Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes

Autor: Ji-Na Kong, Zhihui Zhu, Yutaka Itokazu, Guanghu Wang, Michael B. Dinkins, Liansheng Zhong, Hsuan-Pei Lin, Ahmed Elsherbini, Silvia Leanhart, Xue Jiang, Haiyan Qin, Wenbo Zhi, Stefka D. Spassieva, Erhard Bieberich

Publikováno v: Journal of Lipid Research, Vol 59, Iss 3, Pp 488-506 (2018)

We reported that amyloid β peptide (Aβ42) activated neutral SMase 2 (nSMase2), thereby increasing the concentration of the sphingolipid ceramide in astrocytes. Here, we show that Aβ42 induced mitochondrial fragmentation in wild-type astrocytes, bu

Externí odkaz: https://doaj.org/article/2e953d848a4e4bdf95da608fbf87f121

Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes.

Autor: Kong JN; Department of Neuroscience and Regenerative Medicine Augusta University, Augusta, GA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA., Zhu Z; Department of Neuroscience and Regenerative Medicine Augusta University, Augusta, GA.; Department of Physiology, University of Kentucky, Lexington, KY., Itokazu Y; Department of Neuroscience and Regenerative Medicine Augusta University, Augusta, GA., Wang G; Department of Neuroscience and Regenerative Medicine Augusta University, Augusta, GA.; Department of Physiology, University of Kentucky, Lexington, KY., Dinkins MB; Department of Neuroscience and Regenerative Medicine Augusta University, Augusta, GA., Zhong L; Department of Neuroscience and Regenerative Medicine Augusta University, Augusta, GA.; Department of Physiology, University of Kentucky, Lexington, KY.; College of Basic Medicine, China Medical University, Shenyang, People's Republic of China., Lin HP; Department of Neuroscience and Regenerative Medicine Augusta University, Augusta, GA.; Department of Physiology, University of Kentucky, Lexington, KY., Elsherbini A; Department of Neuroscience and Regenerative Medicine Augusta University, Augusta, GA.; Department of Physiology, University of Kentucky, Lexington, KY., Leanhart S; Department of Neuroscience and Regenerative Medicine Augusta University, Augusta, GA., Jiang X; Department of Physiology, University of Kentucky, Lexington, KY.; Rehabilitation Center, ShengJing Hospital of China Medical University, Shenyang, People's Republic of China., Qin H; Department of Physiology, University of Kentucky, Lexington, KY., Zhi W; Center of Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA., Spassieva SD; Department of Physiology, University of Kentucky, Lexington, KY erhard.bieberich@uky.edu stefanka.spassieva@uky.edu., Bieberich E; Department of Neuroscience and Regenerative Medicine Augusta University, Augusta, GA erhard.bieberich@uky.edu stefanka.spassieva@uky.edu.; Department of Physiology, University of Kentucky, Lexington, KY.

Publikováno v: Journal of lipid research [J Lipid Res] 2018 Mar; Vol. 59 (3), pp. 488-506. Date of Electronic Publication: 2018 Jan 10.