Zobrazeno 1 - 10
of 3 274
pro vyhledávání: '"solid phase peptide synthesis"'
Autor:
Giovanni Vivenzio, Maria Carmina Scala, Giulia Auriemma, Carla Sardo, Pietro Campiglia, Marina Sala
Publikováno v:
Green Chemistry Letters and Reviews, Vol 17, Iss 1 (2024)
Solid Phase Peptide Synthesis (SPPS) is the preferred technique for synthesizing bioactive peptides. However, traditional SPPS generates significant waste and employs hazardous solvents like DMF and DCM. The aim of this research is to investigate sol
Externí odkaz:
https://doaj.org/article/b215698705f24df3805aec89eb1865af
Autor:
Hlobisile Nzama, Srinivas Rao Manne, Oleg Marder, Gyorgy Orosz, Beatriz G. de la Torre, Fernando Albericio
Publikováno v:
Green Chemistry Letters and Reviews, Vol 17, Iss 1 (2024)
Although N-ethyl-N’-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC.HCl) is a common reagent in peptide synthesis, it presents two drawbacks. First of all, it is in a tautomerism equilibrium with cyclic form that it is not productive. Secon
Externí odkaz:
https://doaj.org/article/adbd819b867e4545bd2fff0c77dbc9ea
Autor:
Dilyana Dimitrova, Veronica Nemska, Tsvetelina Foteva, Ivan Iliev, Nelly Georgieva, Dancho Danalev
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 716 (2024)
(1) Background: Antimicrobial resistance is growing at an extreme pace and has proven to be an urgent topic, for research into alternative treatments. Such a prospective possibility is hidden in antimicrobial peptides because of their low to no toxic
Externí odkaz:
https://doaj.org/article/e1bd56d786014457bbb4a744f631b3c0
Autor:
Rotimi Sheyi, Jessica T. Mhlongo, Marta Jorba, Ester Fusté, Anamika Sharma, Miguel Viñas, Fernando Albericio, Paula Espinal, Beatriz G. de la Torre
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5883 (2024)
Peptides displaying antimicrobial properties are being regarded as useful tools to evade and combat antimicrobial resistance, a major public health challenge. Here we have addressed dendrimers, attractive molecules in pharmaceutical innovation and de
Externí odkaz:
https://doaj.org/article/03233f01dea746bda4d70872499956c3
Publikováno v:
Results in Chemistry, Vol 6, Iss , Pp 101076- (2023)
A method for the introduction of bifunctionalized 1,4,7,10-tetraazacyclododecane-N,N’,N’’,N’’’-tetraacetic acid (DOTA) into the bridging unit of peptide-based radiopharmaceuticals has been developed. The method is executed in the context
Externí odkaz:
https://doaj.org/article/14bbec5ebe624e79b8bdbc8d04dc33b5
Autor:
Bo Ma, Jinyuan Gong, Xin Li, Wenqiang Liu, Baoquan Chen, Zijian Lai, Shiying Shang, Yaohao Li, Jian Yin, Zhongping Tan
Publikováno v:
Results in Chemistry, Vol 6, Iss , Pp 101017- (2023)
Chemical synthesis has become an increasing popular approach for the production of proteins because of its flexibility and convenience in changing protein sequence and/or structure. However, at present, the efficiency of protein chemical synthesis is
Externí odkaz:
https://doaj.org/article/6d9e73af45ca47a6ad5037be19e87099
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 17, Pp 1247-1274 (2023)
Sebastian Vaas,1 Markus O Zimmermann,1 Theresa Klett,1 Frank M Boeckler1,2 1Department of Pharmacy and Biochemistry, Eberhard Karls Universität Tübingen, Laboratory for Molecular Design and Pharmaceutical Biophysics, Institute of Pharmaceutical Sci
Externí odkaz:
https://doaj.org/article/482bcab4572a4d03ae3cdcd2f5006481
Publikováno v:
SLAS Technology, Vol 28, Iss 2, Pp 89-97 (2023)
The development of peptide-based pharmaceutics is a hot topic in the pharmaceutical industry and in basic research. However, from the research and development perspective there is an unmet need for new, alternative, solid-phase peptide synthesizers t
Externí odkaz:
https://doaj.org/article/2e9a9c1ea30747f2ae680cf7ccb4efeb
Autor:
George Barany, Paul R. Hansen
Publikováno v:
Molecules, Vol 29, Iss 6, p 1317 (2024)
The international peptide community rejoiced when one of its most distinguished members, Morten Meldal of Denmark, shared the 2022 Nobel Prize in Chemistry. In fact, the regiospecific solid-phase “copper(I)-catalyzed 1,3-dipolar cycloaddition of te
Externí odkaz:
https://doaj.org/article/929aa013337348aaa41cc00649ec3e76
Autor:
Sinazo Z.Z. Cobongela, Maya M. Makatini, Zikhona Njengele-Tetyana, Lucky M. Sikhwivhilu, Nicole R.S. Sibuyi
Publikováno v:
Arabian Journal of Chemistry, Vol 16, Iss 8, Pp 105000- (2023)
Acyldepsipeptides (ADEPs) are receiving more attention as prospective antimicrobial agents due to their unique mode of action and chemical properties. However, their therapeutic potential is limited by their poor pharmacokinetic properties. Chemical
Externí odkaz:
https://doaj.org/article/1537182a5ba14c83a1de6a96a5718598