Zobrazeno 1 - 10
of 317
pro vyhledávání: '"single nuclei"'
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-15 (2024)
Abstract Chronic methamphetamine (METH) use, a prevalent psychostimulant, is known to impair attention, yet the cellular mechanisms driving these deficits remain poorly understood. Here, we employed a rat model of repeated passive METH injections and
Externí odkaz:
https://doaj.org/article/b3edd3bde2e5486ab1a73ce9b083ff85
Autor:
Deanne Nixie R. Miao, MacKenzie A. P. Wilke, John Pham, Feryal Ladha, Mansumeet Singh, Janilyn Arsenio, Emilia Luca, Alain Dabdoub, Wejian Yang, Jun J. Yang, Britt I. Drögemöller
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-9 (2024)
Abstract Background Cisplatin-induced ototoxicity (CIO), characterized by irreversible and progressive bilateral hearing loss, is a prevalent adverse effect of cisplatin chemotherapy. Alongside clinical risk factors, genetic variants contribute to CI
Externí odkaz:
https://doaj.org/article/667b8ba4552f40ea9190cfb73b71c7f6
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental contaminant that disrupts hepatic function leading to steatotic liver disease (SLD)-like pathologies, such as steatosis, steatohepatitis, and fibrosis. These effects ar
Externí odkaz:
https://doaj.org/article/fb48d6e31421443c87289a33eda499ff
Autor:
Yixuan Sheng, Yin-Ying Wang, Yuan Chang, Dongting Ye, Liying Wu, Hongen Kang, Xiong Zhang, Xiao Chen, Bin Li, Daliang Zhu, Ningning Zhang, Haisen Zhao, Aijun Chen, Haisheng Chen, Peilin Jia, Jiangping Song
Publikováno v:
Journal of Advanced Research, Vol 61, Iss , Pp 101-117 (2024)
Introduction: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, and it significantly increases the risk of cardiovascular complications and morbidity, even with appropriate treatment. Tissue remodeling has been a significant topic, w
Externí odkaz:
https://doaj.org/article/e9741c3688da42809bb1f488267983d8
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder featured by abnormal movements, arising from the extensive neuronal loss and glial dysfunction in the striatum. Although the causes and pathogenetic mechanisms
Externí odkaz:
https://doaj.org/article/487b16e576f540f6bd667122092c6b6f
Autor:
Cameron Church, Christian X. Fay, Emil Kriukov, Hui Liu, Ashley Cannon, Lauren Ashley Baldwin, David K. Crossman, Bruce Korf, Margaret R. Wallace, Andrea M. Gross, Brigitte C. Widemann, Robert A. Kesterson, Petr Baranov, Deeann Wallis
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Neurofibromatosis Type 1 (NF1) is caused by loss of function variants in the NF1 gene. Most patients with NF1 develop skin lesions called cutaneous neurofibromas (cNFs). Currently the only approved therapeutic for NF1 is selumetinib, a mitog
Externí odkaz:
https://doaj.org/article/d00a5353dd604d0dbaf40783a4391f24
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Myocardial infarction (MI) is the leading cause of premature death. The death of cardiomyocytes (CMs) and the dysfunction of the remaining viable CMs are the main pathological factors contributing to heart failure (HF) following MI. This stu
Externí odkaz:
https://doaj.org/article/b0cddc7eec4e4234b03f11f4c784b9f0
Publikováno v:
Japanese Dental Science Review, Vol 59, Iss , Pp 412-420 (2023)
Single-cell omics and multi-omics have revolutionized our understanding of molecular and cellular biological processes at a single-cell level. In bone biology, the combination of single-cell RNA-sequencing analyses and in vivo lineage-tracing approac
Externí odkaz:
https://doaj.org/article/ae3f77331f7b4de9a348fac25350d6da
Autor:
Susan Simorgh, Seyed Ahmad Mousavi, San Kit To, Vincent Pasque, Keimpe Wierda, Tim Vervliet, Meghdad Yeganeh, Paria Pooyan, Yoke Chin Chai, Catherine Verfaillie, Hossein Baharvand
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 22, Pp 1055-1076 (2023)
Human cerebral organoids (COs) are self-organizing three-dimensional (3D) neural structures that provide a human-specific platform to study the cellular and molecular processes that underlie different neurological events. The first step of CO generat
Externí odkaz:
https://doaj.org/article/6912e5eb3a054960b29aa13708ffd2f2
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