2
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Migraine is among the most prevalent and burdensome neurological disorders in the United States based on disability-adjusted life years. Cortical spreading depolarization (SD) is the most likely electrophysiological cause of migra
Externí odkaz:
https://doaj.org/article/07705befc57744f9b1805340a5319971
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background The initiation of migraine headaches and the involvement of neuroinflammatory signaling between parenchymal and meningeal cells remain unclear. Experimental evidence suggests that a cascade of inflammatory signaling originating fr
Externí odkaz:
https://doaj.org/article/b8786fae32634f05b50c289f400808aa
Autor:
Anna A. Karan, Konstantin A. Gerasimov, Yulia S. Spivak, Elena M. Suleymanova, Lyudmila V. Vinogradova
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Neurogenic meningeal inflammation is regarded as a key driver of migraine headache. Multiple evidence show importance of inflammatory processes in the dura mater for pain generation but contribution of the leptomeninges is less cl
Externí odkaz:
https://doaj.org/article/33cc1ebd1d9f478ca80696a538f1a00d
Autor:
Yuya Hirayama, Hiroyuki Kida, Takao Inoue, Kazutaka Sugimoto, Fumiaki Oka, Satoshi Shirao, Hirochika Imoto, Sadahiro Nomura, Michiyasu Suzuki
Publikováno v:
IBRO Neuroscience Reports, Vol 16, Iss , Pp 609-621 (2024)
This study aimed to investigate the effects of focal brain cooling (FBC) on spreading depolarization (SD), which is associated with several neurological disorders. Although it has been studied from various aspects, no medication has been developed th
Externí odkaz:
https://doaj.org/article/524a58b2f8214b638f83ae69163e0c09
Autor:
Nico A. Jansen, Chelsey Linnenbank, Maarten Schenke, Rob A. Voskuyl, Maria S. Jorge, Georgii Krivoshein, Cor Breukel, Margot M. Linssen, Jill W.C. Claassens, Conny Brouwers, Sandra H. van Heiningen, Anders Heuck, Karin Lykke-Hartmann, Else A. Tolner, Arn M.J.M. van den Maagdenberg
Publikováno v:
Neurobiology of Disease, Vol 202, Iss , Pp 106714- (2024)
The mechanisms of initiation of spreading depolarization (SD) are understudied due to a paucity of disease models with spontaneously occurring events. We here present a novel mouse model of familial hemiplegic migraine type 2 (FHM2), expressing the m
Externí odkaz:
https://doaj.org/article/06ea3f35c9c3417aa35517e998fb1500
Autor:
A. Zdunczyk, L. Schumm, S. O. A. Helgers, M. Nieminen-Kelhä, X. Bai, S. Major, J. P. Dreier, N. Hecht, Johannes Woitzik
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Spreading depolarizations (SDs) occur frequently in patients with malignant hemispheric stroke. In animal-based experiments, SDs have been shown to cause secondary neuronal damage and infarct expansion during the initial period of infarct pr
Externí odkaz:
https://doaj.org/article/26ec4eadedf041c0a187040eaf9347f5
Autor:
Balázs Pál
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 12, Pp 2602-2612 (2024)
Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extrasynaptic N-methyl-D-aspartate receptors with the contribution of astrocytes. These events are significantly slower than the e
Externí odkaz:
https://doaj.org/article/59f7be680dd64bf2b2a3bd2331f123db
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 7, Pp 1509-1516 (2024)
Gabapentinoid drugs (pregabalin and gabapentin) have been successfully used in the treatment of neuropathic pain and in focal seizure prevention. Recent research has demonstrated their potent activities in modulating neurotransmitter release in neuro
Externí odkaz:
https://doaj.org/article/0e5479c5e3494919858dd82a08dba97d
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background Spreading depolarization (SD), underlying mechanism of migraine aura and potential activator of pain pathways, is known to elicit transient local silencing cortical activity. Sweeping across the cortex, the electrocorticographic d
Externí odkaz:
https://doaj.org/article/0d437c22f5f8433b9b04b82f915ad2e7