Phenotypically sorted highly and weakly migratory triple negative breast cancer cells exhibit migratory and metastatic commensalism

Autor: Lauren A. Hapach, Wenjun Wang, Samantha C. Schwager, Devika Pokhriyal, Emily D. Fabiano, Cynthia A. Reinhart-King

Publikováno v: Breast Cancer Research, Vol 25, Iss 1, Pp 1-12 (2023)

Abstract Background Intratumor heterogeneity is a well-established hallmark of cancer that impedes cancer research, diagnosis, and treatment. Previously, we phenotypically sorted human breast cancer cells based on migratory potential. When injected i

Externí odkaz: https://doaj.org/article/74f55ca45e284d36a5bce61053d4ab43

A Bidirectional Single‐Cell Migration and Retrieval Chip for Quantitative Study of Dendritic Cell Migration

Autor: Ning Shao, Yufu Zhou, Jun Yao, Pengchao Zhang, Yanni Song, Kai Zhang, Xin Han, Bin Wang, Xuewu Liu

Publikováno v: Advanced Science, Vol 10, Iss 8, Pp n/a-n/a (2023)

Abstract Dendritic cell (DC) migration is a fundamental step during execution of its adaptive immunity functions. Studying DC migration characteristics is critical for development of DC‐dependent allergy treatments, vaccines, and cancer immunothera

Externí odkaz: https://doaj.org/article/7bfc6bc03cb64306899c80d01f7be91e

Single‐Cell Mechanical Characterization of Human Macrophages

Autor: Tom M. J. Evers, Vahid Sheikhhassani, Huaqi Tang, Mariëlle C. Haks, Tom H. M. Ottenhoff, Alireza Mashaghi

Publikováno v: Advanced NanoBiomed Research, Vol 2, Iss 7, Pp n/a-n/a (2022)

Macrophages remodel their mechanics during differentiation toward different subtypes and drastically adapt their shapes during phagocytosis or entry to inflamed tissues. Although these functions depend on cell mechanical properties, the mechanical be

Externí odkaz: https://doaj.org/article/930b88d253634c20b357262eea378044

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Inhibition of Carbonic Anhydrase IX Suppresses Breast Cancer Cell Motility at the Single-Cell Level

Autor: Linas Mazutis, Vilma Petrikaite, Agne Janoniene, Daumantas Matulis

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11571, p 11571 (2021)
International journal of molecular sciences: Special issue "New drugs for breast cancer treatment", Basel : MDPI, 2021, vol. 22, iss. 21, art. no. 11571, p. [1-11]

Protein Carbonic Anhydrase IX (CA IX), which is expressed in various hypoxic solid tumors in order to maintain proper pH, is also related to cancer cell adhesion, invasion, and metastasis processes. Here, we investigated whether CA IX inhibition by a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a0eadfff2a9da7c3e8c0ba549d9efe
http://europepmc.org/articles/PMC8584155