Zobrazeno 1 - 10
of 12 185
pro vyhledávání: '"small hairpin RNA"'
Publikováno v:
Вавиловский журнал генетики и селекции, Vol 22, Iss 4, Pp 425-432 (2018)
Matrix metalloproteinases (MMPs) are important for the pathogenesis of psoriasis and other autoimmune disorders. In the extracellular matrix, accumulation of proinflammatory cytokines, such as interleukin 17A (IL-17A), leads to induction of several M
Externí odkaz:
https://doaj.org/article/6c0f24dbf15f480fb70278dc02cdfc91
Autor:
Jose H Arteaga, Jorma Hinkula, Edvard C.I Smith, Britta Wahren, Abdalla J. Mohamed, Maria E. Cardona, Kristin Gustafsson, Birger Christensson
Publikováno v:
Molecular Biology Reports. 49:11187-11192
Treatment with RNAi against HIV-1 transcripts efficiently inhibits viral replication but induces selection of escape mutants; therefore, the CCR5 coreceptor was suggested as an additional target. Blocking viral and host transcripts improved the antiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe54446ea0ada4efdf481db98f99483
https://doi.org/10.1007/s11033-022-07899-9
https://doi.org/10.1007/s11033-022-07899-9
Publikováno v:
Cancer Biology & Medicine. 19:1211-1223
OBJECTIVE The BRAF inhibitor, vemurafenib, has been widely used in the treatment of patients with melanoma-bearing BRAFV600E mutations. While the initial response to vemurafenib is usually excellent, the majority of patients eventually develop resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54743dc7904c6301fc0b9e8b86e55e2a
https://doi.org/10.20892/j.issn.2095-3941.2020.0294
https://doi.org/10.20892/j.issn.2095-3941.2020.0294
Autor:
Makoto Murakami, Takamitsu Nakamura, Keiji Miyazawa, Yosuke Watanabe, Kiyotaka Kugiyama, Takashi Yokoyama, Daisuke Fujioka
Publikováno v:
Journal of Atherosclerosis and Thrombosis. 29:692-718
Aims It was suggested that group V secretory phospholipase A2 (sPLA2-V) existed in the nucleus. This study examined whether nuclear sPLA2-V plays a role in endocytosis of acetylated low-density lipoprotein (AcLDL) in monocyte/macrophage-like cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e31db9181c882ca28e69e88143955535
https://doi.org/10.5551/jat.62216
https://doi.org/10.5551/jat.62216
Autor:
J. Oborski, Esther Kurth, Earl Mcdonald, Florencia Rago, Audrey Kauffmann, Jessi Ambrose, Zainab Jagani, Kathleen Sprouffske, Lindsey Rodrigues, Peter Aspesi, Julie T. Chen, Felipa A. Mapa, Tinya Abrams, Hyo-eun C. Bhang, David A. Ruddy, GiNell Elliott, M. Bonney
Publikováno v:
Molecular Cancer Research. 20:361-372
Various subunits of mammalian SWI/SNF chromatin remodeling complexes display loss-of-function mutations characteristic of tumor suppressors in different cancers, but an additional role for SWI/SNF supporting cell survival in distinct cancer contexts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564b0c6a1b6102d0b6097a4f720fe7fb
https://doi.org/10.1158/1541-7786.mcr-21-0390
https://doi.org/10.1158/1541-7786.mcr-21-0390
Collagen XII Regulates Corneal Stromal Structure by Modulating Transforming Growth Factor-β Activity
Publikováno v:
Am J Pathol
Collagen XII is a regulator of corneal stroma structure and function. The current study examined the roles of collagen XII in regulating corneal stromal transforming growth factor (TGF)-β activation and latency. Specifically, with the use of convent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a3b805201bcfc712cbe3f1138583db
https://doi.org/10.1016/j.ajpath.2021.10.014
https://doi.org/10.1016/j.ajpath.2021.10.014
Autor:
Hyeong Ji Lee, Oded Singer, Jennifer S. Y. Ma, Seok Jin Kim, Won Seog Kim, Hyung Cheol Kim, Youngil Koh, Chan Hyuk Kim, Inkyung Jung, Cedric Hupperetz, Yujean Lee, Young-Ho Lee, Xinxin Wang, Su Kyung Nam
Publikováno v:
Mol Ther
CD19-targeting chimeric antigen receptor (CAR) T cells have become an important therapeutic option for patients with relapsed and refractory B cell malignancies. However, a significant portion of patients still do not benefit from the therapy owing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d63d9f57550ffbef8bf4a6e01d953c
https://doi.org/10.1016/j.ymthe.2021.10.004
https://doi.org/10.1016/j.ymthe.2021.10.004
Publikováno v:
Immunity, Inflammation and Disease, Vol 10, Iss 2, Pp 143-154 (2022)
Immunity, Inflammation and Disease
Immunity, Inflammation and Disease
Introduction This study investigates the synergistic effect of TGF‐β1 and Nrp‐1 on CD4+CD25+ Tregs' stabilization, and the associated pathways of signal transduction, in vitro models in the presence of LPS. Materials and Methods Spleen CD4+CD25+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba211a61aa24e345bc8eb2b70a668c0
https://doaj.org/article/7eed80bfcf3746c7bdb63c996bc46fff
https://doaj.org/article/7eed80bfcf3746c7bdb63c996bc46fff
Autor:
Nancy D. Ebelt, Edith Zuniga, Monica Marzagalli, Vic Zamloot, Bruce R. Blazar, Ravi Salgia, Edwin R. Manuel
Publikováno v:
Biomedicines, Vol 8, Iss 12, p 617 (2020)
Therapeutic options for non-small cell lung cancer (NSCLC) treatment have changed dramatically in recent years with the advent of novel immunotherapeutic approaches. Among these, immune checkpoint blockade (ICB) using monoclonal antibodies has shown
Externí odkaz:
https://doaj.org/article/e6ed696cdf6246b3a3e188ae25db54a2
Autor:
Atsuro Miyata, Kohei Hashiguchi, Thu Nguyen Thi, Yoshimune Sameshima, Akira Yamashita, Yuki Kambe, Takashi Kurihara
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 108-115 (2022)
Brain glycogen metabolism is known to be involved in the learning and memory processes. Protein targeting to glycogen (PTG) is a crucial molecule for glycogenesis, and its expression level is shown to be increased in the dorsal hippocampus during fea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc14529e11b8863097255b4d97985e3
https://doi.org/10.1016/j.jphs.2021.10.008
https://doi.org/10.1016/j.jphs.2021.10.008