Clinical Sphingolipids Pathway in Parkinson’s Disease: From GCase to Integrated-Biomarker Discovery

Autor: Ali Esfandiary, David Isaac Finkelstein, Nicolas Hans Voelcker, David Rudd

Publikováno v: Cells, Vol 11, Iss 8, p 1353 (2022)

Alterations in the sphingolipid metabolism of Parkinson’s Disease (PD) could be a potential diagnostic feature. Only around 10–15% of PD cases can be diagnosed through genetic alterations, while the remaining population, idiopathic PD (iPD), mani

Externí odkaz: https://doaj.org/article/700fe8edf4f3407ebcc8346d7a6553ee

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Differential Expression of the Sphingolipid Pathway Is Associated with Sensitivity to the PP2A Activator FTY720 in Colorectal Cancer Cell Lines

Autor: Peter Sciberras, Laura Grech, Godfrey Grech

Publikováno v: Journal of Clinical Medicine
Journal of Clinical Medicine, Vol 10, Iss 4999, p 4999 (2021)
Volume 10
Issue 21

Protein phosphatase 2A (PP2A) is a ubiquitously expressed intracellular serine/threonine phosphatase. Deregulation of PP2A is a common event associated with adenocarcinomas of the colon and rectum. We have previously shown that breast cancer cell lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99173d31634d6fbb66f2c5cbd4028504
http://europepmc.org/articles/PMC8584763

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

4-Hydroxynonenal Contributes to Angiogenesis through a Redox-Dependent Sphingolipid Pathway: Prevention by Hydralazine Derivatives

Autor: Anne Nègre-Salvayre, Mélanie Pucelle, Caroline Camaré, Corinne Bernis, Corinne Vanucci-Bacqué, Robert Salvayre, Michel Baltas, Nathalie Augé, Florence Bedos-Belval, Audrey Swiader

Publikováno v: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, 2017, 2017-04-05, pp.1-11. ⟨10.1155/2017/9172741⟩
Oxidative Medicine and Cellular Longevity, Hindawi, 2017, 2017, pp.1-11. ⟨10.1155/2017/9172741⟩
Oxidative Medicine and Cellular Longevity, Hindawi, 2017, 2017-04-05, pp.1-11. ⟨10.1155/2017/9172741⟩
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)

The neovascularization of atherosclerotic lesions is involved in plaque development and may contribute to intraplaque hemorrhage and plaque fragilization and rupture. Among the various proangiogenic agents involved in the neovascularization process,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aedc859cb8f46765211660675678bb5
https://hal.science/hal-02060417/document