Zobrazeno 1 - 10
of 359
pro vyhledávání: '"slc1a5"'
Autor:
Yingying Zhao, Xueqing Xu, Huaiyang Cai, Wenhong Wu, Yingwei Wang, Cheng Huang, Heping Qin, Shuangyang Mo
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
BackgroundThe etiopathogenesis of hepatic stellate cells (HSC) activation has yet to be completely comprehended, and there has been broad concern about the interplay between amino acid transporter and cell proliferation. This study proposed exploring
Externí odkaz:
https://doaj.org/article/f80a6ac7767c426d80989f82ddbb23af
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Hepatocellular carcinoma (HCC) is a common malignant tumor, and glutamine is vital for tumor cells. The role of glutamine transporter SLC1A5 in tumor progression and transarterial chemoembolization (TACE) efficacy is under study.
Externí odkaz:
https://doaj.org/article/fda1a8b24d754d42a359bc5deab8d901
Publikováno v:
Immunobiology, Vol 229, Iss 5, Pp 152841- (2024)
Hepatocellular carcinoma (HCC) stands as one of the most prevalent malignancies. While PD-1 immune checkpoint inhibitors have demonstrated promising therapeutic efficacy in HCC, not all patients exhibit a favorable response to these treatments. Gluta
Externí odkaz:
https://doaj.org/article/6d6ab460f1b0498d93b52038baad2ff3
Publikováno v:
Translational Neuroscience, Vol 15, Iss 1, Pp 1231-51 (2024)
Silibinin has been found to inhibit glioblastoma (GBM) progression. However, the underlying molecular mechanism by which Silibinin regulates GBM process remains unclear.
Externí odkaz:
https://doaj.org/article/a8e0368a131348b98973733733e0910b
Autor:
Yuanyan Wei, Shuting Geng, Yu Si, Yuerong Yang, Qihang Chen, Sijing Huang, Xiaoning Chen, Wenlong Xu, Yinchao Liu, Jianhai Jiang
Publikováno v:
Advanced Science, Vol 11, Iss 3, Pp n/a-n/a (2024)
Abstract Targeting the niche components surrounding glioblastoma stem cells (GSCs) helps to develop more effective glioblastoma treatments. However, the mechanisms underlying the crosstalk between GSCs and microenvironment remain largely unknown. Cla
Externí odkaz:
https://doaj.org/article/944924e450bf4594b27df1ac6a7a3d52
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-9 (2023)
Abstract Macrophages are important effector cells in tumor progression and immune regulation. Previously, we demonstrated that the transcription suppressor homeobox containing 1(HMBOX1) exhibits immunosuppressive activity in LPS-induced acute liver i
Externí odkaz:
https://doaj.org/article/31477a6f0816428ead7863bbf2610e5a
Autor:
Brent R. Lyda, Gregory P. Leary, Jill Farnsworth, Benjamin Seaver, Derek Silvius, Michael P. Kavanaugh, C. Sean Esslinger, Nicholas R. Natale
Publikováno v:
Molecules, Vol 29, Iss 10, p 2330 (2024)
As a conformationally restricted amino acid, hydroxy-l-proline is a versatile scaffold for the synthesis of diverse multi-functionalized pyrrolidines for probing the ligand binding sites of biological targets. With the goal to develop new inhibitors
Externí odkaz:
https://doaj.org/article/09739a5a115743fe8c51173f32001947
Publikováno v:
World Journal of Surgical Oncology, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background Circular RNA (circRNA) has been proved to be an important molecular target for cancer treatment. However, the function and molecular mechanism of circ_0000808 in non-small cell lung cancer (NSCLC) are still unclear. Methods Quanti
Externí odkaz:
https://doaj.org/article/6490a2fb931c48f7a9c7d075637e137f
Publikováno v:
Cellular & Molecular Biology Letters, Vol 27, Iss 1, Pp 1-14 (2022)
Highlights circ_0025033 knockdown inhibited ovarian cancer malignant behaviors. circ_0025033 served as a hsa_miR-370-3p sponge. hsa_miR-370-3p targeted SLC1A5.
Externí odkaz:
https://doaj.org/article/19e23a113b2d458dbb6877cdf951cf9d
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 262, Iss , Pp 115204- (2023)
Arsenic exposure increases the risk of bladder cancer in humans, but its underlying mechanisms remain elusive. The alanine, serine, cysteine-preferring transporter 2 (ASCT2, SLC1A5) is frequently overexpressed in cancer cells. The aim of this study w
Externí odkaz:
https://doaj.org/article/373efff3f5a24dd6b14c6fa8b67a8538