Zobrazeno 1 - 10
of 182
pro vyhledávání: '"somatic copy-number alterations"'
Autor:
Héctor Herrera-Orozco, Verónica García-Castillo, Eduardo López-Urrutia, Antonio Daniel Martinez-Gutierrez, Eloy Pérez-Yepez, Oliver Millán-Catalán, David Cantú de León, César López-Camarillo, Nadia J. Jacobo-Herrera, Mauricio Rodríguez-Dorantes, Rosalío Ramos-Payán, Carlos Pérez-Plasencia
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 12, Pp 9549-9565 (2023)
Colorectal cancer (CRC) represents the second deadliest malignancy worldwide. Around 75% of CRC patients exhibit high levels of chromosome instability that result in the accumulation of somatic copy number alterations. These alterations are associate
Externí odkaz:
https://doaj.org/article/b1802939daaf41058e4b16337465248c
Autor:
A. W. Adamson, Y. C. Ding, L. Steele, L. A. Leong, R. Morgan, M. T. Wakabayashi, E. S. Han, T. H. Dellinger, P. S. Lin, A. A. Hakim, S. Wilczynski, C. D. Warden, S. Tao, V. Bedell, M. C. Cristea, S. L. Neuhausen
Publikováno v:
Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-14 (2023)
Abstract Background High-grade serous ovarian cancers (HGSCs) display a high degree of complex genetic alterations. In this study, we identified germline and somatic genetic alterations in HGSC and their association with relapse-free and overall surv
Externí odkaz:
https://doaj.org/article/a554d21176a142ac99996e2e44216fb8
Autor:
Abdel Jelil Njouendou, Tibor Szarvas, Arnol Auvaker Zebaze Tiofack, Rovaldo Nguims Kenfack, Pamela Derliche Tonouo, Sidonie Noa Ananga, Esther H. M. Dina Bell, Gustave Simo, Jörg D. Hoheisel, Jens T. Siveke, Smiths S. Lueong
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-12 (2023)
Abstract Background Inflammation is undoubtedly a hallmark of cancer development. Its maintenance within tumors and the consequences on disease aggressiveness are insufficiently understood. Methods Data of 27 tumor entities (about 5000 samples) were
Externí odkaz:
https://doaj.org/article/c4c04dc7508e4c02a1013c66e211ba35
Autor:
Yilin Shi, Huangxuan Shen
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Stomach Adenocarcinoma (STAD) is a leading cause of death worldwide. Somatic Copy Number Alterations (SCNAs), which result in Homologous recombination (HR) deficiency in double-strand break repair, are associated with the progression of STAD. However
Externí odkaz:
https://doaj.org/article/a8beed9c58cf4ee09bf0577befddf06a
Autor:
Tom L. Kaufmann, Marina Petkovic, Thomas B. K. Watkins, Emma C. Colliver, Sofya Laskina, Nisha Thapa, Darlan C. Minussi, Nicholas Navin, Charles Swanton, Peter Van Loo, Kerstin Haase, Maxime Tarabichi, Roland F. Schwarz
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-27 (2022)
Abstract Aneuploidy, chromosomal instability, somatic copy-number alterations, and whole-genome doubling (WGD) play key roles in cancer evolution and provide information for the complex task of phylogenetic inference. We present MEDICC2, a method for
Externí odkaz:
https://doaj.org/article/e4b330fa56874857bbfdc7ede9300d31
Autor:
Ariane Hallermayr, Tobias Wohlfrom, Verena Steinke-Lange, Anna Benet-Pagès, Florentine Scharf, Ellen Heitzer, Ulrich Mansmann, Christopher Haberl, Maike de Wit, Holger Vogelsang, Markus Rentsch, Elke Holinski-Feder, Julia M. A. Pickl
Publikováno v:
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-14 (2022)
Abstract Background Analysis of circulating free DNA (cfDNA) is a promising tool for personalized management of colorectal cancer (CRC) patients. Untargeted cfDNA analysis using whole-genome sequencing (WGS) does not need a priori knowledge of the pa
Externí odkaz:
https://doaj.org/article/0efaedafd6e94b90ae2a7a9642900c92
Autor:
Sam Abujudeh, Sebastian S. Zeki, Meta C.J. van Lanschot, Mark Pusung, Jamie M.J. Weaver, Xiaodun Li, Ayesha Noorani, Andrew J. Metz, Jan Bornschein, Lawrence Bower, Ahmad Miremadi, Rebecca C. Fitzgerald, Edward R. Morrissey, Andy G. Lynch
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract Background Somatic copy number alterations (SCNAs) are an important class of genomic alteration in cancer. They are frequently observed in cancer samples, with studies showing that, on average, SCNAs affect 34% of a cancer cell’s genome. F
Externí odkaz:
https://doaj.org/article/38f12a4dfbc9486895c28a273fc43df1
Akademický článek
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Autor:
Michael J. Schmidt, Rishvanth K. Prabakar, Sarah Pike, Venkata Yellapantula, Chen-Ching Peng, Peter Kuhn, James Hicks, Liya Xu, Jesse L. Berry
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8606 (2023)
Retinoblastoma (RB) is a childhood cancer that forms in the developing retina of young children; this tumor cannot be biopsied due to the risk of provoking extraocular tumor spread, which dramatically alters the treatment and survival of the patient.
Externí odkaz:
https://doaj.org/article/50404d55aee540d4bd16cfbabf63a319
Autor:
Xingyu Chen, Hua Lan, Dong He, Runshi Xu, Yao Zhang, Yaxin Cheng, Haotian Chen, Songshu Xiao, Ke Cao
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundOvarian cancer (OC) has the highest mortality rate among gynecologic malignancy. Hypoxia is a driver of the malignant progression in OC, which results in poor prognosis. We herein aimed to develop a validated model that was based on the hyp
Externí odkaz:
https://doaj.org/article/876af34ad8c54056992c226c4f37e2a0