Zobrazeno 1 - 10
of 281
pro vyhledávání: '"soluble PD-L1"'
Autor:
Margarita Zvirble, Zilvinas Survila, Paulius Bosas, Neringa Dobrovolskiene, Agata Mlynska, Gintaras Zaleskis, Jurgita Jursenaite, Dainius Characiejus, Vita Pasukoniene
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
PurposeThe aim of this study was to assess the role of sPD-L1 and sPD-1 as potential biomarkers in prostate cancer (PCa). The association of the values of these soluble proteins were correlated to the clinical data: stage of disease, Gleason score, b
Externí odkaz:
https://doaj.org/article/a2bc41903f2d4f8b8d23db8de4ac5a45
Autor:
Takeru Kashiwada, Ryotaro Takano, Fumihiko Ando, Shoko Kuroda, Yoshishige Miyabe, Ryuji Owada, Akihiko Miyanaga, Tomoko Asatsuma-Okumura, Masaaki Hashiguchi, Yoshikazu Kanazawa, Hiroshi Yoshida, Masahiro Seike, Akihiko Gemma, Yoshiko Iwai
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: Immune checkpoint inhibitors (ICIs) can induce immune-related adverse events (irAEs). Liquid biomarkers to predict irAE occurrence are urgently needed. We previously developed an ELISA system to specifically detect soluble PD-L1 (sPD-L1)
Externí odkaz:
https://doaj.org/article/9f25c0d48b8e40b28822e0ee50aa0364
Autor:
Fumihiko Ando, Takeru Kashiwada, Shoko Kuroda, Takenori Fujii, Ryotaro Takano, Yoshishige Miyabe, Shinobu Kunugi, Takashi Sakatani, Akihiko Miyanaga, Tomoko Asatsuma-Okumura, Masaaki Hashiguchi, Yoshikazu Kanazawa, Ryuji Ohashi, Hiroshi Yoshida, Masahiro Seike, Akihiko Gemma, Yoshiko Iwai
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
BackgroundThe tumor microenvironment (TME) impacts the therapeutic efficacy of immune checkpoint inhibitors (ICIs). No liquid biomarkers are available to evaluate TME heterogeneity. Here, we investigated the clinical significance of PD-1-binding solu
Externí odkaz:
https://doaj.org/article/7a6226e84bee43938e923417f736a470
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Takashi Kurosaki, Kenji Chamoto, Shinichiro Suzuki, Hiroaki Kanemura, Seiichiro Mitani, Kaoru Tanaka, Hisato Kawakami, Yo Kishimoto, Yasuharu Haku, Katsuhiro Ito, Toshiyuki Sato, Chihiro Suminaka, Mami Yamaki, Yasutaka Chiba, Tomonori Yaguchi, Koichi Omori, Takashi Kobayashi, Kazuhiko Nakagawa, Tasuku Honjo, Hidetoshi Hayashi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe clinical relevance of soluble forms of programmed cell death-1 (sPD-1) and programmed cell death-ligand 1 (sPD-L1) remains unclear. We here investigated the relation between the efficacy of PD-1 blockade and pretreatment plasma levels
Externí odkaz:
https://doaj.org/article/ca0552f7ccdf42e3ad9e80f1d87a4c8b
Autor:
Takashi Shimizu, Eisuke Inoue, Ryotaro Ohkuma, Shinichi Kobayashi, Takuya Tsunoda, Satoshi Wada
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/1afbfe292d48439c963acc6084437cfe
Autor:
Junko Tanizaki, MD, PhD, Hiroaki Kuroda, MD, PhD, Toshihide Yokoyama, MD, Makoto Takahama, MD, PhD, Hiroyasu Shoda, MD, PhD, Atsushi Nakamura, MD, PhD, Yoshitaka Kitamura, MD, PhD, Nobuaki Mamesaya, MD, PhD, Yoshihisa Kadota, MD, PhD, Kenji Sawa, MD, PhD, Kyoichi Okishio, MD, PhD, Morihito Okada, MD, PhD, Chihiro Suminaka, MS, Kenta Noda, PhD, Kazuko Sakai, PhD, Yasutaka Chiba, PhD, Kazuto Nishio, MD, PhD, Kenji Chamoto, PhD, Tasuku Honjo, MD, PhD, Nobuyuki Yamamoto, MD, PhD, Kazuhiko Nakagawa, MD, PhD, Hidetoshi Hayashi, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 4, Iss 12, Pp 100590- (2023)
Introduction: Perioperative treatment in NSCLC has gained marked attention with the introduction of immune checkpoint inhibitors. Such a paradigm shift has given us additional opportunities to evaluate potential biomarkers in patients with these cura
Externí odkaz:
https://doaj.org/article/3f386ee3f72d427a96a00d99cb19bacc
Autor:
Takashi Shimizu, Eisuke Inoue, Ryotaro Ohkuma, Shinichi Kobayashi, Takuya Tsunoda, Satoshi Wada
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionCurrently, first-line immune checkpoint inhibitors (ICIs), including programmed cell death protein-1 (PD-1) inhibitors, are utilized as monotherapy in advanced non-small cell lung cancer (NSCLC) patients with high programmed death ligand-
Externí odkaz:
https://doaj.org/article/79df360ee61b4247bc78ebaffe4da883