Zobrazeno 1 - 10
of 385
pro vyhledávání: '"snRNA-seq"'
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract Chronic methamphetamine (METH) use, a prevalent psychostimulant, is known to impair attention, yet the cellular mechanisms driving these deficits remain poorly understood. Here, we employed a rat model of repeated passive METH injections and
Externí odkaz:
https://doaj.org/article/b3edd3bde2e5486ab1a73ce9b083ff85
Publikováno v:
Neuroscience Research, Vol 207, Iss , Pp 13-25 (2024)
Sleep is homeostatically regulated by sleep pressure, which increases during wakefulness and dissipates during sleep. Recent studies have suggested that the cerebral neocortex, a six-layered structure composed of various layer- and projection-specifi
Externí odkaz:
https://doaj.org/article/b0caeb827af847be9a5ad0cbbd67d60a
Autor:
Mohammad Dehestani, Velina Kozareva, Cornelis Blauwendraat, Ernest Fraenkel, Thomas Gasser, Vikas Bansal
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-10 (2024)
Abstract Several prior studies have proposed the involvement of various brain regions and cell types in Parkinson’s disease (PD) pathology. Here, we performed snRNA-seq on the prefrontal cortex and anterior cingulate regions from a small cohort of
Externí odkaz:
https://doaj.org/article/eed45c239e5848d1b734879955c3654e
Autor:
Lanlan Yi, Qiuyan Li, Junhong Zhu, Wenjie Cheng, Yuxiao Xie, Ying Huang, Hongye Zhao, Meilin Hao, Hongjiang Wei, Sumei Zhao
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-17 (2024)
Abstract Background Global per capita meat consumption continues to rise, especially pork. Meat quality is influenced by the content of intramuscular fat (IMF) as a key factor. The longissimus dorsi muscle of Dahe pigs (DHM, IMF: 7.98% ± 1.96%) and
Externí odkaz:
https://doaj.org/article/db762904771f4c168e638e64d5fe8fd8
Autor:
Peidong Zhang, Zhe Wang, Yuling Yang, Songqi Duan, Shengqian Dou, Huiying Sun, Chi Zhang, Xueying Li, Jinpeng Li, Yakun Liu, Mengmeng Sang, Xueqi Lv, Tianli Zhang, Chunxiao Chen, Fengcongzhe Gong, Xiaorui Ping, Wenlu Xing, Wenhao Ju, Yi Ping, Baofa Sun
Publikováno v:
MedComm – Future Medicine, Vol 3, Iss 3, Pp n/a-n/a (2024)
Abstract Coronavirus disease 2019 (COVID‐19) pandemic has caused millions of deaths. The risk of COVID‐19 spreading still exists after the deconfinement act, Omicron became the dominant variant. Although N6‐methyladenosine (m6A) regulators has
Externí odkaz:
https://doaj.org/article/c6812b689d4d434b82bd6cfc68e3ad57
Autor:
Andrew S. Perry, Kaushik Amancherla, Xiaoning Huang, Michelle L. Lance, Eric Farber-Eger, Priya Gajjar, Junedh Amrute, Lindsey Stolze, Shilin Zhao, Quanhu Sheng, Cassandra M. Joynes, Zhongsheng Peng, Toshiko Tanaka, Stavros G. Drakos, Kory J. Lavine, Craig Selzman, Joseph R. Visker, Thirupura S. Shankar, Luigi Ferrucci, Saumya Das, Jane Wilcox, Ravi B. Patel, Ravi Kalhan, Sanjiv J. Shah, Keenan A. Walker, Quinn Wells, Nathan Tucker, Matthew Nayor, Ravi V. Shah, Sadiya S. Khan
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101704- (2024)
Summary: Given expanding studies in epidemiology and disease-oriented human studies offering hundreds of associations between the human “ome” and disease, prioritizing molecules relevant to disease mechanisms among this growing breadth is importa
Externí odkaz:
https://doaj.org/article/50bde58bdf8445a68ec76dff9c7c6f72
Publikováno v:
Experimental Biology and Medicine, Vol 249 (2024)
Aldehyde dehydrogenase 1, family member A2, is a retinoic acid-synthesizing enzyme encoded by Aldh1a2 in mice and ALDH1A2 in humans. This enzyme is indispensable for kidney development, but its role in kidney physiology and pathophysiology remains to
Externí odkaz:
https://doaj.org/article/2ceb0cffc8fa43e3ab00cd04e3648d55
Autor:
Wenxi Yu, Sophie F. Hill, Limei Zhu, Yiannos Demetriou, Faith Reger, Joanna Mattis, Miriam H. Meisler
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106591- (2024)
Gain-of-function mutations in SCN8A cause developmental and epileptic encephalopathy (DEE), a disorder characterized by early-onset refractory seizures, deficits in motor and intellectual functions, and increased risk of sudden unexpected death in ep
Externí odkaz:
https://doaj.org/article/189c97fcbc4d4863b31a95564c0f9ff5
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
IntroductionProgrammed cell death (PCD) is a fundamental biological process crucial for plant development. Despite recent advancements in our understanding of PCD’s molecular mechanisms, the intricate orchestration of this process within plant cell
Externí odkaz:
https://doaj.org/article/124f05417fdc4f45a9da8c28d87cfb4f
Autor:
Hao Wang, Kai He, Huan Zhang, Quanyong Zhang, Lei Cao, Jing Li, Zhaoshan Zhong, Hao Chen, Li Zhou, Chao Lian, Minxiao Wang, Kai Chen, Pei-Yuan Qian, Chaolun Li
Publikováno v:
eLife, Vol 12 (2024)
Bathymodioline mussels dominate deep-sea methane seep and hydrothermal vent habitats and obtain nutrients and energy primarily through chemosynthetic endosymbiotic bacteria in the bacteriocytes of their gill. However, the molecular mechanisms that or
Externí odkaz:
https://doaj.org/article/b8da85189a9b4da783fdadd08e1a6246