Zobrazeno 1 - 10
of 833
pro vyhledávání: '"skin fibrosis"'
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-18 (2024)
Abstract Background Epidermal remodeling and hypertrophy are hallmarks of skin fibrotic disorders, and keratinocyte to mesenchymal (EMT)-like transformations drive epidermis alteration in skin fibrosis such as keloids and hypertrophic scars (HTS). Wh
Externí odkaz:
https://doaj.org/article/1cda7b3f62df4e2ca60891c18b038721
Autor:
Xiaojuan Ma, Shuang Zhang, Xiaochen Ren, Yujie Feng, Hui Li, Shi Chen, Jingen Xu, Yanting Wang, Guo-yuan Peng, Qingran Yan, Huifeng Jia, Simin Xia, Xiaopei Cui, Xiaofang Chen, Xianfei Pan, Shaojie Wang, Haijia Yu, Xiaoyue Wei, Mingwei Li, Bei Liu, Jingyue Xu, Qiaoxia Qian, Xiangyang Zhu, Yifan Zhan, Liangjing Lu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Antibody drugs targeting single inflammatory cytokines have revolutionized the treatment of immune-mediated inflammatory diseases. To investigate whether dual targeting interleukin-17 (IL-17) and IL-36 enhances anti-inflammatory activity, bispecific
Externí odkaz:
https://doaj.org/article/e25db7dcba894a3da6c08a51ec9bda6c
Publikováno v:
Pifu-xingbing zhenliaoxue zazhi, Vol 31, Iss 5, Pp 340-346 (2024)
Typical skin fibrotic diseases include hypertrophic scar, keloid and scleroderma. These diseases characterized by excessive activation of myofibroblast, and abnormal deposition of extracellular matrix can lead to permanent scarring and organ dysfunct
Externí odkaz:
https://doaj.org/article/20d151a4d1af4a8b8d6c570516ce20a9
Autor:
Zhiqin Cao, Keke Zhang, Jingruo Liu, Yu Pan, Jiayi Shi, Luxin Li, Xiaocan Sun, Shiqi Li, Xiaohuan Yuan, Dan Wu
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-11 (2024)
Abstract Background Skin fibrosis affects the normal function of the skin. TGF-β1 is a key cytokine that affects organ fibrosis. The latency-associated peptide (LAP) is essential for TGF-β1 activation. We previously constructed and prepared truncat
Externí odkaz:
https://doaj.org/article/53938f1a717f4ade854d139076ae6949
Akademický článek
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Autor:
Grigory Demyashkin, Yelena Shapovalova, Anna Marukyan, Matvey Vadyukhin, Liia Alieva, Nargiz Guseynova, Sergey Koryakin, Marina Filimonova, Petr Shegay, Andrei Kaprin
Publikováno v:
Open Veterinary Journal, Vol 13, Iss 12, Pp 1570-1582 (2023)
Background: Skin cancer is the most frequently diagnosed type of cancer among all malignant neoplasms. The decrease in mitotic activity and the death of intact keratinocytes arise due to the constantly renewing epithelium is highly sensitive to ionis
Externí odkaz:
https://doaj.org/article/60726edcde7848b9aeb6454c2029a890
Autor:
Zirui Zhao, Yanchao Rong, Rong Yin, Ruixi Zeng, Zhongye Xu, Dongming Lv, Zhicheng Hu, Xiaoling Cao, Bing Tang
Publikováno v:
Biomedicines, Vol 12, Iss 10, p 2409 (2024)
Background: Microbiota dysbiosis has been reported to lead to leaky epithelia and trigger numerous dermatological conditions. However, potential causal associations between skin microbiota and skin fibrosis and whether immune cells act as mediators r
Externí odkaz:
https://doaj.org/article/2bc09f6951a0455b978229ce9fd39242
Autor:
Zirui Zhao, Zhongye Xu, Dongming Lv, Yanchao Rong, Zhicheng Hu, Rong Yin, Yunxian Dong, Xiaoling Cao, Bing Tang
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
ObjectiveSkin fibrosis is a lesion in the dermis causing to itching, pain, and psychological stress. The gut microbiome plays as an essential role in skin diseases developments. We conducted a Mendelian randomization study to determine the causal ass
Externí odkaz:
https://doaj.org/article/5c56d3a71e7945c7a690c7e4151f775b
Autor:
Bianca Saveria Fioretto, Irene Rosa, Alessia Tani, Elena Andreucci, Eloisa Romano, Eleonora Sgambati, Mirko Manetti
Publikováno v:
Cells, Vol 13, Iss 12, p 1067 (2024)
Aberrant sialylation with overexpression of the homopolymeric glycan polysialic acid (polySia) was recently reported in fibroblasts from fibrotic skin lesions. Yet, whether such a rise in polySia levels or sialylation in general may be functionally i
Externí odkaz:
https://doaj.org/article/4111a80928604fa7af429bbaefa3247a
Autor:
L. A. Garzanova
Publikováno v:
Научно-практическая ревматология, Vol 61, Iss 4, Pp 466-474 (2023)
Systemic sclerosis (SSc) is one of the most severe systemic rheumatic diseases, characterized by the development of progressive skin fibrosis and damage to internal organs, accompanied by a decrease in the quality of life and high mortality. The trea
Externí odkaz:
https://doaj.org/article/e4ee62965f094ae8a0a77876a1f5848d