Zobrazeno 1 - 10
of 81
pro vyhledávání: '"sphingosine kinase inhibitor"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6560 (2024)
Human corneal fibrosis can lead to opacity and ultimately partial or complete vision loss. Currently, corneal transplantation is the only treatment for severe corneal fibrosis and comes with the risk of rejection and donor shortages. Sphingolipids (S
Externí odkaz:
https://doaj.org/article/477bf4d706284777997224728b67bb47
Autor:
Şahin Hande Nur, Adan Aysun
Publikováno v:
Türk Biyokimya Dergisi, Vol 47, Iss 1, Pp 49-58 (2022)
Therapeutic potential of clinically approved FLT3 inhibitor midostaurin has been neglected in wild-type FLT3 positive acute myeloid leukemia (AML). Sphingosine kinase-1 (SK-1) having anti-proliferative functions is studied in various cancers, but not
Externí odkaz:
https://doaj.org/article/8b9a79ef64d34751b4faf2bdf740bd22
Akademický článek
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Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The bioactive sphingolipids ceramide and sphingosine-1-phosphate (S1P) are involved in the regulation of cell homeostasis and activity ranging from apoptosis to proliferation. We recently described that the two compounds ceranib-2 (inhibiting acid ce
Externí odkaz:
https://doaj.org/article/cd81f96d936b4ed9b372bb104e17b31d
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Sphingosine kinases (SPHKs) are conserved lipid enzymes that catalyze the formation of sphingosine-1-phosphate (S1P) through ATP-dependent phosphorylation of sphingosine. Two distinct SPHK isoforms, namely SPHK1 and SPHK2, have been identified to dat
Externí odkaz:
https://doaj.org/article/b512e9fc0b7346868f266b6c6bee4419
Autor:
Li, Hao
Sphingosine kinase 1 (SphK1) is the key enzyme catalyzing the formation of sphingosine-1-phosphate (S1P), which is an important signaling molecule that regulates multiple biological process including inflammatory responses. Elevated SphK1 activity as
Externí odkaz:
http://hdl.handle.net/10919/100741
Autor:
Anika Grafen, Fabian Schumacher, Janice Chithelen, Burkhard Kleuser, Niklas Beyersdorf, Jürgen Schneider-Schaulies
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
As structural membrane components and signaling effector molecules sphingolipids influence a plethora of host cell functions, and by doing so also the replication of viruses. Investigating the effects of various inhibitors of sphingolipid metabolism
Externí odkaz:
https://doaj.org/article/f5824eac03244173a5f912e481e69a69
Autor:
Hande Nur Şahin, Aysun Adan
Publikováno v:
Turkish Journal of Biochemistry. 47:49-58
Objectives Therapeutic potential of clinically approved FLT3 inhibitor midostaurin has been neglected in wild-type FLT3 positive acute myeloid leukemia (AML). Sphingosine kinase-1 (SK-1) having anti-proliferative functions is studied in various cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac19a08b1ecf699e7fa997c535773d0
https://doi.org/10.1515/tjb-2021-0152
https://doi.org/10.1515/tjb-2021-0152
Akademický článek
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Autor:
Geethani Bandara, Rosa Muñoz-Cano, Araceli Tobío, Yuzhi Yin, Hirsh D. Komarow, Avanti Desai, Dean D. Metcalfe, Ana Olivera
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Mastocytosis is a disorder resulting from an abnormal mast cell (MC) accumulation in tissues that is often associated with the D816V mutation in KIT, the tyrosine kinase receptor for stem cell factor. Therapies available to treat aggressive presentat
Externí odkaz:
https://doaj.org/article/b443207c72454c45a2ee98268ff3d370