Zobrazeno 1 - 10
of 2 696
pro vyhledávání: '"sirt6"'
Autor:
Jingyi Du, Yue Yin, Dong Wu, Can Diao, Tiantian Zhao, Fan Peng, Naigang Li, Dongshuang Wang, Jiaming Shi, Liyan Wang, Liang Kong, Wenjuan Zhou, Aijun Hao
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-21 (2024)
Abstract Demyelination occurs widely in the central nervous system (CNS) neurodegenerative diseases, especially the multiple sclerosis (MS), which with a complex and inflammatory lesion microenvironment inhibiting remyelination. Sirtuin6 (SIRT6), a h
Externí odkaz:
https://doaj.org/article/1c4f60bd008b4ea38486e526657a06ec
Autor:
Yong Du, Jiaqing He, Yanni Xu, Xun Wu, Hongbo Cheng, Jiegang Yu, Xiaoliang Wang, Yaqing An, Yang Wu, Wei Guo
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Vascular dementia (VaD) is a prevalent form of dementia resulting from chronic cerebral hypoperfusion (CCH). However, the pathogenic mechanisms of VaD and corresponding therapeutic strategies are not well understood. Sirtuin 6 (SIRT6) has be
Externí odkaz:
https://doaj.org/article/668a3585517941d481c58d00047cc945
Autor:
Jan Frohlich, Niccolò Liorni, Manuel Mangoni, Gabriela Lochmanová, Pavlína Pírek, Nikola Kaštánková, Pille Pata, Jan Kucera, George N. Chaldakov, Anton B. Tonchev, Illar Pata, Vera Gorbunova, Eric Leire, Zbyněk Zdráhal, Tommaso Mazza, Manlio Vinciguerra
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Obesity is a major health burden. Preadipocytes proliferate and differentiate in mature adipocytes in the adipogenic process, which could be a potential therapeutic approach for obesity. Deficiency of SIRT6, a stress-responsive pr
Externí odkaz:
https://doaj.org/article/2fd96820fdfd4c449cf7c617509a6899
Publikováno v:
Renal Failure, Vol 46, Iss 2 (2024)
Background Podocyte injury plays an important role in the occurrence and progression of diabetic kidney disease (DKD), which leads to albuminuria. Cytoskeletal remodeling is an early manifestation of podocyte injury in DKD. However, the underlying me
Externí odkaz:
https://doaj.org/article/b7622f6a02c54b64add13872901e6320
Publikováno v:
Renal Failure, Vol 46, Iss 2 (2024)
Objective Sirt6, reactive oxygen species and ferroptosis may participate in the pathogenesis of Diabetic Nephropathy (DN). Exploring the relationship between Sirt6, oxidative stress, and ferroptosis provides new scientific ideas to DN.Methods Human p
Externí odkaz:
https://doaj.org/article/b13c5a3dc31648e98d99fd2aeb6abdef
Autor:
Wei Zhang, Lei Bai, Wentao Xu, Jun Liu, Yi Chen, Weiqiang Lin, Huasong Lu, Binwei Wang, Benyan Luo, Guoping Peng, Kejing Zhang, Chengyong Shen
Publikováno v:
Advanced Science, Vol 11, Iss 44, Pp n/a-n/a (2024)
Abstract The degeneration of the neuromuscular junction (NMJ) and the decline in motor function are common features of aging, but the underlying mechanisms have remained largely unclear. This study reveals that Sirt6 is reduced in aged mouse muscles.
Externí odkaz:
https://doaj.org/article/3530161c678d49e9b982fd85c7433652
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 671-682 (2024)
Peripheral nerve injury is a prevalent disease but the spontaneous recovery of nerve function is protracted and incomplete. Given the damaging of stem cells and fragile of intra-neural structures in the course of stem cell transplantation, our study
Externí odkaz:
https://doaj.org/article/da7b2807e70240618717c103f58d9bff
Autor:
Xinyuan Xu, Qian Zhang, Xufeng Wang, Jing Jin, Chengwei Wu, Li Feng, Xiuyan Yang, Mingzhu Zhao, Yingyi Chen, Shaoyong Lu, Zhen Zheng, Xiaobing Lan, Yi Wang, Yan Zheng, Xuefeng Lu, Qiufen Zhang, Jian Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1302-1316 (2024)
Pancreatic cancer, one of the most aggressive malignancies, has no effective treatment due to the lack of targets and drugs related to tumour metastasis. SIRT6 can promote the migration of pancreatic cancer and could be a potential target for antimet
Externí odkaz:
https://doaj.org/article/305cb32e6c0f49d18f0c0ae380b1e656
Autor:
Yu-lin Liu, Jia-yu Liu, Xin-xin Zhu, Jian-hua Wei, Shuang-ling Mi, Su-ya Liu, Xiu-liang Li, Wei-wei Zhang, Ling-li Zhao, Hua Wang, De-xiang Xu, Lan Gao
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 274, Iss , Pp 116191- (2024)
The reproduction toxicity of pubertal exposure to Microcystin-LR (MC-LR) and the underlying mechanism needs to be further investigated. In the current study, pubertal male ICR mice were intraperitoneally injected with 2 μg/kg MC-LR for four weeks. P
Externí odkaz:
https://doaj.org/article/949b3852d6e14ea88ed7e15587aebe1d
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-18 (2023)
Abstract Background Disruption of the BBB is a harmful event after intracranial hemorrhage (ICH), and this disruption contributes to a series of secondary injuries. We hypothesized that FGF21 may have protective effects after intracranial hemorrhage
Externí odkaz:
https://doaj.org/article/791ee2abca3141f9963236450c3d4b77