Postzygotic mosaicism of SMARCB1 variants in patients with rhabdoid tumors: A not-so-rare condition exposing to successive tumors.

Autor: Thomson G; INSERM U830, Laboratory of Translational Research in Pediatric Oncology, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France., Filser M; Somatic Genetic Unit, Department of Pathology and Diagnostic and Theranostic Medecine, PSL Research University, Institut Curie Hospital, Paris, France., Guerrini-Rousseau L; Department of Pediatric and Adolescent Oncology, Paris-Saclay University, Gustave Roussy Cancer Campus & INSERM U981, Molecular Predictors and New Targets in Oncology, Paris-Saclay University, Gustave Roussy, Villejuif, France., Tauziede-Espariat A; Department of Neuropathology, GHU Paris-Psychiatry and Neurosciences, Sainte-Anne Hospital & UMR S1266, IMA-BRAIN, Paris Psychiatry and Neurosciences Institute (IPNP)/INSERM, Paris, France., Bourneix C; Somatic Genetic Unit, Department of Pathology and Diagnostic and Theranostic Medecine, PSL Research University, Institut Curie Hospital, Paris, France., Gauthier-Villars M; Department of Genetics, PSL Research University, Institut Curie, Paris, France., Simaga F; Department of Genetics, PSL Research University, Institut Curie, Paris, France., Beccaria K; Department of Neurosurgery, Paris-Cité University, Necker Sick Children's University Hospital, Paris, France., Faure-Conter C; Pediatric Hematology and Oncology Institute, Lyon, France., Maureille A; Department of Medical Oncology, Léon Bérard Cancer Center, Lyon, France., Zattara-Cannoni H; Department of Genetics, La Timone Children's Hospital, Marseille, France., Andre N; Department of Pediatric Hematology, Immunology and Oncology, La Timone Children's Hospital & CRCM-INSERM U1068, REMAP-4Kids, Aix Marseille University, Marseille, France., Entz-Werle N; Pediatric Onco-Hematology Unit, Strasbourg University Hospital, Strasbourg, France., Brugieres L; Department of Pediatric and Adolescent Oncology, Paris-Saclay University, Gustave Roussy Cancer Campus & INSERM U981, Molecular Predictors and New Targets in Oncology, Paris-Saclay University, Gustave Roussy, Villejuif, France., Mansuy L; Department of Pediatric Hematology and Oncology, Nancy University Hospital, Vandœuvre-lès-Nancy, France., Denizeau P; Department of Genetics, Rennes University Hospital, Rennes, France., Julia S; Department of Medical Genetics, Toulouse Purpan University Hospital, Toulouse, France., Ingster O; Department of Medical Genetics, Angers University Hospital, Angers, France., Lejeune S; Department of Genetics, Lille University Hospital, Lille, France., Brahimi A; Department of Genetics, Lille University Hospital, Lille, France., Coupier I; Department of Pathology and Oncobiology, Montpellier University Hospital, Montpellier, France., Bonadona V; Department of Public Health Prevention, Centre Léon Bérard, Lyon, France., Delattre O; INSERM U830, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France., Masliah-Planchon J; Somatic Genetic Unit, Department of Pathology and Diagnostic and Theranostic Medecine, PSL Research University, Institut Curie Hospital, Paris, France., Bourdeaut F; INSERM U830, Laboratory of Translational Research in Pediatric Oncology, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France.; SIREDO Pediatric Oncology Department, SIREDO Pediatric Oncology Center, Institut Curie & INSERM U830, Laboratory of Translational Research in Pediatric Oncology, Institut Curie, Paris-Cité University, Paris, France.

Publikováno v: Neuro-oncology [Neuro Oncol] 2024 Nov 04; Vol. 26 (11), pp. 2102-2112.

Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways.

Autor: Feng S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. shengrui.feng@uhn.ca.; The First Affiliated Hospital of University of South China, Hengyang, Hunan, China. shengrui.feng@uhn.ca., Marhon SA; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Sokolowski DJ; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada., D'Costa A; Department of Computer Science, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., Soares F; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Mehdipour P; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ishak C; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Loo Yau H; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Ettayebi I; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Patel PS; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Chen R; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Liu J; The Cardiac Development and Early Intervention Unit, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, China., Zuzarte PC; Ontario Institute for Cancer Research, Toronto, ON, Canada., Ho KC; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada., Ho B; Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Ning S; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Huang A; The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON, Canada.; Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Arrowsmith CH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada., Wilson MD; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada., Simpson JT; Department of Computer Science, University of Toronto, Toronto, ON, Canada.; Ontario Institute for Cancer Research, Toronto, ON, Canada., De Carvalho DD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. daniel.decarvalho@uhnresearch.ca.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. daniel.decarvalho@uhnresearch.ca.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 29; Vol. 15 (1), pp. 9321. Date of Electronic Publication: 2024 Oct 29.

Lack of SMARCB1 expression characterizes a subset of human and murine peripheral T-cell lymphomas.

Autor: Fischer A; Institute of Human Genetics, Ulm University Medical Center, Ulm, Germany., Albert TK; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Moreno N; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Interlandi M; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany.; Institute of Medical Informatics, University of Münster, 48149, Münster, Germany., Mormann J; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Glaser S; Institute of Human Genetics, Ulm University Medical Center, Ulm, Germany., Patil P; Institute of Human Genetics, Ulm University Medical Center, Ulm, Germany., de Faria FW; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Richter M; Institute for Experimental Pathology, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany., Verma A; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Balbach ST; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Wagener R; Institute of Human Genetics, Ulm University Medical Center, Ulm, Germany., Bens S; Institute of Human Genetics, Ulm University Medical Center, Ulm, Germany., Dahlum S; Institute of Human Genetics, Ulm University Medical Center, Ulm, Germany., Göbel C; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg, Eppendorf (UKE), 20251, Hamburg, Germany.; Research Institute Children's Cancer Center, 20251, Hamburg, Germany., Münter D; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Inserte C; Institute of Medical Informatics, University of Münster, 48149, Münster, Germany., Graf M; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Kremer E; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Melcher V; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Di Stefano G; Pathological Anatomy Section, Careggi University Hospital, Florence, Italy., Santi R; Pathological Anatomy Section, Careggi University Hospital, Florence, Italy., Chan A; Department of Pathology, Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York City, NY, USA., Dogan A; Department of Pathology, Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York City, NY, USA., Bush J; Division of Anatomical Pathology, British Columbia Children's Hospital and Women's Hospital and Health Center, Vancouver, BC, Canada., Hasselblatt M; Institute of Neuropathology, University Hospital Münster, 48149, Münster, Germany., Cheng S; Division of Pediatric Hematology/Oncology/BMT, Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada., Spetalen S; Department of Pathology, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Fosså A; Department of Oncology, Oslo University Hospital-Norwegian Radium Hospital, Oslo, Norway., Hartmann W; Division of Translational Pathology, Gerhard-Domagk-Institut für Pathologie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, Gebäude D17, 48149, Münster, Germany., Herbrüggen H; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Robert S; Department of Medicine A, Hematology, Oncology, and Pneumology, University Hospital Münster, Münster, Germany., Oyen F; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg, Eppendorf (UKE), 20251, Hamburg, Germany., Dugas M; Institute of Medical Informatics, University of Münster, 48149, Münster, Germany.; Institute of Medical Informatics, Heidelberg University Hospital, Heidelberg, Germany., Walter C; Institute of Medical Informatics, University of Münster, 48149, Münster, Germany., Sandmann S; Institute of Medical Informatics, University of Münster, 48149, Münster, Germany., Varghese J; Institute of Medical Informatics, University of Münster, 48149, Münster, Germany., Rossig C; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Schüller U; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg, Eppendorf (UKE), 20251, Hamburg, Germany.; Research Institute Children's Cancer Center, 20251, Hamburg, Germany.; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), 20251, Hamburg, Germany., Tzankov A; Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Pedersen MB; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark., d'Amore FA; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Mellgren K; Department of Pediatric Oncology and Hematology, Sahlgrenska University Hospital, The Queen Silvia Children's Hospital, Gothenburg, Sweden., Kontny U; Section of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Department of Pediatric and Adolescent Medicine, RWTH Aachen University Hospital, Aachen, Germany., Kancherla V; Institute of Pathology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital, Lausanne, Switzerland., Veloza L; Institute of Pathology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital, Lausanne, Switzerland., Missiaglia E; Institute of Pathology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital, Lausanne, Switzerland., Fataccioli V; INSERM U955, Université Paris-Est, Créteil, France.; Département de Pathologie, Hôpitaux Universitaires Henri Mondor, AP-HP, INSERM U955, Université Paris Est Créteil, Créteil, France., Gaulard P; Département de Pathologie, Hôpitaux Universitaires Henri Mondor, AP-HP, INSERM U955, Université Paris Est Créteil, Créteil, France., Burkhardt B; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany., Soehnlein O; Institute for Experimental Pathology, Center for Molecular Biology of Inflammation, University of Münster, Münster, Germany., Klapper W; Department of Pathology, Haematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Kiel, Germany., de Leval L; Institute of Pathology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital, Lausanne, Switzerland., Siebert R; Institute of Human Genetics, Ulm University Medical Center, Ulm, Germany., Kerl K; Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, Münster, Germany. Kornelius.kerl@ukmuenster.de.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 03; Vol. 15 (1), pp. 8571. Date of Electronic Publication: 2024 Oct 03.

Expression profiling of circulating lncRNA GIAT4RA, lncRNA AATBC, lncRNA Sirt1-AS, and SMARCB1 in lung cancer patients.

Autor: Hussein NA; Applied Medical Chemistry Department, Medical Research Institute, Alexandria University, Alexandria, Egypt. neveen.hussien@alexu.edu.eg., Ebied SA; Applied Medical Chemistry Department, Medical Research Institute, Alexandria University, Alexandria, Egypt., Belal AAM; Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Ahmad MA; Clinical Pathology Department, Military Medical Academy, Cairo, Egypt., Weheida ESA; Applied Medical Chemistry Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.

Publikováno v: BMC cancer [BMC Cancer] 2024 Sep 23; Vol. 24 (1), pp. 1175. Date of Electronic Publication: 2024 Sep 23.

SMARCB1 (INI1) Deficient Tumours of the Uterine Cervix: Report of Two Cases, Including One Associated With an NTRK Fusion.

Autor: Razack R, Butt JL, Hostein I, Velasco V, Croce S, Olory C, Fu L, Foulkes WD, McCluggage WG

Publikováno v: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists [Int J Gynecol Pathol] 2024 Sep 01; Vol. 43 (5), pp. 464-471. Date of Electronic Publication: 2024 Jan 22.