Zobrazeno 1 - 10
of 150
pro vyhledávání: '"splicing modulation"'
Autor:
Emilia Alors-Pérez, Sergio Pedraza-Arevalo, Ricardo Blázquez-Encinas, María Trinidad Moreno-Montilla, Víctor García-Vioque, Inmaculada Berbel, Raúl M. Luque, Bruno Sainz, Alejandro Ibáñez-Costa, Justo P. Castaño
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-16 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers worldwide, mainly due to its late diagnosis and lack of effective therapies, translating into a low 5-year 12% survival rate, despite extensive clinical efforts t
Externí odkaz:
https://doaj.org/article/a84214f7f90144bfaa84a7594e4529bf
Autor:
Nuria Suárez-Herrera, Catherina H. Z. Li, Nico Leijsten, Dyah W. Karjosukarso, Zelia Corradi, Femke Bukkems, Lonneke Duijkers, Frans P. M. Cremers, Carel B. Hoyng, Alejandro Garanto, Rob W. J. Collin
Publikováno v:
Cells, Vol 13, Iss 7, p 601 (2024)
Precision medicine is rapidly gaining recognition in the field of (ultra)rare conditions, where only a few individuals in the world are affected. Clinical trial design for a small number of patients is extremely challenging, and for this reason, the
Externí odkaz:
https://doaj.org/article/78195cd5174e462d99f4bd1b2718bd4e
Autor:
I Gede Putu Supadmanaba, Giulia Mantini, Ornella Randazzo, Mjriam Capula, Ittai B. Muller, Stella Cascioferro, Patrizia Diana, Godefridus J. Peters, Elisa Giovannetti
Publikováno v:
Epigenetics, Vol 17, Iss 4, Pp 381-404 (2022)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers because of diagnosis at late stage and inherent/acquired chemoresistance. Recent advances in genomic profiling and biology of this disease have not yet been translated to a rel
Externí odkaz:
https://doaj.org/article/95e67049e83d471fb22f4dea5968ac00
Akademický článek
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Autor:
Tomasz Z. Tomkiewicz, Sara E. Nieuwenhuis, Frans P. M. Cremers, Alejandro Garanto, Rob W. J. Collin
Publikováno v:
Cells, Vol 11, Iss 24, p 3947 (2022)
Stargardt disease is an inherited retinal disease caused by biallelic mutations in the ABCA4 gene, many of which affect ABCA4 splicing. In this study, nine antisense oligonucleotides (AONs) were designed to correct pseudoexon (PE) inclusion caused by
Externí odkaz:
https://doaj.org/article/d332dd9035664406962ab8615069c299
Akademický článek
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Akademický článek
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Publikováno v:
Applied Sciences, Vol 11, Iss 20, p 9621 (2021)
Coagulation factor V (FV) is a liver-derived protein encoded by the F5 gene. Alternative splicing of F5 exon 13 produces a low-abundance splicing isoform, known as FV-short, which binds the anticoagulant protein tissue factor pathway inhibitor (TFPI
Externí odkaz:
https://doaj.org/article/adca7fbc124c4c90a5230ed4184b7aa6
Akademický článek
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Autor:
Inge van der Werf, Phoebe K. Mondala, S. Kathleen Steel, Larisa Balaian, Luisa Ladel, Cayla N. Mason, Raymond H. Diep, Jessica Pham, Jacqueline Cloos, Gertjan J.L. Kaspers, Warren C. Chan, Adam Mark, James J. La Clair, Peggy Wentworth, Kathleen M. Fisch, Leslie A. Crews, Thomas C. Whisenant, Michael D. Burkart, Mary E. Donohoe, Catriona H.M. Jamieson
Publikováno v:
Cell reports. Medicine, vol 4, iss 3
Cell reports. Medicine, 4(3):100962. Cell Press
Cell Reports Medicine, 4(3):100962. Cell Press
van der Werf, I, Mondala, P K, Steel, S K, Balaian, L, Ladel, L, Mason, C N, Diep, R H, Pham, J, Cloos, J, Kaspers, G J L, Chan, W C, Mark, A, la Clair, J J, Wentworth, P, Fisch, K M, Crews, L A, Whisenant, T C, Burkart, M D, Donohoe, M E & Jamieson, C H M 2023, ' Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells ', Cell reports. Medicine, vol. 4, no. 3, 100962, pp. 100962 . https://doi.org/10.1016/j.xcrm.2023.100962, https://doi.org/10.1016/j.xcrm.2023.100962
Cell reports. Medicine, 4(3):100962. Cell Press
Cell Reports Medicine, 4(3):100962. Cell Press
van der Werf, I, Mondala, P K, Steel, S K, Balaian, L, Ladel, L, Mason, C N, Diep, R H, Pham, J, Cloos, J, Kaspers, G J L, Chan, W C, Mark, A, la Clair, J J, Wentworth, P, Fisch, K M, Crews, L A, Whisenant, T C, Burkart, M D, Donohoe, M E & Jamieson, C H M 2023, ' Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells ', Cell reports. Medicine, vol. 4, no. 3, 100962, pp. 100962 . https://doi.org/10.1016/j.xcrm.2023.100962, https://doi.org/10.1016/j.xcrm.2023.100962
Pediatric acute myeloid leukemia (pAML) is typified by high relapse rates and a relative paucity of somatic DNA mutations. Although seminal studies show that splicing factor mutations and mis-splicing fuel therapy-resistant leukemia stem cell (LSC) g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635fc2f87ba6c7bb45c6b2245e0c70ae
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150286973&origin=inward
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150286973&origin=inward