Zobrazeno 1 - 10
of 501
pro vyhledávání: '"spatial profiling"'
Autor:
Seung J. Kim, Matthew J. Cecchini, Elissa Woo, Nathashi Jayawardena, Daniel T. Passos, Frederick A. Dick, Marco Mura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Fibrosing interstitial lung diseases (ILDs) encompass a diverse range of scarring disorders that lead to progressive lung failure. Previous gene expression profiling studies focused on idiopathic pulmonary fibrosis (IPF) and bulk tissue samp
Externí odkaz:
https://doaj.org/article/826d764040fa44a7b05c82414f916d94
Autor:
William P. Duggan, Batuhan Kisakol, Ina Woods, Mohammedreza Azimi, Heiko Dussmann, Joanna Fay, Tony O’Grady, Barry Maguire, Ian S. Reynolds, Manuela Salvucci, Daniel J. Slade, Deborah A. McNamara, John P. Burke, Jochen H.M. Prehn
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTMucinous colorectal cancer (CRC) is a common histological subtype of colorectal adenocarcinoma, associated with a poor response to chemoradiotherapy. The commensal facultative anaerobes fusobacteria, have been associated with poor prognosis s
Externí odkaz:
https://doaj.org/article/2b11e6dc763e4a1aacdfb8cd8e2a82f3
Autor:
Manon A Simard, Carlos Cabrera-Galvez, Santiago Viteri, Felix Geist, Nadine Reischmann, Michael Zühlsdorf, Niki Karachaliou
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101063- (2024)
MET inhibitors have demonstrated efficacy in treating patients with non-small cell lung cancer (NSCLC) harboring METex14 skipping alterations. Advancements in spatial profiling technologies have unveiled the complex dynamics of the tumor microenviron
Externí odkaz:
https://doaj.org/article/3bf51d62f03b48e4a51b131b02e0e59d
Autor:
Maria Danielsen, Thomas Emmanuel, Morten Muhlig Nielsen, Lise Maria Lindahl, Maria Gluud, Niels Ødum, Line Raaby, Torben Steiniche, Lars Iversen, Rikke Bech, Terkild Brink Buus, Claus Johansen
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionThe majority of patients with mycosis fungoides (MF) have an indolent disease course, but a substantial fraction (20-30%) of patients progress to advanced stages – usually with a grave prognosis. Early differentiation between indolent a
Externí odkaz:
https://doaj.org/article/032ca7a08f2441cebfb7829eb806389e
Autor:
Victoria Bingham, Louise Harewood, Stephen McQuaid, Stephanie G. Craig, Julia F. Revolta, Chang S. Kim, Shambhavi Srivastava, Javier Quezada-Marín, Matthew P. Humphries, Manuel Salto-Tellez
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human malignancies. Tissue microarrays (TMA) are an established method of high throughput biomarker interrogation in tissues but may not capture histological features of
Externí odkaz:
https://doaj.org/article/d25a41f56be2446d9bbeea882fd613c5
Autor:
Mark B. Wiley, Jessica Bauer, Valentina Alvarez, Kunaal Mehrotra, Wenxuan Cheng, Zoe Kolics, Michael Giarrizzo, Komala Ingle, Agnieszka B. Bialkowska, Barbara Jung
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Acute Pancreatitis (AP) is associated with high mortality and current treatment options are limited to supportive care. We found that blockade of activin A (activin) in mice improves outcomes in two murine models of AP. To test the hypothesi
Externí odkaz:
https://doaj.org/article/a7d303b3264a468a9a6c0e386cd0a69d
Autor:
Tim Bathe, Gabriela P. Hery, Jonathan A. B. Villareal, Jennifer L. Phillips, Eric M. Cohen, Rohan V. Sharma, Wangchen Tsering, Stefan Prokop
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-25 (2024)
Abstract The disease-specific accumulation of pathological proteins has long been the major focus of research in neurodegenerative diseases (ND), including Alzheimer’s disease (AD) and related dementias (RD), but the recent identification of a mult
Externí odkaz:
https://doaj.org/article/12cef3313feb4dd79e438d8394192c0c
Autor:
Christina Cho, Nazgol-Sadat Haddadi, Michal Kidacki, Gavitt A. Woodard, Saeed Shakiba, Ümmügülsüm Yıldız-Altay, Jillian M. Richmond, Matthew D. Vesely
Publikováno v:
JID Innovations, Vol 5, Iss 1, Pp 100317- (2025)
The spatial organization of the skin is critical for its function. In particular, the skin immune microenvironment is arranged spatially and temporally, such that imbalances in the immune milieu are indicative of disease. Spatial transcriptomic platf
Externí odkaz:
https://doaj.org/article/276c70eb015546d98c8b60972919b5c6
Autor:
Jill M. Brooks, Yuanning Zheng, Kelly Hunter, Benjamin E. Willcox, Janet Dunn, Paul Nankivell, Olivier Gevaert, Hisham Mehanna
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundThe incidence of oropharyngeal cancer (OPC) is increasing, due mainly to a rise in Human Papilloma Virus (HPV)-mediated disease. HPV-mediated OPC has significantly better prognosis compared with HPV-negative OPC, stimulating interest in tre
Externí odkaz:
https://doaj.org/article/f12a3ff832bb48f7a7eb35b9911523e9
Autor:
S. Böning, F. Schneider, A.-K. Huber, D. Langhoff, H. Lin, A. Kaczorowski, A. Stenzinger, M. Hohenfellner, S. Duensing, A. Duensing
Publikováno v:
Immuno-Oncology and Technology, Vol 23, Iss , Pp 100727- (2024)
Background: Spatial biology is an emerging concept to interrogate tumor heterogeneity. The NanoString GeoMx® Digital Spatial Profiling (DSP) platform has become increasingly available. It combines high-plex analysis of protein or messenger RNA expre
Externí odkaz:
https://doaj.org/article/ed80adec76e24926bc48da86a8414767