Zobrazeno 1 - 10
of 2 157
pro vyhledávání: '"sphingosine kinase 1"'
Autor:
So Yeon Lee, Jin Seo Park, Daehwan Kim, Wonseok Jeong, Chenghwan Hwang, Hye One Kim, Chun Wook Park, Bo Young Chung
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 9, Pp 2591-2605 (2024)
Abstract Introduction Patients with atopic dermatitis (AD) have impaired barrier function, which decreases skin hydration, weakens their defense against microorganisms, and culminates in increased inflammatory responses. Here, we conducted a clinical
Externí odkaz:
https://doaj.org/article/ba4e5d6cab4f426d88564b7868fc8e4b
Autor:
Ruiyun Li, Cassandra Cairns, Ting‐Xi Yu, Rao Jaladanki, Claire M. Dodson, Hee Kyoung Chung, Lan Xiao, Jian‐Ying Wang, Douglas J. Turner
Publikováno v:
Physiological Reports, Vol 12, Iss 17, Pp n/a-n/a (2024)
Abstract Many pathological conditions lead to defects in intestinal epithelial integrity and loss of barrier function; Sphingosine‐1‐phosphate (S1P) has been shown to augment intestinal barrier integrity, though the exact mechanisms are not compl
Externí odkaz:
https://doaj.org/article/d2a7c7dec11d45b19ad6606fe0b03eae
Autor:
Wei Huang, MM, Xi Chen, MM, Zizhen Liu, MM, Changwu Li, MD, Xin Wei, MD, Jiabin Zhan, MD, Quan Qiu, MM, Jing Zheng, MD
Publikováno v:
World Allergy Organization Journal, Vol 17, Iss 9, Pp 100963- (2024)
Background: Allergic rhinitis (AR) is a global health issue affecting millions of individuals worldwide. Pyroptosis has emerged as a major player in the development of AR, and targeting its inhibition with specific drugs holds promise for AR treatmen
Externí odkaz:
https://doaj.org/article/7b368af8698b4a3bb097d8e32d974c67
Autor:
Ilma Shakeel, Shaista Haider, Shama Khan, Shahbaz Ahmed, Afzal Hussain, Mohamed F. Alajmi, Anindita Chakrabarty, Mohammad Afzal, Md. Imtaiyaz Hassan
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117123- (2024)
Sphingosine-1-phosphate (S1P) formed via catalytic actions of sphingosine kinase 1 (SphK1) behaves as a pro-survival substance and activates downstream target molecules associated with various pathologies, including initiation, inflammation, and prog
Externí odkaz:
https://doaj.org/article/2be9d4e62f344a0b839c55bdb1ea9d3d
Publikováno v:
Molecules, Vol 29, Iss 19, p 4711 (2024)
In this study, four previously undescribed flavonoids, named epimesatines P (1), Q (2), R (3), and S (4), were isolated from the aerial parts of Epimedium sagittatum Maxim. Their structures and absolute configurations were confirmed via spectroscopic
Externí odkaz:
https://doaj.org/article/9984194b6812454c8379a4105f6f837b
Autor:
Nicolas Coant, Karima Rendja, Lara Bellini, Mélissa Flamment, Jeannine Lherminier, Bernard Portha, Patrice Codogno, Hervé Le Stunff
Publikováno v:
Cells, Vol 13, Iss 7, p 636 (2024)
Insulin-producing pancreatic β cells play a crucial role in the regulation of glucose homeostasis, and their failure is a key event for diabetes development. Prolonged exposure to palmitate in the presence of elevated glucose levels, termed gluco-li
Externí odkaz:
https://doaj.org/article/dd74973ef90a4c938908408f8bef3b7b
Publikováno v:
Experimental Hematology & Oncology, Vol 11, Iss 1, Pp 1-6 (2022)
Abstract Unlike many solid tumors, epithelial ovarian cancer (EOC) has a clear metastatic predilection to the adipocyte-rich niche, especially the omentum. However, the underlying mechanism driving this process remains incomplete. Here we show that S
Externí odkaz:
https://doaj.org/article/4afac96bcb364788b34ada6cdc555f18
Autor:
Thao M. Nguyen, Paul Joyce, David M. Ross, Kristen Bremmell, Manasi Jambhrunkar, Sook S. Wong, Clive A. Prestidge
Publikováno v:
Pharmaceutics, Vol 16, Iss 2, p 209 (2024)
MP-A08 is a novel sphingosine kinase 1 (SPHK1) inhibitor with activity against acute myeloid leukemia (AML). A rationally designed liposome-based encapsulation and delivery system has been shown to overcome the physicochemical challenges of MP-A08 an
Externí odkaz:
https://doaj.org/article/755cd84cdc034bce8bff0cbcf3abbb9e
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