Induction of FoxP3 Pre-mRNA Alternative Splicing to Enhance the Suppressive Activity of Regulatory T Cells from Amyotrophic Lateral Sclerosis Patients

Autor: Dmitry D. Zhdanov, Yulia A. Gladilina, Varvara G. Blinova, Anna A. Abramova, Anastasia N. Shishparenok, Daria D. Eliseeva

Publikováno v: Biomedicines, Vol 12, Iss 5, p 1022 (2024)

Forkhead box protein 3 (FoxP3) is a key transcription factor responsible for the development, maturation, and function of regulatory T cells (Tregs). The FoxP3 pre-mRNA is subject to alternative splicing, resulting in the translation of multiple spli

Externí odkaz: https://doaj.org/article/a415afbfc0eb449e821c2f9f842e92dd

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Modulators of alternative splicing as novel therapeutics in cancer

Autor: Sebastian Oltean

Publikováno v: Oltean, S 2015, ' Modulators of alternative splicing as novel therapeutics in cancer ', World Journal of Clinical Oncology, vol. 6, no. 5, pp. 92-95 . https://doi.org/10.5306/wjco.v6.i5.92
Sebastian Oltean

Alternative splicing (AS), the process of removing introns from pre-mRNA and re-arrangement of exons to give several types of mature transcripts, has been described more than 40 years ago. However, until recently, it has not been clear how extensive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3974d927b8b1af1fd7819b10b73162cf
https://research-information.bris.ac.uk/en/publications/0a78cc95-3e0c-43f8-b62b-eddbe5a91960

Modulation of Suppressive Activity and Proliferation of Human Regulatory T Cells by Splice-Switching Oligonucleotides Targeting FoxP3 Pre-mRNA.

Autor: Blinova VG; Laboratory of Medical Biotechnology, Institute of Biomedical Chemistry, Pogodinskaya st. 10/8, 119121 Moscow, Russia., Gladilina YA; Laboratory of Medical Biotechnology, Institute of Biomedical Chemistry, Pogodinskaya st. 10/8, 119121 Moscow, Russia., Abramova AA; Laboratory of Medical Biotechnology, Institute of Biomedical Chemistry, Pogodinskaya st. 10/8, 119121 Moscow, Russia.; Research Center of Neurology, Volokolamskoe Shosse, 80, 125367 Moscow, Russia., Eliseeva DD; Research Center of Neurology, Volokolamskoe Shosse, 80, 125367 Moscow, Russia., Vtorushina VV; National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of the Russian Federation, Laboratory of Clinical Immunology, Academician Oparin st. 4, 117997 Moscow, Russia., Shishparenok AN; Laboratory of Medical Biotechnology, Institute of Biomedical Chemistry, Pogodinskaya st. 10/8, 119121 Moscow, Russia., Zhdanov DD; Laboratory of Medical Biotechnology, Institute of Biomedical Chemistry, Pogodinskaya st. 10/8, 119121 Moscow, Russia.; Department of Biochemistry, People's Friendship University of Russia Named after Patrice Lumumba (RUDN University), Miklukho-Maklaya st. 6, 117198 Moscow, Russia.

Publikováno v: Cells [Cells] 2023 Dec 29; Vol. 13 (1). Date of Electronic Publication: 2023 Dec 29.