Zobrazeno 1 - 10
of 3 614
pro vyhledávání: '"soluble guanylate cyclase"'
Autor:
Xin Chen, Yingquan Xiong, Shufei Zeng, Denis Delić, Mohamed Gaballa, Philipp Kalk, Thomas Klein, Bernhard K. Krämer, Berthold Hocher
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionSoluble guanylate cyclase (sGC) stimulators and activators are known to enhance kidney function in various models of chronic kidney disease (CKD) by increasing cyclic guanosine monophosphate (cGMP). Their differential effects on CKD progr
Externí odkaz:
https://doaj.org/article/3b8e296a1fa746699279d3c9445dec30
Autor:
Shuang Yang, Yixiu Zhao, Xiaoling Cheng, Tingting Zhan, Jiaying Tian, Xue Liu, Chunyue Ma, Zhiqi Wang, Luying Jin, Qian Liu, Yanli Wang, Jian Huang, Jinhui Wang, Yan Zhang, Baofeng Yang
Publikováno v:
Engineering, Vol 38, Iss , Pp 133-143 (2024)
Myocardial ischemia is a serious threat to human health, and vascular dysfunction is its main cause. Buxu Tongyu (BXTY) Granule is an effective traditional Chinese medicine (TCM) for treating myocardial ischemia. However, the underlying mechanism of
Externí odkaz:
https://doaj.org/article/0b6e3c3950af4019abfcaed7596f9268
Autor:
Bajwa EK, Cislak D, Kumar A, Li D, Messina EJ, Reynders T, Denef JF, Corcea V, Buch KP, Lai E, Stoch SA
Publikováno v:
International Journal of COPD, Vol Volume 19, Pp 1105-1121 (2024)
Ednan K Bajwa,1 Dawn Cislak,1 Amit Kumar,1 Dan Li,1 Eric J Messina,1 Tom Reynders,2 Jean-François Denef,2 Vasile Corcea,3 Ketan P Buch,4 Eseng Lai,1 S Aubrey Stoch1 1MRL, Merck & Co., Inc., Rahway, NJ, USA; 2Translational Medicine, MSD Belgium, Brus
Externí odkaz:
https://doaj.org/article/7886eda8508e426b928876250387faa7
Autor:
Yiyang Che, Yuuki Shimizu, Takumi Hayashi, Junya Suzuki, Zhongyue Pu, Kazuhito Tsuzuki, Shingo Narita, Rei Shibata, Toyoaki Murohara
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Emerging evidence has documented that circadian rhythm disorders could be related to cardiovascular diseases. However, there is limited knowledge on the direct adverse effects of circadian misalignment on the heart. This study aimed to inves
Externí odkaz:
https://doaj.org/article/646568b0c51049c59c4c0b342e84faae
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Soluble guanylate cyclase (sGC) modulation has been scrutinized in several disease states including heart failure (HF). Recently, it was shown that an sGC modulator improved HF-related hospitalization significantly, though, there was no bene
Externí odkaz:
https://doaj.org/article/2bb695d5841040b18a827b9fa6068d98
Autor:
Yu-zhou Gui, Wei Wang, Qing-qing Wu, Qi-chen Ding, Hong-jie Qian, Qiu-bei Lu, Ying-jun Zhang, Yu-lei Zhuang, Li Deng, Ying-lin Zuo, Lin Luo, Jing-ying Jia
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Heart failure is the most costly cardiovascular disorder. New treatments are urgently needed. This study aims to evaluate the safety, pharmacokinetics, and pharmacodynamic profile of HEC95468, a soluble guanylate cyclase (sGC) stimulator, in healthy
Externí odkaz:
https://doaj.org/article/471eb2450690481191e91200a2f0c4db
Autor:
Mohamed T. Abuelazm, Abdelrahman Attia, Mohamed Abdelnabi, Uzair Jafar, Omar Almaadawy, Mohamed A. Elzeftawy, Abdelrahman Mahmoud, Khaled Albakri, Basel Abdelazeem
Publikováno v:
The Egyptian Heart Journal, Vol 76, Iss 1, Pp 1-14 (2024)
Abstract Background Soluble guanylate cyclase (sGC) stimulators have been investigated for heart failure (HF) in several randomized controlled trials (RCTs). However, its place in the management guidelines of either HFrEF or HfpEF is still inconclusi
Externí odkaz:
https://doaj.org/article/7b91382894ce43b2877eb91aa1437323
Autor:
Qinan Yin, Xingyue Zheng, Yujie Song, Liuyun Wu, Lian Li, Rongsheng Tong, Lizhu Han, Yuan Bian
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Soluble guanylate cyclase agonists and guanylate cyclase C agonists are two popular drugs for diseases of the cardiovascular system and digestive systems. The common denominator in these conditions is the potential therapeutic target of guanylate cyc
Externí odkaz:
https://doaj.org/article/84e645a69eac4d22b972d8b00f5e9689
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Autor:
Frances Varian, Jennifer Dick, Christian Battersby, Stefan Roman, Jenna Ablott, Lisa Watson, Sarah Binmahfooz, Hamza Zafar, Gerry Colgan, John Cannon, Jay Suntharalingam, Jim Lordan, Luke Howard, Colm McCabe, John Wort, Laura Price, Colin Church, Neil Hamilton, Iain Armstrong, Abdul Hameed, Judith Hurdman, Charlie Elliot, Robin Condliffe, Martin Wilkins, Alastair Webb, David Adlam, Ray L. Benza, Kazem Rahimi, Mohadeseh Shojaei‐Shahrokhabadi, Nan X. Lin, James M. S. Wason, Alasdair McIntosh, Alex McConnachie, Jennifer T. Middleton, Roger Thompson, David G. Kiely, Mark Toshner, Alexander Rothman
Publikováno v:
Pulmonary Circulation, Vol 14, Iss 1, Pp n/a-n/a (2024)
Abstract Approved therapies for the treatment of patients with pulmonary arterial hypertension (PAH) mediate pulmonary vascular vasodilatation by targeting distinct biological pathways. International guidelines recommend that patients with an inadequ
Externí odkaz:
https://doaj.org/article/c52635068f23481e953b6d13c82baf53