Zobrazeno 1 - 10
of 123
pro vyhledávání: '"single-cell metabolomics"'
Publikováno v:
Zhipu Xuebao, Vol 45, Iss 6, Pp 785-792 (2024)
Breast cancer is a malignant tumor that predominantly affects women. The incidence of breast cancer has risen annually and is increasingly occurring in younger population, posing a significant threat to women’s health. Estrogen receptor-positive br
Externí odkaz:
https://doaj.org/article/70625db52a54491abc3bceffc138a7ed
Autor:
Shanshan Pan, Luan Yin, Jie Liu, Jie Tong, Zichuan Wang, Jiahui Zhao, Xuesong Liu, Yong Chen, Jing Miao, Yuan Zhou, Su Zeng, Tengfei Xu
Publikováno v:
MedComm, Vol 5, Iss 11, Pp n/a-n/a (2024)
Abstract Identification of therapeutic targets can directly elucidate the mechanism and effect of drug therapy, which is a central step in drug development. The disconnect between protein targets and phenotypes under complex mechanisms hampers compre
Externí odkaz:
https://doaj.org/article/118552e1b22746ceb95d94c4c8d0e69b
Autor:
Tianrun Xu, Hang Li, Peng Dou, Yuanyuan Luo, Siming Pu, Hua Mu, Zhihao Zhang, Disheng Feng, Xuesen Hu, Ting Wang, Guang Tan, Chuang Chen, Haiyang Li, Xianzhe Shi, Chunxiu Hu, Guowang Xu
Publikováno v:
Advanced Science, Vol 11, Iss 16, Pp n/a-n/a (2024)
Abstract High‐coverage mass spectrometry analysis of single‐cell metabolomics remains challenging due to the extremely low abundance and wide polarity of metabolites and ultra‐small volume in single cells. Herein, a novel concentric hybrid ioni
Externí odkaz:
https://doaj.org/article/cc77e21d86594b7ab3b56ab3199c2bc7
Akademický článek
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Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
Resistance to drug treatment is a critical barrier in cancer therapy. There is an unmet need to explore cancer hallmarks that can be targeted to overcome this resistance for therapeutic gain. Over time, metabolic reprogramming has been recognised as
Externí odkaz:
https://doaj.org/article/d51e7468dbf544708448d7d166add061
Autor:
Martijn R. Molenaar, Mohammed Shahraz, Jeany Delafiori, Andreas Eisenbarth, Måns Ekelöf, Luca Rappez, Theodore Alexandrov
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Imaging mass spectrometry (MS) is becoming increasingly applied for single-cell analyses. Multiple methods for imaging MS-based single-cell metabolomics were proposed, including our recent method SpaceM. An important step in imaging MS-based single-c
Externí odkaz:
https://doaj.org/article/50e60aa0d5a74a509e9d81234f7d2b81
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Aberrant metabolism contributes to tumor initiation, progression, metastasis, and drug resistance. Metabolic dysregulation has emerged as a hallmark of several hematologic malignancies. Decoding the molecular mechanism underlying metabolic rewiring i
Externí odkaz:
https://doaj.org/article/86edd7eebf8c444f9e7960763278551f
Publikováno v:
Frontiers in Chemistry, Vol 9 (2022)
Compared with conventional optical microscopy techniques, mass spectrometry imaging (MSI) or imaging mass spectrometry (IMS) is a powerful, label-free analytical technique, which can sensitively and simultaneously detect, quantify, and map hundreds o
Externí odkaz:
https://doaj.org/article/de159f53c15d482d93dc708b60139bc5
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Metabolic reprogramming is one of the hallmarks of malignant tumors, which provides energy and material basis for tumor rapid proliferation, immune escape, as well as extensive invasion and metastasis. Blocking the energy and material supply of tumor
Externí odkaz:
https://doaj.org/article/cc17eed8abb044e8889b81d4e02336ef
Akademický článek
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