Zobrazeno 1 - 10
of 1 429
pro vyhledávání: '"snca"'
Autor:
Maryam Rahimi-Balaei, Shayan Amiri, Thomas Lamonerie, Sih-Rong Wu, Huda Y Zoghbi, G Giacomo Consalez, Daniel Goldowitz, Hassan Marzban
Publikováno v:
eLife, Vol 13 (2024)
Cerebellar nuclei (CN) neurons serve as the primary output of the cerebellum and originate from the cerebellar primordium at early stages of cerebellar development. These neurons are diverse, integrating information from the cerebellar cortex and rel
Externí odkaz:
https://doaj.org/article/40048ecde0f747bb80269e69c46618f1
Autor:
Yoshitsugu Nakamura, Shigeki Arawaka
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
Autophagy has two distinct pathways, degradation and secretion. Autophagic degradation plays a pivotal role in cellular homeostasis by the formation of a double-membrane autophagosome in concert with numerous ATG (autophagy-related) proteins. However
Externí odkaz:
https://doaj.org/article/4e6589f1b9e9440fa4b9128f97fd14b3
Autor:
Oluwadamilola Omolara Ojo, Osigwe P Agabi, Ismail O Ishola, Olajumoke O Oshinaike, Sani A Abubakar, Kolawole W Wahab, Abiodun H Bello, Rufus O Akinyemi, Uduak Williams, Simon I Ozomma, Oluchi Ekenze, Emmanuel Iwuozo, Yakub W Nyandaiti, Francis I Ojini, Henry Houlden, John Hardy, Njideka Ulunma Okubadejo
Publikováno v:
Journal of Clinical Sciences, Vol 21, Iss 2, Pp 49-56 (2024)
Introduction: The risk of developing neurodegenerative disorders (NDDs) such as Alzheimer’s disease and related dementias (ADRD) and Parkinson’s disease and atypical parkinsonism (PDAP), has been alluded to arise predominantly from the interplay
Externí odkaz:
https://doaj.org/article/e50659148c2f4a579fe1553de93c0093
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background Alpha synuclein (α-synuclein) is coded by SNCA gene and found in a helical form with phospholipids or in an unfolded arrangement in the cytosol and belongs to the synuclein family other than beta synuclein and gamma synuclein. It
Externí odkaz:
https://doaj.org/article/a7cd51fc5179448fb546bdd262cd7788
Publikováno v:
Neurología (English Edition), Vol 39, Iss 4, Pp 321-328 (2024)
Introduction: The aim of this study was to compare the effect of five types of PEGlated nanoliposomes (PNLs) on α-synuclein (α-syn) fibrillization, attenuation of microglial activation, and silence of the SNCA gene, which encodes α-syn. Methods: T
Externí odkaz:
https://doaj.org/article/ef6e3b391760404891bc11e6e11c528f
Autor:
Chie Kudo-Saito, Hiroshi Imazeki, Hiroki Ozawa, Hirofumi Kawakubo, Hidekazu Hirano, Narikazu Boku, Ken Kato, Hirokazu Shoji
Publikováno v:
Translational Oncology, Vol 48, Iss , Pp 102075- (2024)
Peritoneal tumor dissemination and subsequent malignant tumor ascites (MTA) occur unexpectedly and repeatedly in patients with gastrointestinal (GI) cancers, and worsen quality of life and prognosis of the patients. Various treatments have been clini
Externí odkaz:
https://doaj.org/article/9a1d813fda324317aa1ac7ae97784b95
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background and aimPathological changes in the central nervous system (CNS) begin before the clinical symptoms of Alzheimer’s Disease (AD) manifest, with the hippocampus being one of the first affected structures. Current treatments fail to alter AD
Externí odkaz:
https://doaj.org/article/4faab178320d40a68716fd3c2013495d
Autor:
Tomoya Kon, Shelley L. Forrest, Seojin Lee, Jun Li, Helen Chasiotis, Nasna Nassir, Mohammed J. Uddin, Anthony E. Lang, Gabor G. Kovacs
Publikováno v:
Neurobiology of Disease, Vol 198, Iss , Pp 106551- (2024)
Multiple system atrophy (MSA) is characterized by glial cytoplasmic inclusions (GCIs) containing aggregated α-synuclein (α-syn) in oligodendrocytes. The origin of α-syn accumulation in GCIs is unclear, in particular whether abnormal α-syn aggrega
Externí odkaz:
https://doaj.org/article/9f8e98dda3ed4320bd4654f1648f7e33
Autor:
Hidefumi Suzuki, Naohiro Egawa, Keiko Imamura, Takayuki Kondo, Takako Enami, Kayoko Tsukita, Mika Suga, Yuichiro Yada, Ran Shibukawa, Ryosuke Takahashi, Haruhisa Inoue
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-14 (2024)
Abstract Synucleinopathies refer to a group of disorders characterized by SNCA/α-synuclein (α-Syn)-containing cytoplasmic inclusions and neuronal cell loss in the nervous system including the cortex, a common feature being cognitive impairment. Sti
Externí odkaz:
https://doaj.org/article/e2c171af79924b389b070d5267a36739
Publikováno v:
Frontiers in Cognition, Vol 3 (2024)
Parkinson's disease (PD) is a complex disorder that is influenced by multiple genetic risk factors. There is a significant heterogeneity in PD presentation, both pathologically and clinically. Some of the most common and important symptoms affecting
Externí odkaz:
https://doaj.org/article/0b562b92ba0f4019966b2fc57472c186