Zobrazeno 1 - 10
of 42 999
pro vyhledávání: '"sirna"'
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 12369-12387 (2024)
Xiaochen Ma,1 Yubo Cui,2 Min Zhang,1 Qinghua Lyu,2 Jun Zhao2 1The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, People’s Republic of China; 2Department of Ophthalmology, Shenzhen People’s Hospital (The Second Clinical Me
Externí odkaz:
https://doaj.org/article/b1fb2a2f75044c8baaaba052a93f295b
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 11517-11537 (2024)
Bohong Cen,1,2 Jian Zhang,1 Xinghua Pan,3 Zhongyuan Xu,2 Rong Li,1 Chengcong Chen,1 Baiyao Wang,1 Zhiyong Li,4 Guoqian Zhang,1 Aimin Ji,5 Yawei Yuan1 1Department of Radiation Oncology, Guangzhou Institute of Cancer Research, The Affiliated Cancer Hos
Externí odkaz:
https://doaj.org/article/a9a71544756b47fcb5aa218b4c010ab2
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Chronic inflammation and NLRP3 inflammasome activation are among the determining factors of breast malignancies. Paclitaxel (PTX) is a drug used in breast cancer treatment which sustains prolonged inflammation, reducing the effectiveness of
Externí odkaz:
https://doaj.org/article/7cea1cd7940a44d3ad68974f26a90af6
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Integrin α5β1 plays a crucial role in the invasion of nonphagocytic cells by Staphylococcus aureus (S. aureus), thereby facilitating infection development. Lipid nanoparticles (LNPs) serve as an effective vehicle for delivering
Externí odkaz:
https://doaj.org/article/fcf470d92454439c8069091008fa2160
Autor:
Ming Li, Yuanyuan Li, Jun Zheng, Zhen Ma, Jianye Zhang, Hao Wu, Yangyang Zhu, Pan Li, Fang Nie
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-26 (2024)
Abstract The immunosuppressive tumor microenvironment (TME) significantly inhibits the effective anti-tumor immune response, greatly affecting the efficacy of immunotherapy. Most tumor-associated macrophages (TAMs) belong to the M2 phenotype, which c
Externí odkaz:
https://doaj.org/article/94b4a401689348a28447768f5a8172f3
Publikováno v:
Nano Biomedicine and Engineering, Vol 16, Iss 3, Pp 416-428 (2024)
Malignant tumors remain a serious threat to human health and life and are a major public health problem globally. Herein, we designed and synthesized a novel nucleic acid nanomedicine AS1411-siRNA-LNPs (As@LNPs). Bmi-1 siRNA was coated with cationic
Externí odkaz:
https://doaj.org/article/969a76f9b03e4cab8ecb5298f3ea98e3
Autor:
Nan Lu, Qiming Jiang, Tianshu Xu, Qiyuan Gao, Yuepeng Wang, Zixian Huang, Zhiquan Huang, Xiaoding Xu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-15 (2024)
Abstract Background Long noncoding RNAs (lncRNAs) are widely involved in cancer development and progression, but the functions of most lncRNAs have not yet been elucidated. Metastasis is the main factor restricting the therapeutic outcomes of various
Externí odkaz:
https://doaj.org/article/0a11748ea24b45ee8ffd428befa11991
Autor:
M. M. Kaganova, I. P. Shilovskiy, E. D. Timotievich, K. V. Yumashev, D. A. Gurskii, K. V. Vinogradova, M. V. Popova, M. R. Khaitov
Publikováno v:
Медицинская иммунология, Vol 26, Iss 5, Pp 1107-1114 (2024)
Allergic rhinitis (AR) is an inflammatory disease of the upper respiratory tract (nasal mucosa). AR affects up to 40% of the world’s population; in the Russian Federation, the incidence is 18% to 30%, depending on the region. Despite the fact that
Externí odkaz:
https://doaj.org/article/5cf5cec5475f4820943040c215bfd52c
Autor:
Shima Hasani, Mohammad Khalaj-Kondori, Sahar Safaei, Mohammad Amini, Negin Riazi-Tabrizi, Mohadeseh Maghsoudi, Behzad Baradaran
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background Gastric cancer (GC) is a highly chemoresistant malignancy with a poor prognosis. Paclitaxel’s low response rate as second-line chemotherapy for advanced GC has prompted intensive research into its molecular basis and prospective
Externí odkaz:
https://doaj.org/article/ba01d739403343a9ba23d91f293e5ba4
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 3802-3817 (2024)
Small nucleic acid drugs, composed of nucleotides, represent a novel class of pharmaceuticals that differ significantly from conventional small molecule and antibody-based therapeutics. These agents function by selectively targeting specific genes or
Externí odkaz:
https://doaj.org/article/5915be80fbe64a2ebe7f9e79127c8733