Zobrazeno 1 - 10
of 727
pro vyhledávání: '"small molecule drugs"'
Publikováno v:
Zhongguo quanke yixue, Vol 27, Iss 17, Pp 2155-2166 (2024)
Background Ulcerative colitis (UC) is a persistent immune-mediated inflammatory bowel disease characterized by chronic relapses and remissions. The management of UC remains a subject of contention, particularly as approximately half of the patients e
Externí odkaz:
https://doaj.org/article/a80c85abcb824c36854714a9d5d7d3b5
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Lichen amyloidosis (LA) is a predominant type of primary cutaneous amyloidosis that is characterized by persistent and intense skin itching. Although multiple therapeutics strategies are available for its treatment, there is no standard treatment so
Externí odkaz:
https://doaj.org/article/a39988e5dad1439d8e4c5faaa268b92c
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117343- (2024)
Background and aims: Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world and the sixth leading cause of cancer death worldwide, and it is urgent to find safe and effective drugs for treatment. As an important therapeuti
Externí odkaz:
https://doaj.org/article/5801b9efd2f54922b462b8d29bae1a04
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 178, Iss , Pp 117179- (2024)
Diabetes, a metabolic disease caused by abnormally high levels of blood glucose, has a high prevalence rate worldwide and causes a series of complications, including coronary heart disease, stroke, peripheral vascular disease, end-stage renal disease
Externí odkaz:
https://doaj.org/article/1218c7ce7bcd4136a0ec5f6fae92596a
Publikováno v:
Cancer Biology & Medicine, Vol 21, Iss 5, Pp 382-399 (2024)
Immune checkpoint inhibitors (ICIs) are used to relieve and refuel anti-tumor immunity by blocking the interaction, transcription, and translation of co-inhibitory immune checkpoints or degrading co-inhibitory immune checkpoints. Thousands of small m
Externí odkaz:
https://doaj.org/article/aa781a13d9664f5395153c422423ff77
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-13 (2024)
Abstract Background Targeted small-molecule drugs in the treatment of systemic lupus erythematosus (SLE) have attracted increasing attention from clinical investigators. However, there is still a lack of evidence on the difference in the efficacy and
Externí odkaz:
https://doaj.org/article/d9881ed3a8494fff83fa42d4224f31b7
Publikováno v:
Pifu-xingbing zhenliaoxue zazhi, Vol 31, Iss 1, Pp 48-55 (2024)
Patients with atopic dermatitis (AD) have skin barrier dysfunction, which is closely related to keratinocyte (KC) abnormalities. Upon stimulation by external factors, KCs release a large number of inflammatory mediators, thereby activating type 2 inf
Externí odkaz:
https://doaj.org/article/ffc5d2dbbb0f424c8c5b80bc2d32833c
Autor:
Min Feng, Qiang Zhou, Huimin Xie, Chang Liu, Mengru Zheng, Shuyu Zhang, Songlin Zhou, Jian Zhao
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 3, Pp 512-518 (2024)
CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger receptor class B family and regulates the pathological progress of metabolic diseases. CD36 was recently found to be widely expressed in various cell types in the n
Externí odkaz:
https://doaj.org/article/7d97fd8a436048fd9e9707261e178223
Publikováno v:
Regenerative Therapy, Vol 24, Iss , Pp 201-210 (2023)
Background: We mainly studied the mechanism by which phenytoin promotes osteogenic differentiation of human jawbone marrow stem cells. Methods: Bone marrow stem cells were extracted from jaw bone tissue debris obtained from 5 subjects undergoing impl
Externí odkaz:
https://doaj.org/article/88ccc1b1faf441158087b499ae3ce984
Autor:
Ling Zhang, Ziruoyu Wang, Kailu Liu, Yihang Liu, Shuai Wang, Wei Jiang, Fanghui Lu, Yongjun Dang
Publikováno v:
MedComm – Oncology, Vol 3, Iss 1, Pp n/a-n/a (2024)
Abstract The tumor microenvironment (TME) is the ecosystem surrounding a tumor, which usually consists of nontumoral cells or components, and molecules they produce and release. The frequent and continuous interplay between tumor cells and the TME st
Externí odkaz:
https://doaj.org/article/9750f72a005a4ab49228ad4a10738c17