Zobrazeno 1 - 10
of 1 287
pro vyhledávání: '"single-cell transcriptome"'
Autor:
Wenbo Chen, Xin Chen, Lei Yao, Jing Feng, Fengyue Li, Yuxin Shan, Linli Ren, Chenjian Zhuo, Mingqian Feng, Shan Zhong, Chunjiang He
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2754-2762 (2024)
Altered cell-cell communication is a hallmark of aging, but its impact on bone marrow aging remains poorly understood. Based on a common and effective pipeline and single-cell transcriptome sequencing, we detected 384,124 interactions including 2575
Externí odkaz:
https://doaj.org/article/0dd08fc61c9a41ae85da6825a9de8fad
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Background Cutaneous malignant melanoma is a very aggressive and metastatic form of skin cancer, typically linked with poor outcomes. Advances in genomic analysis have underscored the crucial role of T cells in tumor immunity. Immune checkpo
Externí odkaz:
https://doaj.org/article/516c48cfffdd43a4843ee3baf6e4e692
Autor:
Xin Wang, Shen Li, Chen Liu, Jiawei Zhao, Gangfeng Ren, Feng Zhang, Xuyang Liu, Shuang Cao, Yuming Xu, Zongping Xia
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background In mouse models of atherosclerosis, knockout of the PLA2G2A gene has been shown to reduce the volume of atherosclerotic plaques. Clinical trials have demonstrated the potential of using the sPLA2 inhibitor Varespladib in combinati
Externí odkaz:
https://doaj.org/article/39e438bfc66047b1a751b7ca8808a0e4
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Background Tumour invading muscle in head and neck squamous cell carcinoma (HNSCC) is often associated with destructive growth and poor prognosis. However, the phenotypic functions and pathological mechanisms of muscle-invasive cancer cells
Externí odkaz:
https://doaj.org/article/99a8b6f073c04c618411952768e71114
Autor:
Dao-Han Zhang, Chen Liang, Shu-Yang Hu, Xiao-Yong Huang, Lei Yu, Xian-Long Meng, Xiao-Jun Guo, Hai-Ying Zeng, Zhen Chen, Lv Zhang, Yan-Zi Pei, Mu Ye, Jia-Bin Cai, Pei-Xin Huang, Ying-Hong Shi, Ai-Wu Ke, Yi Chen, Yuan Ji, Yujiang Geno Shi, Jian Zhou, Jia Fan, Guo-Huan Yang, Qi-Man Sun, Guo-Ming Shi, Jia-Cheng Lu
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Single-cell technology depicts integrated tumor profiles including both tumor cells and tumor microenvironments, which theoretically enables more robust diagnosis than traditional diagnostic standards based on only pathology. However, the in
Externí odkaz:
https://doaj.org/article/e9d2b0231e9149bfa667fd275a856f8c
Publikováno v:
Journal of Inflammation Research, Vol Volume 17, Pp 6203-6227 (2024)
Zhuohua Zhang,1,2 Yan Liu,2 Da Huang,2 Zhaohe Huang1,3,4 1Department of Cardiology, First Affiliated Hospital of Jinan University, Guangzhou, 510630, People’s Republic of China; 2Department of Cardiology, Affiliated Hospital of Youjiang Medical Uni
Externí odkaz:
https://doaj.org/article/97caaac3c53645818fcfbee11b7986a9
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-19 (2024)
Abstract Background The internal heterogeneity of breast cancer, notably the tumor microenvironment (TME) consisting of malignant and non-malignant cells, has been extensively explored in recent years. The cells in this complex cellular ecosystem act
Externí odkaz:
https://doaj.org/article/17c7448b694a4fa5bf6ea6a2e831c042
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract EGFR mutations are critical oncogenic drivers in lung adenocarcinoma (LUAD). However, the mechanisms by which they impact the tumor microenvironment (TME) and tumor immunity are unclear. Furthermore, the reasons underlying the poor response
Externí odkaz:
https://doaj.org/article/cfcd2476c68c427f9f1e93421babaafd
Publikováno v:
Poultry Science, Vol 103, Iss 12, Pp 104433- (2024)
Accompanied by the accelerated growth rate of chickens, the quality of chicken meat has deteriorated in recent years. Wooden breast (WB) is a severe myopathy affecting meat quality, and its pathophysiology depends on gene expression and intercellular
Externí odkaz:
https://doaj.org/article/5652636a3bef4c9e893f6ca1dcf55a4c
Publikováno v:
Poultry Science, Vol 103, Iss 12, Pp 104416- (2024)
Follicle selection, a crucial step in maintaining continuous egg production in chickens, is a process that relies on granulosa cells (GCs). In this study, we aimed to identify the key genes that are involved in follicle selection from our previous si
Externí odkaz:
https://doaj.org/article/ba1d78faf75d493ea235fa53fede70c8