Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Metabolomic and lipidomic characterization of an X-chromosome deletion disorder in neural progenitor cells by UHPLC-HRMS

Autor: Richard A. Yost, Vanessa Y. Rubio, Hoda Safari Yazd, Timothy J. Garrett, Casey A. Chamberlain

Publikováno v: Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 20, Iss, Pp 11-24 (2021)
Journal of Mass Spectrometry and Advances in the Clinical Lab

Highlights • LC-HRMS Metabolomics and lipidomics applied in X-chromosome deletion disorders. • Partial or complete deletion of the X chromosome is a very rare condition. • Neural progenitor cells from a patient with a 7.3 megabase deletion at X

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09943261b4913c7a499e6c4602a9449
http://www.sciencedirect.com/science/article/pii/S2667145X21000092

Sphingosines Derived from Marine Sponge as Potential Multi-Target Drug Related to Disorders in Cancer Development

Autor: Renata Biegelmeyer, Rafael Schröder, Douglas F. Rambo, Roger R. Dresch, João L. F. Carraro, Beatriz Mothes, José Cláudio F. Moreira, Mário L. C. da Frota Junior, Amélia T. Henriques

Publikováno v: Marine Drugs, Vol 13, Iss 9, Pp 5552-5563 (2015)

Haliclona tubifera, marine sponge species abundant in Brazilian coastline, presents only a few papers published in the literature. Recently, we have reported the isolation of two modified C18 sphingoid bases: (2R,3R,6R,7Z)-2-aminooctadec-7-ene-1,3, 6

Externí odkaz: https://doaj.org/article/71f35c0f7a8b473ebbf0432b3ac426e1

A Mechanism-Based Sphingosine-1-phosphate Lyase Inhibitor

Autor: Daniel Riba, Eduardo Izquierdo, Mireia Casasampere, Gemma Fabriàs, Antonio Delgado, Josefina Casas, José Luis Abad, Juan Jesús López-González, Pilar Gema Rodríguez Ortega, Guillem X. Pons, Manuel Montejo

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

The synthesis of a series of vinylated analogues of sphingosine-1-phosphate together with their unambiguous configurational assignment by VCD methods is reported. Among them, compound RBM10-8 can irreversibly inhibit human sphingosine-1-phosphate lya

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36440eea6ba4da213345455ef8e2d2b1
http://hdl.handle.net/10261/212234

Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction

Autor: Jack Williams, Tulay Guran, Rathi Prasad, Teisha Y. Bradshaw, Avinaash Maharaj, Debora Braslavsky, Louise A. Metherell, Li F. Chan, J. Casas

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname

Deficiency in Sphingosine-1-phosphate lyase (S1P lyase) is associated with a multi-systemic disorder incorporating primary adrenal insufficiency (PAI), steroid resistant nephrotic syndrome and neurological dysfunction. Accumulation of sphingolipid in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9bb50e673f49a109768a5652271cec6
https://pubmed.ncbi.nlm.nih.gov/32682944