RNA editing enzyme ADAR1 governs the circadian expression of P-glycoprotein in human renal cells by regulating alternative splicing of the ABCB1 gene

Autor: Yuji Omata, Satoru Koyanagi, Tomoaki Yamauchi, Shigehiro Ohdo, Naoya Matsunaga, Akito Tsuruta

Publikováno v: The Journal of Biological Chemistry

The expression and function of some xenobiotic transporters vary according to the time of the day, causing the dosing time-dependent changes in drug disposition and toxicity. P-glycoprotein (P-gp), encoded by the ABCB1 gene, is highly expressed in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96ad8969573203451720bdd4279545d
https://doi.org/10.1016/j.jbc.2021.100601

Crystal structure and functional characterization of the human RBM25 PWI domain and its flanking basic region

Autor: Zhenhua Shao, Fan Yang, Jihui Wu, Fudong Li, Dandan Qian, Minhao Wu, Yunyu Shi, Deshun Gong, Mian Wu

Publikováno v: Biochemical Journal

Human RBM25 (RNA-binding motif protein 25) is a novel splicing factor that contains a PWI domain, a newly identified RNA/DNA-binding domain, and regulates Bcl-x pre-mRNA alternative splicing. The flanking basic region has been suggested to serve as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bc44ab74a1b2d42f5b0272b60bf061
https://doi.org/10.1042/bj20121382

Cap-binding complex (CBC)

Autor: Thomas, Gonatopoulos-Pournatzis, Victoria H, Cowling

Publikováno v: Biochemical Journal

The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene expression. Protein complexes recruited to 7mG mediate key processing events throughout the lifetime of the transcript. One of the most important mediators of 7mG functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::85f784ec3298f3bf10931336bc5f877e
https://pubmed.ncbi.nlm.nih.gov/24354960

Functional roles of protein splicing factors

Autor: Hsin Chou Chen, Soo-Chen Cheng

Publikováno v: Bioscience Reports, Vol 32, Iss 4 (2012)
Bioscience Reports

RNA splicing is one of the fundamental processes in gene expression in eukaryotes. Splicing of pre-mRNA is catalysed by a large ribonucleoprotein complex called the spliceosome, which consists of five small nuclear RNAs and numerous protein factors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b583fc6165c9ed19c932a620e21c5068
http://www.bioscirep.org/bsr/032/0345/bsr0320345.htm

Genome-wide analysis of KAP1, the 7SK snRNP complex, and RNA polymerase II.

Autor: McNamara RP; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Guzman C; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Reeder JE; The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., D'Orso I; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Publikováno v: Genomics data [Genom Data] 2016 Feb 04; Vol. 7, pp. 250-5. Date of Electronic Publication: 2016 Feb 04 (Print Publication: 2016).