The ubiquitin ligase FBXW7 targets the centriolar assembly protein HsSAS-6 for degradation and thereby regulates centriole duplication

Autor: Ria Gupta, Sreeja V. Nair, Aneesh Chandrasekharan, Binshad Badarudeen, Tapas Manna

Publikováno v: J Biol Chem

Formation of a single new centriole from a pre-existing centriole is strictly controlled to maintain correct centrosome number and spindle polarity in cells. However, the mechanisms that govern this process are incompletely understood. Here, using se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa1177e2ca5a4e69b5590a7137e42fd
https://doi.org/10.1074/jbc.ac119.012178

The evolutionary conserved complex CEP90, FOPNL and OFD1 specifies the future location of centriolar distal appendages, and promotes their assembly

Autor: Pierrick Le Borgne, Logan Greibill, Marine Hélène Laporte, Michel Lemullois, Khaled Bouhouche, Mebarek Temagoult, Olivier Rosnet, Maeva Le Guennec, Laurent Lignières, Guillaume Chevreux, France Koll, Virginie Hamel, Paul Guichard, Anne-Marie Tassin

In metazoa, cilia assembly is a cellular process that starts with centriole to basal body maturation, migration to the cell surface and docking to the plasma membrane. Basal body docking involves the interaction of both the distal end of the basal bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59be36ec0fe2942bdf6305b942e76db5
https://doi.org/10.1101/2021.07.13.452210

Dynamics of centriole amplification in centrosome-depleted brain multiciliated progenitors

Autor: Marion Faucourt, Olivier Mercey, Alexia Mahuzier, Alice Meunier, Aurélien Fortoul, Amelie-Rose Boudjema, Nathalie Spassky, Adel Al Jord, Philippe Rostaing

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, ⟨10.1038/s41598-019-49416-2⟩

International audience; Reproductive and respiratory organs, along with brain ventricles, are lined by multiciliated epithelial cells (MCC) that generate cilia-powered fluid flows. MCC hijack the centrosome duplication pathway to form hundreds of cen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4a731f9a3bd4a5d36618f7bf21cfc8
https://doaj.org/article/567fd48fc7314b0484c43d9031f21fd7

Autophosphorylation-induced self-assembly and STIL-dependent reinforcement underlie Plk4’s ring-to-dot localization conversion around a human centriole

Autor: Eun Kyoung Ryu, Kyung S. Lee, Jung-Eun Park, Lingjun Meng, Jeong Kyu Bang, Kunio Nagashima, Ulrich Baxa

Publikováno v: Cell Cycle

Polo-like kinase 4 (Plk4) is a key regulator of centriole biogenesis. Studies have shown that Plk4 undergoes dynamic relocalization from a ring-like pattern around a centriole to a dot-like morphology at the procentriole assembly site and this event

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22bbea846222e74bb424d207571fb58
https://europepmc.org/articles/PMC7781628/

Tissue specific requirement of Drosophila Rcd4 for centriole duplication and ciliogenesis

Autor: David M. Glover, Marco Geymonat, Maria Giovanna Riparbelli, Nikola S. Dzhindzhev, Levente Kovacs, Giuliano Callaini, Veronica Persico, Agnieszka Fatalska, Pallavi Panda

Publikováno v: The Journal of Cell Biology

Panda et al. find that Rcd4 is required for centriole duplication and ciliogenesis in neurosensory organs but dispensable for spermatogenesis, indicating tissue specific requirements for centriole formation. Loading of Rcd4 and its binding partner An

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3bcc99b9c4299a0ac0545d1f6452090
https://resolver.caltech.edu/CaltechAUTHORS:20200624-070312017