Zobrazeno 1 - 10
of 141
pro vyhledávání: '"single-cell DNA sequencing"'
Publikováno v:
Algorithms for Molecular Biology, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract Copy number aberrations (CNAs) are ubiquitous in many types of cancer. Inferring CNAs from cancer genomic data could help shed light on the initiation, progression, and potential treatment of cancer. While such data have traditionally been a
Externí odkaz:
https://doaj.org/article/1fe16961b9f745d39de888c1985282b8
Autor:
Michael P. Schneider, Amy E. Cullen, Justina Pangonyte, Jason Skelton, Harvey Major, Elke Van Oudenhove, Maria J. Garcia, Blas Chaves Urbano, Anna M. Piskorz, James D. Brenton, Geoff Macintyre, Florian Markowetz
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-27 (2024)
Abstract Cancer cells often exhibit DNA copy number aberrations and can vary widely in their ploidy. Correct estimation of the ploidy of single-cell genomes is paramount for downstream analysis. Based only on single-cell DNA sequencing information, s
Externí odkaz:
https://doaj.org/article/9e368e2318e242c8953f09f4b2805e9d
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background Copy number alteration (CNA) is one of the major genomic variations that frequently occur in cancers, and accurate inference of CNAs is essential for unmasking intra-tumor heterogeneity (ITH) and tumor evolutionary history. Single
Externí odkaz:
https://doaj.org/article/12d12acf9dce4c609e1fa19c9c6a61c9
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract A tumor contains a diverse collection of somatic mutations that reflect its past evolutionary history and that range in scale from single nucleotide variants (SNVs) to large-scale copy-number aberrations (CNAs). However, no current single-ce
Externí odkaz:
https://doaj.org/article/5435dde5ac3e4bb780badd7e110b055f
Autor:
Waled Bahaj, Tariq Kewan, Carmelo Gurnari, Arda Durmaz, Ben Ponvilawan, Ishani Pandit, Yasuo Kubota, Olisaemeka D. Ogbue, Misam Zawit, Yazan Madanat, Taha Bat, Suresh K. Balasubramanian, Hussein Awada, Ramsha Ahmed, Minako Mori, Manja Meggendorfer, Torsten Haferlach, Valeria Visconte, Jaroslaw P. Maciejewski
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-12 (2023)
Abstract Background TP53 mutations (TP53 MT ) occur in diverse genomic configurations. Particularly, biallelic inactivation is associated with poor overall survival in cancer. Lesions affecting only one allele might not be directly leukemogenic, ques
Externí odkaz:
https://doaj.org/article/be24204f0e834aaeb1aa9535926fa7e7
Autor:
Enrica Borsi, Ilaria Vigliotta, Andrea Poletti, Gaia Mazzocchetti, Vincenza Solli, Luca Zazzeroni, Marina Martello, Silvia Armuzzi, Barbara Taurisano, Ajsi Kanapari, Ignazia Pistis, Elena Zamagni, Lucia Pantani, Serena Rocchi, Katia Mancuso, Paola Tacchetti, Ilaria Rizzello, Simonetta Rizzi, Elisa Dan, Barbara Sinigaglia, Michele Cavo, Carolina Terragna
Publikováno v:
Cells, Vol 13, Iss 8, p 657 (2024)
Clonal hematopoiesis of indeterminate potential (CHIP) refers to the phenomenon where a hematopoietic stem cell acquires fitness-increasing mutation(s), resulting in its clonal expansion. CHIP is frequently observed in multiple myeloma (MM) patients,
Externí odkaz:
https://doaj.org/article/9eb6935ac05845519040d5dd9482e687
Autor:
Senbai Kang, Nico Borgsmüller, Monica Valecha, Jack Kuipers, Joao M. Alves, Sonia Prado-López, Débora Chantada, Niko Beerenwinkel, David Posada, Ewa Szczurek
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-33 (2022)
Abstract We present SIEVE, a statistical method for the joint inference of somatic variants and cell phylogeny under the finite-sites assumption from single-cell DNA sequencing. SIEVE leverages raw read counts for all nucleotides and corrects the acq
Externí odkaz:
https://doaj.org/article/effa6828cc9d44b49baa18e46c9ce1f7
Autor:
María García-Álvarez, Ana Yeguas, Cristina Jiménez, Alejandro Medina-Herrera, Verónica González-Calle, Montserrat Hernández-Ruano, Rebeca Maldonado, Irene Aires, Cristina Casquero, Inmaculada Sánchez-Villares, Ana Balanzategui, María Eugenia Sarasquete, Miguel Alcoceba, María Belén Vidriales, Marcos González-Díaz, Ramón García-Sanz, María Carmen Chillón
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 66 (2023)
Single-cell DNA sequencing can address the sequence of somatic genetic events during myeloid transformation in relapsed acute myeloid leukemia (AML). We present an NPM1-mutated AML patient with an initial low ratio of FLT3-ITD (low-risk ELN-2017), tr
Externí odkaz:
https://doaj.org/article/c7362ffa7647486f8f5d47e173974eb5
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